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NECA

NECA Structure
NECA structure
CAS No.
35920-39-9
Chemical Name:
NECA
Synonyms
NECA;D-NECA;744-96;765-21;B-744-96;NECA USP/EP/BP;5'-ETHYLCARBOXAMIDOADENOSINE;5’-EthylcarboxamidoAdenosine;Adenosine-5'-ethylcarboxamide;5'-N-Ethylcarboxamideadenosine
CBNumber:
CB0763077
Molecular Formula:
C12H16N6O4
Molecular Weight:
308.29
MDL Number:
MFCD00069195
MOL File:
35920-39-9.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
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NECA Properties

Melting point 229-231°C
Density 1.87±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL Solutions may be stored for several days at 4°C.
pka 12.93±0.70(Predicted)
form powder
color white
Stability Hygroscopic
InChIKey JADDQZYHOWSFJD-FLNNQWSLSA-N
CAS DataBase Reference 35920-39-9

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H300
Precautionary statements  P264-P270-P301+P310-P405-P501
Hazard Codes  T+
Risk Statements  28
Safety Statements  22-26-36-45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  VJ2232000
HazardClass  6.1(a)
PackingGroup  I
HS Code  29349990

NECA price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich E2387 5′-(N-Ethylcarboxamido)adenosine powder 35920-39-9 50mg $223 2024-03-01 Buy
Sigma-Aldrich 119140 Adenosine Receptor Agonist, NECA 35920-39-9 10mg $69 2024-03-01 Buy
Alfa Aesar J60405 5'-N-Ethylcarboxamidoadenosine 35920-39-9 10mg $83 2021-12-16 Buy
Alfa Aesar J60405 5'-N-Ethylcarboxamidoadenosine 35920-39-9 50mg $351 2021-12-16 Buy
Cayman Chemical 21420 5'-N-Ethylcarboxamidoadenosine ≥99% 35920-39-9 5mg $25 2021-12-16 Buy
Product number Packaging Price Buy
E2387 50mg $223 Buy
119140 10mg $69 Buy
J60405 10mg $83 Buy
J60405 50mg $351 Buy
21420 5mg $25 Buy

NECA Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

5′-(N-Ethylcarboxamido)adenosine has been used:

  • for the purification of human adenosine A2Areceptor (A2AR) in decylmaltoside (DM)
  • to determine nonspecific binding of adenosine receptors
  • to investigate adenosine 2B receptor (RA2B) mechanism of action by competition assay

Uses

Potent adenosine receptor agonist with some affinity at A1 and A2 receptors

Uses

A potent adenosine receptor agonist. Inhibits platelet aggregation and is centrally active in vivo

Definition

ChEBI: A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by an N-ethylcarboxamido group.

General Description

A cell-permeable adenosine analog that acts a potent non-selective agonist of adenosine receptors (Ki = 14 nM, 20 nM, 2.4 μM and 6.2 nM for A1, A2A, A2B, A3, respectively). Increases intracellular cAMP production (EC50 = 3.1 μM in A2B expressing CHO cells). Shown to increase glucagon release in a dose-dependent manner and inhibit insulin release at low concentrations. Although at higher concentration some insulin release is observed. Also, displays a wide range adenosine-dependent effects, such as blocking platelet aggregation and inhibiting DNA synthesis. When administered at reperfusion, it is shown reduce infarction and block the formation of the mitochondrial permeability transition pore by activating p70S6 kinase.

Biological Activity

Potent adenosine receptor agonist (K i values are 14, 20 and 6.2 nM for human A 1 , A 2A and A 3 receptors respectively; EC 50 = 2.4 μ M for human A 2B ). Inhibits platelet aggregation and is centrally active in vivo .

Biochem/physiol Actions

Reversible: yes

storage

Store at +4°C

NECA Preparation Products And Raw materials

Raw materials

Preparation Products

NECA Suppliers

Global( 101)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22968 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
TopScience Biochemical 		00852-68527855 info@itopbiochem.com China Hong Kong 902 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 28200 58
NewCan Biotech Limited 		+86-0571-86912261 +8613735419629 sales@newcanbio.com China 9976 58
Nanjing Doge Biomedical Technology Co., Ltd 		+86-25-58227606 +86-15305155328 sales@dogechemical.com China 4128 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43348 58
Supplier Advantage
career henan chemical co 		58
Hubei xin bonus chemical co. LTD 		58
BOC Sciences 		58
TopScience Biochemical 		58
Dideu Industries Group Limited 		58
NewCan Biotech Limited 		58
Nanjing Doge Biomedical Technology Co., Ltd 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
LEAPCHEM CO., LTD. 		58

View Lastest Price from NECA manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
NECA pictures 2019-09-02 NECA
35920-39-9
 US $7.00 / KG 1KG 99% JD 562 Career Henan Chemical Co
  • NECA pictures
  • NECA
    35920-39-9
  • US $7.00 / KG
  • 99%
  • Career Henan Chemical Co

NECA Spectrum

NECA(35920-39-9)1HNMR

35920-39-9(NECA)Related Search:

he-neca 2-IODO-NECA 5'-EthylcarboxaMido-2',3'-isopropylidene Adenosine 2-Chloro-NECA NECA 5'-N-[ADENINE-2,8-3H]-
N6-BENZYL-NECA CGS 21680, [CARBOXYETHYL-3H(N)]- 2-CHLORO-2',3'-O-ISOPROPYLIDENEADENOSINE-5'-N-ETHYLCARBOXAMIDE EB-47 DIHYDROCHLORIDE DIHYDRATE CGS 21680
NECA 5'-(N-CYCLOPROPYL)CARBOXAMIDOADENOSINE DANSYL-NECA 5'-N-ETHYLCARBOXAMIDOADENOSINE, [ADENINE-2,8-3H]- CGS-21680 HYDROCHLORIDE

1of3

5'-N6-Ethylcarboxamidoadenosine 5'-ETHYLCARBOXAMIDOADENOSINE 1-(6-AMINO-9H-PURIN-9-YL)-1-DEOXY-N-ETHYL-BETA-D-RIBOFURANURONAMIDE 1-(6-amino-9h-purin-9-yl)-1-deoxy-n-ethylribofuranuronamidehemihydrate 1-(6-amino-9h-purin-9-yl)-1-deoxy-n-ethyl-ribofuranuronamidhemihydrate 5’-n(sup6)-ethylcarboxamidoadenosinehemihydrate 5’-n-ethylcarboxamidoadenosinehemihydrate adenosine-5’-(n-ethyl)carboxamidehemihydrate adenosine-5’-(n-ethylcarboxamide NECA b-D-RibofuranuronaMide, 1-(6-aMino-9H-purin-9-yl)-1-deoxy-N-ethyl- D-NECA NECA,5′-(N-Ethylcarboxamido)adenosine Adenosine Receptor Agonist, NECA 5'-(N-ETHYLCARBOXAMIDO)-ADENOSINE 1-(6-Amino-(9H)-purin-9-yl)-1-deoxy-N-ethyl-b-D-ribofuranuronamide NECA, 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-D-ribofuranuronamide 5'-Ethylcarboxamido-D-adenosine 5'-N-Ethylcarboxamideadenosine 744-96 765-21 Adenosine-5'-ethylcarboxamide B-744-96 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide N-ethyl-5'-carboxamidoadenosine Adenosine Receptor Agonist, NECA - CAS 35920-39-9 - Calbiochem β-D-Ribofuranuronamide, 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl- NECA USP/EP/BP 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide 5’-EthylcarboxamidoAdenosine 35920-39-9 C12H16N6O4 Potent adenosine receptor agonist with nearly equal affinity at A1 and A2 receptors. Bases & Related Reagents Inhibitors Nucleotides Adenosine receptor