INDIRUBIN-3'-MONOXIME
- CAS No.
- 160807-49-8
- Chemical Name:
- INDIRUBIN-3'-MONOXIME
- Synonyms
- -monoxime;Indirubin-3;INDIRUBIN-3'-OXIME;Indirubine-3'-oxime;Indirubin-3'-monoxime;INDIRUBIN-3'-MONOXIME;INDIRUBIN-3’-MONOOXIME;3-(Hydroxyimino)-[2,3'-biindolinylidene]-2'-one;3-(Hydroxyimino)-[2,3'-biindolinylidene]-2'-one;Indirubin-3-monoxime - CAS 160807-49-8 - Calbiochem
- CBNumber:
- CB1325944
- Molecular Formula:
- C16H11N3O2
- Molecular Weight:
- 277.28
- MDL Number:
- MFCD02683594
- MOL File:
- 160807-49-8.mol
- MSDS File:
- SDS
| Melting point | 247-249°C |
|---|---|
| Boiling point | 532.2±50.0 °C(Predicted) |
| Density | 1.50 |
| storage temp. | room temp |
| solubility | DMSO: >10 mg/mL |
| form | solid |
| pka | 8.66±0.20(Predicted) |
| color | Dark red or brown |
| Stability | Light Sensitive |
| CAS DataBase Reference | 160807-49-8 |
| FDA UNII | X6CSG51MBQ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| WGK Germany | 3 |
INDIRUBIN-3'-MONOXIME price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I0404 | Indirubin-3′-oxime ≥98% (HPLC), solid | 160807-49-8 | 1mg | $192 | 2024-03-01 | Buy |
| Sigma-Aldrich | 402085 | Indirubin-3?-monoxime | 160807-49-8 | 1mg | $201 | 2024-03-01 | Buy |
| Alfa Aesar | J67459 | Indirubin-3'-oxime, 98% | 160807-49-8 | 5mg | $180.65 | 2024-03-01 | Buy |
| Alfa Aesar | J67459 | Indirubin-3'-oxime, 98% | 160807-49-8 | 10mg | $200 | 2021-12-16 | Buy |
| Cayman Chemical | 13314 | Indirubin-3?-monoxime ≥98% | 160807-49-8 | 1mg | $48 | 2024-03-01 | Buy |
INDIRUBIN-3'-MONOXIME Chemical Properties,Uses,Production
Description
Indirubin-
Chemical Properties
Dark Red Solid
Uses
Indirubin-3′-oxime has been used in the inhibition of glycogen synthase kinase 3 in human monocytic cell line, THP-1.
Uses
A potent inhibitor of GSK-3? (IC50=22nM). Also inhibits CDK1 (IC50=180nM) and CDK (IC50=100nM). It reversibly arrests asynchronous HBL-100 cells at G2. It induces apoptosis in the mammary carcinoma cell line MCF-7 (10üM).
Definition
ChEBI: Indirubin-3'-monoxime is a member of the class of biindoles that is indirubin in which the keto group at position 3' has undergone condensation with hydroxylamine to form the corresponding oxime. It has a role as an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor, an osteogenesis regulator, a neuroprotective agent and an anti-obesity agent. It is a member of oxindoles, a bisindole, a ring assembly, a ketoxime and an alkaloid.
Biological Activity
Protein kinase inhibitor: inhibits cyclin-dependent kinases (IC 50 = 0.18-3.33 μ M) and GSK-3 β (IC 50 = 0.19 μ M). Inhibits CDK5- and GSK-3 β -mediated tau phosphorylation, a process over-active in Alzheimer disease states. Also inhibits AMPK, LCK and SGK. Induces cell cycle arrest and inhibits cell proliferation.
Biochem/physiol Actions
Indirubin-3′-oxime is a cyclin-dependent kinase inhibitor which functions by competing with ATP for binding to the catalytic subunit; exhibits antiproliferative activity leading to G2/M arrest in many cell lines and G1/S arrest in Jurkat cells.
storage
Store at RT
References
1) Leclerc?et al. (2001),?Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors?; J. Biol. Chem.,?276?251 2) Damiens?et al. (2001),?Anti-mitotic properties of indirubin-3′-monoximine, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest; Oncogene,?20?3786 3) Kim?et al. (2011),?Indirubin-3′-monoxime, a derivative of a chinese antileukemia medicine, inhibits angiogenesis; J. Cell. Biochem.,?112?1384 4) Ding?et al. (2010),?Indirubin-3′-monoxime rescues spatial memory deficits and attenuates beta-amyloid-associated neuropathology in a mouse model of Alzheimer’s disease; Neurobiol. Dis.,?39?156
INDIRUBIN-3'-MONOXIME Preparation Products And Raw materials
Raw materials
Preparation Products
INDIRUBIN-3'-MONOXIME Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
View Lastest Price from INDIRUBIN-3'-MONOXIME manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-01 | INDIRUBIN-3'-MONOXIME
160807-49-8
|
US $3.00 / KG | 1KG | 98% | 100KG | Career Henan Chemical Co |
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- INDIRUBIN-3'-MONOXIME
160807-49-8
- US $3.00 / KG
- 98%
- Career Henan Chemical Co