ChemicalBook >> CAS DataBase List >>2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V

2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V

2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V structure

CAS No.: 24418-86-8

Chemical Name:: 2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V

Synonyms: SKI V;Sphingosine Kinase Inhibitor V;2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one;2-(3,4-Dihydroxybenzylidene)benzofuran-3(2H)-one;(2Z)-2-(3,4-dihydroxybenzylidene)-1-benzofuran-3(2H)-one;3(2H)-Benzofuranone, 2-[(3,4-dihydroxyphenyl)methylene]-;(2E)-2-[(3,4-dihydroxyphenyl)methylidene]-1-benzofuran-3-one;2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V;PI3K,SKI V,Inhibitor,Apoptosis,GST-hSK,sphingosine,second,mitogenic,Phosphoinositide 3-kinase,S1P,Sphingosine kinase,kinase,SphK,inhibit,antitumor,noncompetitive,messenger,non-lipid

CBNumber:: CB22091422

Molecular Formula:: C15H10O4

Molecular Weight:: 254.24

MDL Number:: MFCD07772193

MOL File:: 24418-86-8.mol

Last updated:2023-05-04 17:34:36

Request For Quotation

2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V Properties

Boiling point	493.2±45.0 °C(Predicted)
Density	1.489±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO: 250 mg/mL (983.32 mM)
pka	8.99±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319
Precautionary statements	P280-P264-P305+P351+P338-P337+P313

2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0012759	SKIV 98.09%	24418-86-8	5mg	$280	2021-12-16	Buy
ChemScene	CS-0012759	SKIV 98.09%	24418-86-8	10mg	$450	2021-12-16	Buy
ChemScene	CS-0012759	SKIV 98.09%	24418-86-8	50mg	$1250	2021-12-16	Buy
ChemScene	CS-0012759	SKIV 98.09%	24418-86-8	100mg	$1850	2021-12-16	Buy
DC Chemicals	020427	SKIV	24418-86-8	003	$2100	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0012759	5mg	$280	Buy
CS-0012759	10mg	$450	Buy
CS-0012759	50mg	$1250	Buy
CS-0012759	100mg	$1850	Buy
020427	003	$2100	Buy

2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V Chemical Properties,Uses,Production

Definition

ChEBI: 3',4'-dihydroxyaurone is a hydroxyaurone that is aurone which is substituted by hydroxy groups at the 3' and 4' positions; major species at pH 7.3. It shows inhibitory activity against several isoforms of the histone deacetylase complex (HDAC). It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor. It is a hydroxyaurone and a member of catechols. It is functionally related to a 2',3,4-trihydroxy-trans-chalcone.

Biological Activity

SKI V is a non-competitive, potent non-lipid sphingosine kinase (SPHK; SK) inhibitor with IC50 of 2 μM against GST-hSK. SKI V potently inhibits PI3K with IC50 of 6 μM for hPI3k. SKI V reduces the formation of the mitotic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity.

in vivo

SKI V (75 mg/kg; ip; days 1, 5, 9, 15) significantly lowers tumor growth (>50% decreased at day 18) than control animals.

< td class="col2"> IP; days 1, 5, 9, 15

Animal Model:	6-8 weeks old BALB/c female mice with JC mammary adenocarcinoma cells
Dosage:	75 mg/kg
Administration:
Result:	Tumor growth was significantly lower (>50% decreased at day 18) than tumor growth in control animals.

target

IC50: 2 μM (GST-hSK), 6 μM (hPI3k) and 80 μM (ERK2)

2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V Preparation Products And Raw materials

Raw materials

Preparation Products

2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V Suppliers

Global( 25)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9767	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 18892239720	psaitong@jm-bio.com	China	12308	58
Yujinpharma(Tianjin) Technology Co.,Ltd.	13370351217 kungfu1217@1	kungfu1217@163.com	China	9573	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Jingmo (Xiamen) Biotechnology Co., Ltd	13621943973 13515979683	sales@jamxmpharmatech.com	China	1079	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Shanghai Chaolan Chemical Technology Center	58
Beijing Jin Ming Biotechnology Co., Ltd.	58
Yujinpharma(Tianjin) Technology Co.,Ltd.	58
Shanghai Hongye Biotechnology Co. Ltd	58
DC Chemicals	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
Jingmo (Xiamen) Biotechnology Co., Ltd	58

2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V SKI V 2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one Sphingosine Kinase Inhibitor V 2-(3,4-Dihydroxybenzylidene)benzofuran-3(2H)-one 3(2H)-Benzofuranone, 2-[(3,4-dihydroxyphenyl)methylene]- (2Z)-2-(3,4-dihydroxybenzylidene)-1-benzofuran-3(2H)-one (2E)-2-[(3,4-dihydroxyphenyl)methylidene]-1-benzofuran-3-one PI3K,SKI V,Inhibitor,Apoptosis,GST-hSK,sphingosine,second,mitogenic,Phosphoinositide 3-kinase,S1P,Sphingosine kinase,kinase,SphK,inhibit,antitumor,noncompetitive,messenger,non-lipid 24418-86-8