ChemicalBook >> CAS DataBase List >>macbecin I
macbecin I
- CAS No.
- 73341-72-7
- Chemical Name:
- macbecin I
- Synonyms
- Macbecin;macbecin I;(15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin;(6S,15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methylgeldanamycin;Geldanamycin, 6,17-didemethoxy-15-methoxy-6-methyl-11-O-methyl-, (15R)-
- CBNumber:
- CB11346962
- Molecular Formula:
- C30H42N2O8
- Molecular Weight:
- 558.67
- MDL Number:
- MOL File:
- 73341-72-7.mol
Last updated:2023-05-18 11:30:59
| Melting point | 205-206 °C(Solv: ethanol (64-17-5); water (7732-18-5)) |
|---|---|
| Boiling point | 736.2±60.0 °C(Predicted) |
| Density | 1.17±0.1 g/cm3(Predicted) |
| storage temp. | Desiccate at -20°C |
| solubility | Soluble in DMSO > 10 mM |
| form | Powder |
| pka | 8.62±0.70(Predicted) |
| EWG's Food Scores | 1 |
| FDA UNII | GB3Z258LF8 |
macbecin I price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22225 | Macbecin I ≥95% | 73341-72-7 | 1mg | $291 | 2024-03-01 | Buy |
| Tocris | 3061 | MacbecinI | 73341-72-7 | 1 | $311 | 2021-12-16 | Buy |
| Usbiological | 255749 | Macbecin I | 73341-72-7 | 1mg | $573 | 2021-12-16 | Buy |
| TRC | M107525 | MacbecinI | 73341-72-7 | 0.5mg | $1200 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008044 | MACBECIN I 95.00% | 73341-72-7 | 2.5G | $1473.14 | 2021-12-16 | Buy |
macbecin I Chemical Properties,Uses,Production
Uses
Macbecin I is an ansamycin antibiotic inhibitor of Hsp90 activity.
Biological Activity
Ansamycin antibiotic compound that inhibits Hsp90 activity (IC 50 = 2 μ M) by binding to the ATP-binding site. Exhibits antitumor and cytocidal activities (IC 50 ~ 0.4 μ M) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. Displays higher affinity and potency than geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ).
macbecin I Preparation Products And Raw materials
Raw materials
Preparation Products
macbecin I Suppliers
Global( 23)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |
73341-72-7(macbecin I)Related Search:
macbecin I
(6S,15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methylgeldanamycin
(15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin
Geldanamycin, 6,17-didemethoxy-15-methoxy-6-methyl-11-O-methyl-, (15R)-
Macbecin
73341-72-7