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TIC10

TIC10 Structure
TIC10 structure
CAS No.
1616632-77-9
Chemical Name:
TIC10
Synonyms
imipridone;TIC10;ONC201;CS-2579;ONC201,TIC10;dordaviprone;TIC-10 (ON201);TIC10(ONC-201);TIC 10 active isomer;TIC10 (imipridone, ONC201, NSC350625)
CBNumber:
CB12711459
Molecular Formula:
C24H26N4O
Molecular Weight:
386.49
MDL Number:
MFCD28118993
MOL File:
1616632-77-9.mol
Last updated:2023-05-18 11:31:07
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TIC10 Properties

Boiling point 559.7±60.0 °C(Predicted)
Density 1.24±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Soluble in DMSO (up to 25 mg/ml with warming).
pka 6.38±0.20(Predicted)
form solid
color Pale yellow
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
FDA UNII 9U35A31JAI

TIC10 price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16109 TIC10 ≥98% 1616632-77-9 1mg $32 2024-03-01 Buy
Cayman Chemical 16109 TIC10 ≥98% 1616632-77-9 5mg $109 2024-03-01 Buy
Cayman Chemical 16109 TIC10 ≥98% 1616632-77-9 10mg $199 2024-03-01 Buy
Cayman Chemical 16109 TIC10 ≥98% 1616632-77-9 25mg $420 2024-03-01 Buy
TRC B285480 7-Benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one 1616632-77-9 50mg $160 2021-12-16 Buy
Product number Packaging Price Buy
16109 1mg $32 Buy
16109 5mg $109 Buy
16109 10mg $199 Buy
16109 25mg $420 Buy
B285480 50mg $160 Buy

TIC10 Chemical Properties,Uses,Production

Description

TIC10 induces the expression of TNF-related apoptosis-inducing ligand (TRAIL) at 1-5 μM in a p53-independent manner. It is orally active, stable, and crosses the blood-brain barrier. The induction of TRAIL results from dual inhibition of Akt and ERK1/2 combined with nuclear translocation of the transcription factor FOXO3a. TIC10 suppresses the growth of orthotopic human glioblastoma multiforme tumors in mice.

Uses

7-Benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one is used in biological studies for structure confirmation and pharmacophore reassignment for induction of immunosurveillance cytokine TRAIL in macrophages. The structure of this compound was misassigned for many years as H291055. The resolution of this issue was recently highlighted in Chemical and Engeneering News 92(23) 32 (2014).

References

1) Allen?et al.?(2013)?Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects, Sci. Transl. Med.?5?171ra17 2) Allen?et al.?(2015)?Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway,?Mol. Cancer.?14?99 3) Allen?et al.?(2016)?Discovery and Clinical Introduction of First-In-Class Imipridone ONC201, Oncotarget?7?74380 4) Ishizawa?et al.?(2019)?Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality, Cancer Cell?35?721

TIC10 Preparation Products And Raw materials

Raw materials

Preparation Products

TIC10 Suppliers

Global( 94)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
Accela ChemBio Inc. 		(+1)-858-699-3322 info@accelachem.com United States 19965 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23556 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24738 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Accela ChemBio Inc. 		58
BOC Sciences 		58
career henan chemical co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
ANHUI WITOP BIOTECH CO., LTD 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
LEAP CHEM CO., LTD. 		58
TargetMol Chemicals Inc. 		58

View Lastest Price from TIC10 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TIC10 pictures 2022-02-19 TIC10
1616632-77-9
 US $0.00 / gram 1gram 99% 10kg Zhejiang J&C Biological Technology Co.,Limited
4-[5-methyl-4-[(4-methylphenyl)sulfonylmethyl]-1,3-oxazol-2-yl]-N-(pyridin-3-ylmethyl)benzamide pictures 2020-01-02 4-[5-methyl-4-[(4-methylphenyl)sulfonylmethyl]-1,3-oxazol-2-yl]-N-(pyridin-3-ylmethyl)benzamide
1616632-77-9
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co
  • TIC10 pictures
  • TIC10
    1616632-77-9
  • US $0.00 / gram
  • 99%
  • Zhejiang J&C Biological Technology Co.,Limited

TIC10 Spectrum

TIC10(1616632-77-9)1HNMR

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ONC201,TIC10 TIC-10 (ON201) 2,4,6,7,8,9-Hexahydro-4-[(2-methylphenyl)methyl]-7-(phenylmethyl)imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one TIC10(ONC-201) TIC 10 active isomer ONC201 7-Benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-on TIC10 TIC10 (imipridone, ONC201, NSC350625) Imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, 2,4,6,7,8,9-hexahydro-4-[(2-methylphenyl)methyl]-7-(phenylmethyl)- CS-2579 (11-benzyl-7-[(2-methylphenyl)methyl]-2,5,7,11-tetraazatricyclo[7.4.0.02,6]trideca-1(9),5-dien-8-one) ONC201; ONC 201; ONC-201; NSC350625; NSC-350625; NSC 350625; TIC10; TIC 10; TIC-10; TRAIL INDUCING COMPOUND 10; IMIPRIDONE imipridone dordaviprone 1616632-77-9 APL APIS