Dihydrodaidzein
- CAS No.
- 17238-05-0
- Chemical Name:
- Dihydrodaidzein
- Synonyms
- Dihydrodaidzein>DIHYDRODAIDZEIN hplc;Dihydrodaidzein standard;7-hydroxy-3-(4-hydroxyphenyl)chroman-4-one;7-Hydroxy-3-(4-hydroxyphenyl)-4-chromanone;7-hydroxy-3-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one;inhibit,Endogenous Metabolite,Dihydrodaidzein,Inhibitor;2,3-Dihydro-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-3-(4-hydroxyphenyl)-;2,3-Dihydro-7-hydroxy-3-(4-hydroxyphenyl)-4H-1- benzopyran-4-one,99%e.e.
- CBNumber:
- CB11176286
- Molecular Formula:
- C15H12O4
- Molecular Weight:
- 256.25
- MDL Number:
- MFCD00210494
- MOL File:
- 17238-05-0.mol
- MSDS File:
- SDS
| Melting point | 250-251°C |
|---|---|
| Boiling point | 529.5±50.0 °C(Predicted) |
| Density | 1.386±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under Inert Atmosphere |
| solubility | ≤0.1mg/ml in ethanol;30mg/ml in DMSO;10mg/ml in dimethyl formamide |
| pka | 7.71±0.40(Predicted) |
| form | powder to crystal |
| color | Light orange to Yellow to Green |
| λmax | 313nm(EtOH aq.)(lit.) |
| CAS DataBase Reference | 17238-05-0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| HS Code | 2932990090 | |||||||||
| NFPA 704 |
|
Dihydrodaidzein price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SMB00944 | Dihydrodaidzein ≥95% | 17238-05-0 | 10MG | $176 | 2024-03-01 | Buy |
| Sigma-Aldrich | SMB00944 | Dihydrodaidzein ≥95% | 17238-05-0 | 50MG | $410 | 2024-03-01 | Buy |
| TCI Chemical | D4239 | Dihydrodaidzein >93.0%(HPLC) | 17238-05-0 | 25mg | $313 | 2024-03-01 | Buy |
| Cayman Chemical | 17423 | Dihydrodaidzein ≥98% | 17238-05-0 | 5mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 17423 | Dihydrodaidzein ≥98% | 17238-05-0 | 10mg | $70 | 2024-03-01 | Buy |
Dihydrodaidzein Chemical Properties,Uses,Production
Chemical Properties
Light Beige Needles
Uses
Daidzein is an isoflavonoid phytoestrogenic compound found in soybeans, pea pods, clover, kudzu, and other legumes. Dihydrodaidzein is an active, estrogenic metabolite of daidzein. It has vasodilatory action on rat isolated aortic rings at 1 μg/ml. It stimulates the estrogen receptor-dependent growth of breast cancer MCF-7 cells at micromolar concentrations. Dihydrodaidzein is produced by the metabolism of daidzein in colonic bacteria and may be further metabolized to various bioactive compounds, including equol .
Uses
A metabolite of Daidzein.
Definition
ChEBI: A hydroxyisoflavanone that is isoflavanone carrying two hydroxy substituents located at positions 4' and 7.
Biological Activity
dihydrodaidzein, an active, estrogenic metabolite of daidzein in colonic bacteria, probably is further metabolized to various bioactive compounds including equol. as an estrogen receptor agonist, dihydrodaidzein, at micromolar concentrations, activates the estrogen receptor-dependent growth of breast cancer cells. daidzein, an isoflavonoid phytoestrogenic compound, is found in soybeans, clover, kudzu, and other legumes.
in vitro
prostatic fluid and plasma concentrations of dihydrodaidzein were sufficient to block the growth of benign human prostatic epithelial cells (prec). dihydrodaidzein showed a significant inhibitory effect on the growth of prostate cancer cell line lncap. additionally, dihydrodaidzein slightly triggered the apoptosis of prec. in addition to affecting apoptosis, dihydrodaidzein decreased proliferation, which was associated with the changes in cell cycle distribution and caspase 3 activation [1].
in vivo
male c57b1/6 wild type mice were administered orally with dihydrodaidzein at a dose of 25 mg/kg/day for 4 weeks. compared to the control groups, the neointima of mice treated with dihydrodaidzein was thickened. in dihydrodaidzein-treated mice, the intimal thickness in the non-injured right iliac artery was not altered. moreover, neointimal proliferation was selectively blocked by dihydrodaidzein via suppressing the migration and proliferation of vascular smooth muscle cell and dampening the endothelial apoptosis [2].
References
[1]. hedlund, t., bokhoven, a., johannes, w., nordeen, s., & ogden, l. prostatic fluid concentrations of isoflavonoids in soy consumers are sufficient to inhibit growth of benign and malignant prostatic epithelial cells in vitro. the prostate. 2006; 66(5): 557-566.
[2]. shen, j., white, m., husband, a., hambly, b., & bao, s. phytoestrogen derivatives differentially inhibit arterial neointimal proliferation in a mouse model. european journal of pharmacology. 2006; 548(1-3): 123-128.
Dihydrodaidzein Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Aktin Chemicals, Inc. | 028-85159085 | info@aktinchem.com | CHINA | 1025 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35453 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50000 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
View Lastest Price from Dihydrodaidzein manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-24 | Dihydrodaidzein
17238-05-0
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
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- Dihydrodaidzein
17238-05-0
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
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