ChemicalBook >> CAS DataBase List >>Docarpamine
Docarpamine
- CAS No.
- 74639-40-0
- Chemical Name:
- Docarpamine
- Synonyms
- TA 870;TA-8704;Tanadopa;Docarpamine;3,4-Bis[(ethoxycarbonyl)oxy]-N-(N-acetyl-L-methionyl)benzeneethanamine;4-{2-[(N-Acetyl-L-methionyl)amino]ethyl}-1,2-phenylenediethylbiscarbonate;(S)-2-(Acetylamino)-N-[3,4-bis(ethoxycarbonyloxy)phenethyl]-4-(methylthio)butanamide;Carbonic acid, 4-[2-[[(2S)-2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester;Carbonic acid, 4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester, (S)-;Carbonic acid, C,C'-[4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene] C,C'-diethyl ester
- CBNumber:
- CB21178560
- Molecular Formula:
- C21H30N2O8S
- Molecular Weight:
- 470.54
- MDL Number:
- MFCD00867115
- MOL File:
- 74639-40-0.mol
Last updated:2023-05-04 17:34:41
| Melting point | 85-90°; mp 105-108° (Nishiyama, 1992) |
|---|---|
| alpha | D20 -15.6° (c = 2 in methanol) |
| Boiling point | 731.0±60.0 °C(Predicted) |
| Density | 1.222±0.06 g/cm3(Predicted) |
| pka | 14.51±0.46(Predicted) |
| FDA UNII | RPQ57D8S72 |
SAFETY
Risk and Safety Statements
| Toxicity | LD50 in male, female rats (mg/kg): 1000-1400, ~1000 s.c.; in rats, dogs (mg/kg): _>2000 orally (Nishiyama, 1992) |
|---|
Docarpamine Chemical Properties,Uses,Production
Description
Docarpamine is a cardiostimulant with diuretic activity launched in Japan for the treatment of circulatory insufficiency. It is an orally effective peripheral dopamine prodrug that is well absorbed from the gastrointestinal tract and converted to dopamine in vivo, which exerts renal vasodilatory and natriuretic effects by activating renal dopamine (DA1) receptors, and a positive inotropic effect by activating cardiac β1-receptors. It has been reported to be effective in treating patients with acute heart failure, shock and acute renal failure.
Originator
Tanabe Seiyaku (Japan)
Uses
Docarpamine maybe a usefule alternative to intravenous dopamine after cardiac surgery.
Definition
ChEBI: Docarpamine is an organic molecular entity.
brand name
Tanadopa
Docarpamine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 11)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| RR Scientific LLC | +86-13917743231 | sales@rrscientific.com | United States | 878 | 58 |
| Weifu (Shanghai) Pharmaceutical Technology Co., LTD | 021-57609736 13524092974; | info@shanghaiweifu.cn | China | 232 | 58 |
| SHANGHAI HOHANCE CHEMICAL CO.,LTD | 021-31115312 18217084087 | mary@hohance.com | China | 139 | 62 |
| Chemipanda Bio-Tech Co., Ltd. | +86-571-85224801; 13588483690 | chemipanda2010@163.com | China | 110 | 62 |
| Hubei Shishun Biotechnology Co. Ltd | 027-59223025 15107168801 | 1718480011@qq.com | China | 9981 | 58 |
| Hubei Guangao Biotechnology Co., Ltd | 027-027-59223056 18162699093 | 1208480011@qq.com | China | 9951 | 58 |
| Hubei Qifei Pharmaceutical Chemical Co., Ltd | 027-59322506 18071128681 | 1400858811@qq.com | China | 9995 | 58 |
| R.R Scientific, LLC. | 15010167677 | zhiyuu1218@163.com | China | 876 | 58 |
| Shaanxi Didu New Material Co., Ltd | 029-63373950 15353716720 | 1052@dideu.com | China | 10011 | 58 |
74639-40-0(Docarpamine)Related Search:
Docarpamine
Carbonic acid, 4-[2-[[(2S)-2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester
Carbonic acid, 4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester, (S)-
TA 870
Tanadopa
(S)-2-(Acetylamino)-N-[3,4-bis(ethoxycarbonyloxy)phenethyl]-4-(methylthio)butanamide
3,4-Bis[(ethoxycarbonyl)oxy]-N-(N-acetyl-L-methionyl)benzeneethanamine
TA-8704
Carbonic acid, C,C'-[4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene] C,C'-diethyl ester
4-{2-[(N-Acetyl-L-methionyl)amino]ethyl}-1,2-phenylenediethylbiscarbonate
74639-40-0
C21H30N2O8S