Amsacrine
- CAS No.
- 51264-14-3
- Chemical Name:
- Amsacrine
- Synonyms
- AMSA;CI-880;m-AMSA;C01553;Amekrin;Amsidyl;Amsakrin;AMSIDINE;Lamasine;SN 11841
- CBNumber:
- CB1236394
- Molecular Formula:
- C21H19N3O3S
- Molecular Weight:
- 393.46
- MDL Number:
- MFCD00242748
- MOL File:
- 51264-14-3.mol
| Melting point | 230-240 °C |
|---|---|
| Boiling point | 563.0±60.0 °C(Predicted) |
| Density | 1.2205 (rough estimate) |
| refractive index | 1.6740 (estimate) |
| storage temp. | 2-8°C(protect from light) |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 8.55±0.10(Predicted) |
| CAS DataBase Reference | 51264-14-3 |
| NCI Dictionary of Cancer Terms | amsacrine |
| FDA UNII | 00DPD30SOY |
| IARC | 2B (Vol. 76) 2000 |
| NCI Drug Dictionary | amsacrine |
| ATC code | L01XX01 |
| Proposition 65 List | Amsacrine |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H227 |
| Precautionary statements | P501-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235 |
| RIDADR | 3249 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 in male, female CDF1 mice: 810 mg/m2; 729 mg/m2 orally (Pavkov) |
Amsacrine price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A898095 | Amsacrine | 51264-14-3 | 50mg | $140 | 2021-12-16 | Buy |
| ApexBio Technology | B1302 | Amsacrine | 51264-14-3 | 100mg | $245 | 2021-12-16 | Buy |
| AK Scientific | C529 | Amsacrine | 51264-14-3 | 100mg | $261 | 2021-12-16 | Buy |
| ApexBio Technology | B1302 | Amsacrine | 51264-14-3 | 25mg | $156 | 2021-12-16 | Buy |
| ApexBio Technology | B1302 | Amsacrine | 51264-14-3 | 50mg | $179 | 2021-12-16 | Buy |
Amsacrine Chemical Properties,Uses,Production
Description
Amsacrine is a cytostatic reported to be active against adult lymphoblastic leukemia which has failed primary treatment or become resistant. Its clinical use, however, is associated with significant neuro-, gastro- and hepatotoxicity.
Originator
Auckland Cancer Chemotherapy Lab (New Zealand)
Uses
Amsacrine (Amsidyl) is used as an Investigational drug.
Uses
Antineoplastic.
Uses
Amsacrine is a drug undergoing intensive trials for severe leukemia and lymphoma. It is a cytotoxic drug that binds with DNA with expressed specificity to the adenosine–tyrosine pair, thus inhibiting DNA synthesis. It has been suggested to be used for severe leukemia. A synonym of this drug is amsidyl.
Definition
ChEBI: A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
brand name
Amsidyl (Parke-Davis);Amsakrin.
Synthesis
Amsacrine, 4-(9-acridinylamino)-3-methoxyphenyl-N-methansulfonamide (30.6.11), is made by sulfonating 4-nitro-m-anisidine with methanesulfonyl chloride, which forms a sulfonyl amide 30.6.9, and the nitro group is reduced to an amino group by hydrogen, forming 4-amino-3-methoxyphenyl-N-methansulfonamide (30.6.10). Reacting this with 9-chloroacridine gives amsacrine (30.6.11).
References
[1] nelson em, tewey km, liu lf. mechanism of antitumor drug action: poisoning of mammalian dna topoisomerase ii on dna by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. proc natl acad sci u s a. 1984 mar;81(5):1361-5.
Amsacrine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 2263 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28506 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; | info@afinechem.com | China | 15377 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20356 | 58 |
View Lastest Price from Amsacrine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-02 | Amsacrine USP/EP/BP
51264-14-3
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-04-30 | Amsacrine
51264-14-3
|
US $0.00-0.00 / Kg | 1KG | 99.0%+ | 800 tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-01-10 | Amsacrine
51264-14-3
|
US $9.80 / KG | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
-
- Amsacrine USP/EP/BP
51264-14-3
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Amsacrine
51264-14-3
- US $0.00-0.00 / Kg
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd
-
- Amsacrine
51264-14-3
- US $9.80 / KG
- ≥98%
- Career Henan Chemical Co