DIBENZAZEPINE
- CAS No.
- 209984-56-5
- Chemical Name:
- DIBENZAZEPINE
- Synonyms
- GSI-XX;CS-366;YO01027;DIBENZAZEPINE;Deshydroxy LY-411575;6-Chloro-α-Tetralone;γ-Secretase Inhibitor XX;YO-01027 (Dibenzazepine);Dibenzazepine (YO-01027);γ-Secretase Inhibitor XX
- CBNumber:
- CB11234300
- Molecular Formula:
- C26H23F2N3O3
- Molecular Weight:
- 463.48
- MDL Number:
- MFCD12828734
- MOL File:
- 209984-56-5.mol
- MSDS File:
- SDS
| Melting point | 257-259?C |
|---|---|
| Boiling point | 801.3±65.0 °C(Predicted) |
| Density | 1.35 |
| storage temp. | -20°C |
| solubility | DMSO: soluble15mg/mL, clear |
| pka | 12.76±0.20(Predicted) |
| form | White solid |
| color | white to beige |
| InChIKey | QSHGISMANBKLQL-OWJWWREXSA-N |
| FDA UNII | J411KQJ8C2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29337900 | |||||||||
| NFPA 704 |
|
DIBENZAZEPINE price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 565789 | γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem This γ-secretase inhibitor, CAS 209984-56-5, is a cell-permeable dibenzazepine compound that lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model. | 209984-56-5 | 500μg | $417 | 2024-03-01 | Buy |
| Sigma-Aldrich | 565789 | γ-Secretase Inhibitor XX | 209984-56-5 | 1mg | $532 | 2024-03-01 | Buy |
| Alfa Aesar | J64904 | gamma-Secretase Inhibitor XX | 209984-56-5 | 3mg | $761 | 2023-06-20 | Buy |
| Cayman Chemical | 14627 | DBZ ≥98% | 209984-56-5 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 14627 | DBZ ≥98% | 209984-56-5 | 5mg | $63 | 2024-03-01 | Buy |
DIBENZAZEPINE Chemical Properties,Uses,Production
Description
γ-
Chemical Properties
White Solid
Uses
γ-Secretase is a multi-subunit aspartyl protease that cleaves amyloid precursor protein (APP) and many other type 1 transmembrane proteins, including Notch, E-cadherin, and ErbB4. The proteolysis of APP by secretases produces beta amyloid (Aβ), a 39- to 42-amino acid peptide which forms the amyloid plaques that are characteristic of Alzheimer’s disease. DBZ is a dipeptidic inhibitor of γ-secretase that potently blocks the cleavage of Notch into its active signaling effector, Notch intracellular domain, in human T cell lymphoma (SupT1) cells (IC50 = 1.7 nM). Within 4 hours after a single 100 μM/kg dose, DBZ demonstrates anti-Alzheimer activity in an APP transgenic mouse model characterized by high levels of Aβ40 by reducing Aβ40 levels by 71%.
Uses
DIBENZAZEPINE is a dipeptidic-secretase inhibitor and a antiAlzheimer agent.
Uses
A dipeptidic γ-secretase inhibitor. AntiAlzheimer agent.
General Description
A cell-permeable, potent γ-secretase inhibitor that significantly lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 μmol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC50 = 1.7 nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and ApcMin mouse models (10 μmol/kg, i.p).
Biochem/physiol Actions
Cell permeable: yes
target
APPL
storage
-20°C
DIBENZAZEPINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
View Lastest Price from DIBENZAZEPINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-03-06 | DIBENZAZEPINE
209984-56-5
|
US $1.00 / KG | 1KG | 97%-99.9% | 200kg | Career Henan Chemical Co |
-
- DIBENZAZEPINE
209984-56-5
- US $1.00 / KG
- 97%-99.9%
- Career Henan Chemical Co