1-(4-Aminophenyl)cyclopentanecarbonitrile
- CAS No.
- 115279-73-7
- Chemical Name:
- 1-(4-Aminophenyl)cyclopentanecarbonitrile
- Synonyms
- KML-54;ASISCHEM D50964;1-(4-AMINOPHENYL)CYCLOPENTANECARBONITRILE;Cyclopentanecarbonitrile, 1-(4-aminophenyl)-;1-(4-aminophenyl)-1-cyclopentanecarbonitrile;1-(4-aminophenyl)cyclopentane-1-carbonitrile;1-(4-aminophenyl)cyclopentanecarbonitrile(SALTDATA: FREE)
- CBNumber:
- CB1799242
- Molecular Formula:
- C12H14N2
- Molecular Weight:
- 186.25
- MDL Number:
- MFCD00807534
- MOL File:
- 115279-73-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H411-H341 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501 |
| HS Code | 2926907090 |
1-(4-Aminophenyl)cyclopentanecarbonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A615550 | 1-(4-Aminophenyl)cyclopentanecarbonitrile | 115279-73-7 | 250mg | $140 | 2021-12-16 | Buy |
| Apolloscientific | OR952958 | 1-(4-Aminophenyl)cyclopentanecarbonitrile | 115279-73-7 | 250mg | $156 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA153769 | 1-(4-Aminophenyl)cyclopentanecarbonitrile | 115279-73-7 | 500mg | $160 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA153769 | 1-(4-Aminophenyl)cyclopentanecarbonitrile | 115279-73-7 | 250mg | $90 | 2021-12-16 | Buy |
| SynQuest Laboratories | 3H37-1-8W | 1-(4-Aminophenyl)cyclopentanecarbonitrile 95% | 115279-73-7 | 250mg | $184 | 2021-12-16 | Buy |
1-(4-Aminophenyl)cyclopentanecarbonitrile Chemical Properties,Uses,Production
Uses
1-(4-Aminophenyl)cyclopentanecarbonitrile-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is a labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
Synthesis
1-(4-Aminophenyl)cyclopentanecarbonitrile is synthesised using 1-(4-nitrophenyl)cyclopentanecarbonitrile as a raw material by chemical reaction. The specific synthesis steps are as follows:
General procedure: The kilogram-scale reaction was performed in a 50 L single-deckglass reactor with the following conditions: 3 m (3 kg, 6.3 mol), FeO(OH)/C (460 g, 0.63 mol, 0.1 equiv), ethanol (20 L) and 80% N2H4H2O(800 g, 12.6 mol, 2 equiv) were added to a 50 L single-deck glass reactorat N2 atmosphere, then rising up the temperature to 75 C. The reactantwas stirred at 75 C for about 5 h. After the reaction was finished, the FeO(OH)/C catalyst was filtered off and washed with dichloromethane(5 L). The solvents were removed in vacuo and dried overnight byvacuum drying oven to get off-white powder 4m (2.67 kg, 6 mol), withHPLC purity >99.5%, yield 92.5%.
1-(4-Aminophenyl)cyclopentanecarbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12470 | 58 |
| WEIFANG OUCHEM TRADE CO.,LTD. | +86-18506360988 +86-18506360988 | wtaili@ouchem.cn | China | 45 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Chengdu Feibo Pharm Technology Co., Ltd | 15982321820 | abby@arkpharm.com | CHINA | 3279 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| Wuhan Konberd Biotech Co., Ltd | +undefined18986093962 | admin@konberdbio.com | China | 1376 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
View Lastest Price from 1-(4-Aminophenyl)cyclopentanecarbonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-01-25 | 1-(4-Aminophenyl)cyclopentanecarbonitrile
115279-73-7
|
US $0.00-0.00 / kg | 0.1kg | 98% Min. | 500kg | WEIFANG OUCHEM TRADE CO.,LTD. | |
 |
2023-09-19 | ASISCHEM D50964
115279-73-7
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-09-19 | ASISCHEM D50964
115279-73-7
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- 1-(4-Aminophenyl)cyclopentanecarbonitrile
115279-73-7
- US $0.00-0.00 / kg
- 98% Min.
- WEIFANG OUCHEM TRADE CO.,LTD.
-
- ASISCHEM D50964
115279-73-7
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- ASISCHEM D50964
115279-73-7
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd