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O-DESMETHYLGALANTHAMINE

CAS No.
60755-80-8
Chemical Name:
O-DESMETHYLGALANTHAMINE
Synonyms
Sanguinine;O-Demethylgalantamine;Galantamine Impurity 7;Galantamine Impurity 6;Galantamine Impurity 3;O-Demethyl-galanthamine;O-DESMETHYLGALANTHAMINE;6-O-Demethylgalanthamine;Galantamine O-Desmethyl Impurity;10-Methyl-galantham-1-ene-3,6-diol
CBNumber:
CB1712906
Molecular Formula:
C16H19NO3
Molecular Weight:
273.33
MDL Number:
MFCD07369289
MOL File:
60755-80-8.mol
Last updated:2023-07-14 17:31:46

O-DESMETHYLGALANTHAMINE Properties

Melting point 227-230°C (dec.)
Boiling point 451.9±45.0 °C(Predicted)
Density 1.37±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO: soluble
form A solid
pka 9.39±0.40(Predicted)
CAS DataBase Reference 60755-80-8
FDA UNII L7ZOW3CZ7W

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H300
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501
NFPA 704
0
4 0

O-DESMETHYLGALANTHAMINE price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D292030 O-DesmethylGalanthamine 60755-80-8 2mg $110 2021-12-16 Buy
Biosynth Carbosynth FD21272 O-Desmethyl galanthamine 60755-80-8 5mg $125 2021-12-16 Buy
AK Scientific 2925CC Sanguinine 60755-80-8 2mg $137 2021-12-16 Buy
Biosynth Carbosynth FD21272 O-Desmethyl galanthamine 60755-80-8 10mg $230 2021-12-16 Buy
AK Scientific 2925CC Sanguinine 60755-80-8 10mg $360 2021-12-16 Buy
Product number Packaging Price Buy
D292030 2mg $110 Buy
FD21272 5mg $125 Buy
2925CC 2mg $137 Buy
FD21272 10mg $230 Buy
2925CC 10mg $360 Buy

O-DESMETHYLGALANTHAMINE Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Powder

Uses

Sanguinine has a more potent acetylcholinesterase inhibitory activity than galanthamine due to an extra hydroxyl group available for potential interaction with acetylcholinesterase. Sanguinine, in turn, is 10-fold more selective than galanthamine for acetylcholinesterase (AChE) vs. butyrylcholinesterase (BuChE). The lack of AChE inhibitory activity of lycoramine and epinorlicoramine could be due to the occurrence of a double bond in ring C, which does not allow these alkaloids to have the same spatial configuration as the active alkaloids of this series.

Uses

A metabolite of Galanthamine (G188500), a selective acetylcholinesterase inhibitor.

Uses

A metabolite of Galanthamine, a selective acetylcholinesterase inhibitor

Definition

ChEBI: Sanguinine is a benzazepine.

357-70-0
60755-80-8
Synthesis of O-DESMETHYLGALANTHAMINE from Galanthamine

O-DESMETHYLGALANTHAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

O-DESMETHYLGALANTHAMINE Suppliers

Global( 65)Suppliers
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Standardpharm Co. Ltd.
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(4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-11-Methyl-6H-benzofuro[3a,3,2-ef][2]benzazepine-3,6-diol (4aS,8aS)-11-Methyl-4aα,5,9,10,11,12-hexahydro-6H-benzofuro[3a,3,2-ef][2]benzoazepine-3,6β-diol (8aS)-5,6,9,10,11,12-Hexahydro-11-methyl-4aαH-benzofuro[3a,3,2-ef][2]benzazepine-3,6β-diol 6-O-Demethylgalanthamine 10-Methyl-galantham-1-ene-3b,6-diol O-Demethyl-galanthamine Sanguinine 10-Methyl-galantham-1-ene-3,6-diol O-DESMETHYLGALANTHAMINE Galantamine O-Desmethyl Impurity Galantamine Impurity 7 O-Demethylgalantamine 6H-Benzofuro[3a,3,2-ef][2]benzazepine-3,6-diol, 4a,5,9,10,11,12-hexahydro-11-methyl-, (4aS,6R,8aS)- O-Desmethyl GalantamineQ: What is O-Desmethyl Galantamine Q: What is the CAS Number of O-Desmethyl Galantamine Q: What is the storage condition of O-Desmethyl Galantamine Q: What are the applications of O-Desmethyl Galantamine Galantamine Impurity 6 Cholinesterase (ChE),anti-acetylcholinesterase,O Desmethyl Galanthamine,Inhibitor,galanthamine-type,ODesmethyl Galanthamine,O-Desmethyl Galanthamine,alkaloids,inhibit Galantamine Impurity 3 60755-80-8 Chiral Reagents Heterocycles Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals