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TETRODOTOXIN CITRATE

TETRODOTOXIN CITRATE Structure
TETRODOTOXIN CITRATE structure
CAS No.
18660-81-6
Chemical Name:
TETRODOTOXIN CITRATE
Synonyms
TETRODOTOXIN;TETRODOTOXIN CITRATE;citratodetetrodotoxina;tetrodotoxin,citrate(1:1)(salt);Tetrodotoxin(TTX), with citrate;Citrato de tetrodotoxina [spanish];Tetrodotoxin, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt) (9ci);Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentolcitrat;OCTAHYDRO-12-(HYDROXYMETHYL)-2-IMINO-5,9:7,10A-DIMETHANO-10AH-[1,3]DIOXOCINO[6,5-D]PYRIMIDINE-4,7,10,11,12-PENTOL CITRATE;(5R,6R,7S,9R,11R,12R,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol 2-hydroxypropane-1,2,3-tricarboxylate (1:1) (non-preferred name)
CBNumber:
CB2192024
Molecular Formula:
C17H25N3O15
Molecular Weight:
511.39
MDL Number:
MFCD00210218
MOL File:
18660-81-6.mol
Last updated:2023-06-30 15:45:59
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TETRODOTOXIN CITRATE Properties

storage temp. Desiccate at -20°C
solubility Citrate Buffer (pH 4.8): 30 mg/ml (100 mM)
form A solid
pka 8.76(at 25℃)
Water Solubility Soluble to 100 mM in water
Stability Unstable in Acidic solution, Unstable In Acidic Solution
FDA UNII 3KUM2721U9
NCI Drug Dictionary tetrodotoxin

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H300-H330-H310
Precautionary statements  P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501
Hazard Codes  T+
Risk Statements  26/27/28
Safety Statements  22-36/37/39-45
RTECS  IO1450000
Toxicity A toxin contained in the ovary and liver of puffer fish, in the eggs of the California newt and in some other animals. It is used as a chemical tool for the study of ion channels. The s.c. LD50 in mice is 10 mg/kg. It is a toxicant of nerve and muscle by blocking sodium channels, this action causing nerve and muscle paralysis. Symptoms include weakening of voluntary muscles, respiratory failure from paralysis of the diaphragm and hypotension. There is no antidote. Therapy involves artificial respiration.
NFPA 704
0
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TETRODOTOXIN CITRATE price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 14964 Tetrodotoxin (citrate) 18660-81-6 1mg $254 2024-03-01 Buy
Tocris 1078 Tetrodotoxin 18660-81-6 1 $231 2021-12-16 Buy
Tocris 1069 Tetrodotoxincitrate 18660-81-6 1 $242 2021-12-16 Buy
Biosynth Carbosynth FT64082 Tetrodotoxin citrate 18660-81-6 1mg $200 2021-12-16 Buy
Biosynth Carbosynth FT64082 Tetrodotoxin citrate 18660-81-6 2mg $340 2021-12-16 Buy
Product number Packaging Price Buy
14964 1mg $254 Buy
1078 1 $231 Buy
1069 1 $242 Buy
FT64082 1mg $200 Buy
FT64082 2mg $340 Buy

TETRODOTOXIN CITRATE Chemical Properties,Uses,Production

Description

TTX is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through voltage-activated sodium (Nav) channels, blocking nerve and muscle action potentials. It inhibits the Nav current in frog muscle and squid axon with IC50 values of 4.1 and 5.2 nM, respectively, and binds to rat brain membranes with a Kd value of 1.8 nM. TTX was used in Hodgkin and Huxley’s classic experiments to elucidate the physical biology of nerve action potentials and remains an indispensible neuroscience tool to pharmacologically dissect the contribution of the Nav current in excitable neurons and to rationally design compounds for the treatment of neuropathic pain. This citrate-stabilized form of TTX is designed for improved solubility over pure TTX , which is insoluble in water and most organic solvents. This preparation of TTX citrate consists of TTX that has been dissolved in a citrate solution and then lyophilized.

Uses

Tetrodotoxin Citrate is a highly selective, reversible sodium channel blocker.

Biological Activity

Highly selective, reversible sodium channel blocker; citrate salt of tetrodotoxin.

storage

Store at -20°C

TETRODOTOXIN CITRATE Preparation Products And Raw materials

Raw materials

Preparation Products

TETRODOTOXIN CITRATE Suppliers

Global( 41)Suppliers
Supplier Tel Email Country ProdList Advantage
TopScience Biochemical 		00852-68527855 info@itopbiochem.com China Hong Kong 902 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58
PT CHEM GROUP LIMITED 		+86-85511178 +86-85511178 peter68@ptchemgroup.com China 35453 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490 info@gihichemicals.com China 50000 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43348 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
Musechem +1-800-259-7612 info@musechem.com United States 4662 60
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684 sales@rrkchem.com China 55896 58
Supplier Advantage
TopScience Biochemical 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
PT CHEM GROUP LIMITED 		58
GIHI CHEMICALS CO.,LIMITED 		58
LEAPCHEM CO., LTD. 		58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
EMMX Biotechnology LLC 60
Musechem 60
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58

18660-81-6(TETRODOTOXIN CITRATE)Related Search:

ACONITINE TETRODOTOXIN-SENSITIV TETRODOTOXIN CITRATE (TETRAHYDRO-2H-PYRAN-3-YL)METHANAMINE HYDROCHLORIDE 2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL 1,4-Cyclohexanedimethanol
2-Amino-2-ethyl-1,3-propanediol TRANS-2-AMINOMETHYL-1-CYCLOHEXANOL TETRODOTOXIN BIS(3-AMINOPROPYL) ETHER 4-(2-AMINOETHYL)TETRAHYDROPYRAN
Ammonium citrate dibasic (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL Ammonium citrate tribasic METHYL-(TETRAHYDRO-PYRAN-3-YLMETHYL)-AMINE 5,5-DIETHOXYPENTAN-1-OL
(4-AMINO-TETRAHYDRO-PYRAN-4-YL)-METHANOL TRANS-4-(METHYLAMINO)CYCLOHEXANOL CIS-2-METHYLAMINO-CYCLOHEXANOL

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TETRODOTOXIN TETRODOTOXIN CITRATE OCTAHYDRO-12-(HYDROXYMETHYL)-2-IMINO-5,9:7,10A-DIMETHANO-10AH-[1,3]DIOXOCINO[6,5-D]PYRIMIDINE-4,7,10,11,12-PENTOL CITRATE citratodetetrodotoxina tetrodotoxin,citrate(1:1)(salt) Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentolcitrat Citrato de tetrodotoxina [spanish] Tetrodotoxin, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt) (9ci) Tetrodotoxin(TTX), with citrate (5R,6R,7S,9R,11R,12R,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol 2-hydroxypropane-1,2,3-tricarboxylate (1:1) (non-preferred name) 18660-81-6 C11H17N3O8C6H8O7 C17H25N3O15 Sodium channel