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(R,S)-ANATABINE

(R,S)-ANATABINE structure

CAS No.: 2743-90-0

Chemical Name:: (R,S)-ANATABINE

Synonyms: D,L-ANATABINE;rac-Anatabine;(R,S)-ANATABINE;Nicotine USP RC A;ANATABINE, (+/-)-(RG);1,2,3,6-TETRAHYDRO-2,3'-BIPYRIDINE;Nicotine EP Impurity A as Racemate;1,2,3,6-Tetrahydro-2,3'-bipyridine;Anatabine, froM Nicotiana tabacuM L.;2,3'-Bipyridine, 1,2,3,6-tetrahydro-

CBNumber:: CB1382628

Molecular Formula:: C10H12N2

Molecular Weight:: 160.22

MDL Number:: MFCD00078278

MOL File:: 2743-90-0.mol

Last updated:2023-05-18 11:31:03

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(R,S)-ANATABINE Properties

Boiling point	136
Density	1.045±0.06 g/cm3(Predicted)
storage temp.	Amber Vial, Refrigerator, Under Inert Atmosphere
solubility	≤15mg/ml in DMSO;15mg/ml in dimethyl formamide
form	solution in ethanol.
pka	8.84±0.40(Predicted)
Stability	Hygroscopic, Light Sensitive
CAS DataBase Reference	2743-90-0

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301-H319
Precautionary statements	P264-P270-P280-P301+P310-P305+P351+P338-P337+P313
Risk Statements	25-36
Safety Statements	24/25
RIDADR	2810
HazardClass	IRRITANT
HS Code	29399990

(R,S)-ANATABINE price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR3060	Nicotine Related Compound A/EP Impurity A pharmaceutical secondary standard, certified reference material	2743-90-0	50MG	$576	2024-03-01	Buy
Sigma-Aldrich	1463326	Nicotine Related Compound A United States Pharmacopeia (USP) Reference Standard	2743-90-0	20mg	$1380	2024-03-01	Buy
Cayman Chemical	11001	(R,S)-Anatabine ≥95%	2743-90-0	5mg	$37	2024-03-01	Buy
Cayman Chemical	11001	(R,S)-Anatabine ≥95%	2743-90-0	10mg	$62	2024-03-01	Buy
Cayman Chemical	11001	(R,S)-Anatabine ≥95%	2743-90-0	50mg	$241	2024-03-01	Buy

Product number	Packaging	Price	Buy
PHR3060	50MG	$576	Buy
1463326	20mg	$1380	Buy
11001	5mg	$37	Buy
11001	10mg	$62	Buy
11001	50mg	$241	Buy

(R,S)-ANATABINE Chemical Properties,Uses,Production

Description

(R,S)-Anatabine is a minor alkaloid produced in plants of the Solanaceae family, including tobacco. The detection of (R,S)-anatabine in urine is used as an indicator of tobacco use, particularly when nicotine-containing products (gum, patches, inhalers, and medications) are also being used. (R,S)-Anatabine increases nicotine self-administration and locomotor activity in rats. Of note, (R,S)-anatabine diminishes amyloid-β production in vitro and in vivo. (R,S)-Anatabine reduces (600 μg/ml) the transcription and protein levels of β-secretase, lowering the amount of Aβ (1-40) and Aβ (1-42) in a dose dependent manner in SHSY-5Y cells. (R,S)-Anatabine also dose dependently inhibits NF-κB activation.

Chemical Properties

Light Yellow Oil

Uses

A nicotine (N412420) metabolite.

Uses

A nicotine metabolite

Uses

(R,S)-Anatabine is a metabolite of Nicotine (N412420).

in vitro

anatabine dose-dependently lowered aβ1-40 and aβ1-42 levels and reduced sappβ production without any effects on sappα levels. anatabine lowered aβ production by mainly impacting the β-cleavage of app. anatabine lowered nfκb activation. anatabine inhibited bace-1 transcription and reduced bace-1 protein levels in human neuronal like shsy-5y cells. (r,s)-anatabine also dose dependently inhibits nf-κb activation [1].

in vivo

in a transgenic mouse model of alzheimer's disease, acute treatment with anatabine for 4 days significantly lowered brain soluble aβ1-40 and aβ1-42 levels [1].

References

[1] paris d, beaulieu-abdelahad d, bachmeier c, et al. anatabine lowers alzheimer's aβ production in vitro and in vivo[j]. european journal of pharmacology, 2011, 670(2): 384-391.

(R,S)-ANATABINE Preparation Products And Raw materials

Raw materials

Preparation Products

(R,S)-ANATABINE Suppliers

Global( 104)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Nanjing jinheyou Trading Co., Ltd.	15705188088	admin@jheyou.com	CHINA	1268	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
AFINE CHEMICALS LIMITED	0571-85134551 18958018566;	info@afinechem.com	China	15377	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9634	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Hubei Jusheng Technology Co.,Ltd.	58
BOC Sciences	58
Nanjing jinheyou Trading Co., Ltd.	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
AFINE CHEMICALS LIMITED	58
Finetech Industry Limited	58

View Lastest Price from (R,S)-ANATABINE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-23	(R,S)-ANATABINE 2743-90-0	US $0.00 / g	1g	95%min	20kg/month	Nanjing jinheyou Trading Co., Ltd.

(R,S)-ANATABINE
2743-90-0
US $0.00 / g
95%min
Nanjing jinheyou Trading Co., Ltd.

2743-90-0((R,S)-ANATABINE)Related Search:

Neotuberostemonine (+/-)-ANABASINE 2,3'-Bipyridine (R,S)-ANATABINE-2,4,5,6-D4 S-(-)-ANATABINE

ANATABINE (R,S)-N-NITROSOANATABINE (R,S)-N-NITROSOANATABINE-2,4,5,6-D4 1-(3-METHYL-6-(5-METHYL-6-PHENYLPYRIDIN-3-YL)-2-PHENYL-5,6-DIHYDROPYRIDIN-1(2H)-YL)ETHANONE (R,S)-Anatabine-d4

5,5'-DIMETHYL-6,6'-DIPHENYL-1,2,3,6-TETRAHYDRO-2,3'-BIPYRIDINE 2-CHLORO-1-(3-METHYL-6-(5-METHYL-6-PHENYLPYRIDIN-3-YL)-2-PHENYL-5,6-DIHYDROPYRIDIN-1(2H)-YL)ETHANONE (R,S)-ANATABINE BITARTRATE (3-METHYL-6-(5-METHYL-6-PHENYLPYRIDIN-3-YL)-2-PHENYL-5,6-DIHYDROPYRIDIN-1(2H)-YL)(PHENYL)METHANONE (R,S)-ANATABINE

1of3

(R,S)-ANATABINE ANATABINE, (+/-)-(RG) (+/-)-Anatabine, 3-(1,2,3,6-Tetrahydropyridin-2-yl)pyridine, 2-(Pyridin-3-yl)-1,2,3,6-tetrahydropyridine Anatabine, froM Nicotiana tabacuM L. D,L-ANATABINE 1,2,3,6-TETRAHYDRO-2,3'-BIPYRIDINE Anatabine, 97%, from Nicotiana tabacum L. 1,2,3,6-Tetrahydro-2,3'-bipyridine 98% Nicotine USP RC A 1,2,3,6-tetrahydro-2,3'-bipyridine dihydrochloride 2,3'-Bipyridine, 1,2,3,6-tetrahydro- Nicotine USP Related Compound A (rac-Nicotine EP Impurity A) (R,S)Anatabine,inhibit,(R,S)-Anatabine,(R,S) Anatabine,Inhibitor rac-Anatabine Nicotine EP Impurity A as Racemate 1,2,3,6-Tetrahydro-2,3'-bipyridine 2743-90-0 27430-90-0 Aromatics Heterocycles Metabolites & Impurities Metabolites Nicotine Derivatives