NU6102
- CAS No.
- 444722-95-6
- Chemical Name:
- NU6102
- Synonyms
- NU6102;CDK1/2 INHIBITOR II;O6-CYCLOHEXYLMETHYL-2-(4-SULFAMOYLANILINO)PURINE;6-CYCLOHEXYLMETHOXY-2-(4'-SULFAMOYLANILINO)PURINE;4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]benzenesulfonamide;Benzenesulfonamide, 4-[[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino]-
- CBNumber:
- CB0811835
- Molecular Formula:
- C18H22N6O3S
- Molecular Weight:
- 402.47
- MDL Number:
- MFCD08702693
- MOL File:
- Mol file
| Melting point | 152-154℃ (water ) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO:1.0(Max Conc. mg/mL);2.5(Max Conc. mM) |
| form | White to off-white solid. |
| color | White to off-white |
| FDA UNII | X5J53DR704 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H341 |
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 |
NU6102 price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 217713 | Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem | 444722-95-6 | 1mg | $172 | 2024-03-01 | Buy |
| Sigma-Aldrich | 217713 | Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem | 444722-95-6 | 5mg | $322 | 2023-01-07 | Buy |
| Cayman Chemical | 13317 | NU 6102 ≥95% | 444722-95-6 | 1mg | $54 | 2024-03-01 | Buy |
| Cayman Chemical | 13317 | NU 6102 ≥95% | 444722-95-6 | 5mg | $168 | 2024-03-01 | Buy |
| TRC | N925290 | NU6102 | 444722-95-6 | 50mg | $835 | 2021-12-16 | Buy |
NU6102 Chemical Properties,Uses,Production
Uses
Cyclin-dependent kinases (CDKs) play a key role in regulating cell division by phosphorylating distinct substrates in different phases of the cell cycle. Cell cycle deregulation in many cancers often results from altered CDK activity. Thus, CDKs are potential pharmacological targets for anticancer agents. NU 6102 is a potent inhibitor of Cdk1 and Cdk2 with Ki values of 9 and 6 nM and IC50 values of 9.5 and 5.4 nM, respectively. NU 6102 inhibits Cdk4 activity with an IC50 value of 1.6 μM, suggesting it is most selective for Cdk2. Time-lapse videomicroscopy reveals that 20 μM NU 6102 delays cell entry into mitosis where most cells appear to eventually complete mitotic division but cannot correctly undergo cytokinesis, and hence become binucleated with an abnormal number of centrosomes. In SKUT-1B cancer cells a 24 h exposure to NU 6102 induced G2 arrest, inhibition of target protein phosphorylation, and cytotoxicity with an LC50 value of 2.6 μM.
Uses
NU6102 is a known potent inhibitor of CDK1, CDK2 and CDK7. Cyclin-dependent kinases play a key role in the regulation of cell division which is controlled by the phosphorylation of distinct substrates in different phases of the cell cycle. In any circumstance where the cell cycle is deregulated, cyclin-dependent kinases activities are altered. Since NU6102 is known to exert inhibitory activities against CDKs, it has potential to act as a control in the cell cycle, especially in various cancers. NU6102 is known to be an anticancer agent use to repress the expression of breast cancer cells.
storage
+4°C
NU6102 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3989 | 66 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Changyan Chem & Tech Co., Ltd. | 021-021-20242659 18930833303 | order@changyanchem.com | China | 5008 | 55 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55827 | 58 |