VAMICAMIDE
- CAS No.
- 132373-81-0
- Chemical Name:
- VAMICAMIDE
- Synonyms
- 2-Pyridineacetamide, α-[(2R)-2-(dimethylamino)propyl]-α-phenyl-, (αR)-rel-
- CBNumber:
- CB12446496
- Molecular Formula:
- C18H23N3O
- Molecular Weight:
- 297.39
- MDL Number:
- MFCD00909139
- MOL File:
- 132373-81-0.mol
| Melting point | 156-157° |
|---|---|
| FDA UNII | RU10K34QRU |
VAMICAMIDE Chemical Properties,Uses,Production
Originator
Vamicamide,Fujisawa Pharmaceutical
Uses
Antiepileptic; anticonvulsant.
Manufacturing Process
Conc. sulfuric acid (11 ml) was added to 4-(N,N-dimethylamino)-2-phenyl-2- (2-pyridyl)-valeronitrile (6.3 g) at 0°C. Then water (1 ml) was added thereto. After being heated at 90°C for 3 hours, the mixture was poured into ice-water, adjusted to pH 10 with 10% aqueous sodium hydroxide and extracted with ethyl acetate (3x50ml). The extracts were combined, and washed with water, dried over magnesium sulfate and evaporated under reduced pressure. The obtained crude crystal was recrystallized from diethyl ether to give 4-(N,N_x0002_dimethylamino)-2-phenyl-2-(2-pyridyl)-valeramide (1.89 g). MP: 132-134°C. Recrystallization from 40% water ethanol gave MP: 156-157°C. The structure of the product was confirmed by UR, NMR (CDCl3) spectra and elemental analysis.
Therapeutic Function
Anticholinergic, Spasmolytic
VAMICAMIDE Preparation Products And Raw materials
VAMICAMIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20035 | 58 |
| Supplier | Advantage |
|---|---|
| Suzhou Meishi Biotechnology Co., Ltd. | 58 |