metopimazine
- CAS No.
- 14008-44-7
- Chemical Name:
- metopimazine
- Synonyms
- NG101;NG 101;NG-101;RP-9965;EXP 999;9965 RP;Nortrip;Vogalene;metopimazine;metopimazine USP/EP/BP
- CBNumber:
- CB0934482
- Molecular Formula:
- C22H27N3O3S2
- Molecular Weight:
- 445.59808
- MDL Number:
- MFCD00837528
- MOL File:
- 14008-44-7.mol
- MSDS File:
- SDS
| Melting point | 170.5℃ |
|---|---|
| Boiling point | 721.2±60.0 °C(Predicted) |
| Density | 1.1920 (rough estimate) |
| refractive index | 1.6320 (estimate) |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 16.44±0.20(Predicted) |
| color | Pale Yellow |
| CAS DataBase Reference | 14008-44-7 |
| FDA UNII | 238S75V9AV |
| ATC code | A04AD05 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| Toxicity | LD50 in male rats (mg/kg): 976 orally, 1080 s.c. (Goldenthal) |
metopimazine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M338760 | Metopimazine | 14008-44-7 | 50mg | $1695 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008052 | METOPIMAZINE 95.00% | 14008-44-7 | 50MG | $1871.1 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008052 | METOPIMAZINE 95.00% | 14008-44-7 | 5MG | $385 | 2021-12-16 | Buy |
metopimazine Chemical Properties,Uses,Production
Chemical Properties
Pale Yellow Solid
Originator
Nortrip,Rhodia
Uses
metopimazine is used to prevent emesis during chemotherapies.
Uses
Metopimazine (MPZ) is used to prevent emesis during chemotherapies. Antiemetic.
Definition
ChEBI: Metopimazine is a member of phenothiazines.
Manufacturing Process
2-Methylsulfonyl-10-(3-chloropropyl)phenothiazine was prepared by
condensation of 1-bromo-3-chloropropane and 2-methylsulfonyl phenothiazine
in liquid ammonia in presence of obtained in situ sodium amide.
10 g 2-methylsulfonyl-10-(3-chloropropyl)-phenothiazine, 4 g piperidine-4-
carboxylic acid amide, 3.5 g dry sodium carbonate in 200 ml of ethanol was
heated to reflux for 24 hours. Than 1.75 g sodium carbonate was added and
the mixture was heated another 8 hours. After that the new 1.75 g portion of
sodium carbonate was added and heated for 16 hours. The solvent was
removed in vacuum (20 mm Hg). The residue was stirred with 50 ml water
and 150 ml ethyl acetate. The organic layer was separated and extracted with
200 ml 1 N hydrochloric acid. The water layer was made alkaline with 4 N
sodium hydroxide, extracted with ethyl acetate and dried over sodium sulfate.
The solvent was removed in vacuum (20 mm Hg) to dryness. The obtained
residue 2-methylsulfonyl-10-(3-(4-carbamoylpiperidino)propyl)phenothiazine
was recrystallized from ethyl acetate. Yield 6 g; MP: 170°-171°C.
Therapeutic Function
Antiemetic
metopimazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9126 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; | info@afinechem.com | China | 15377 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9635 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50000 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |