LEU-LEU METHYL ESTER HYDROBROMIDE
- CAS No.
- 16689-14-8
- Chemical Name:
- LEU-LEU METHYL ESTER HYDROBROMIDE
- Synonyms
- LLME · HBr;H-Leu-Leu-OMe;Leu-Leu-Ome, HBr;H-LEU-LEU-OME HBR;LLOMe hydrobromide;H-Leu-Leu-OMe hydrobromide;LEU-LEU METHYL ESTER HYDROBROMIDE;Leu-Leu-Ome.HCl|H-Leu-Leu-Ome.HCl;HLeuLeuOMe . HBr,H Leu Leu OMe . HBr;L-Leucyl-L-Leucine methyl ester hydrobromide
- CBNumber:
- CB2259808
- Molecular Formula:
- C13H27BrN2O3
- Molecular Weight:
- 339.27
- MDL Number:
- MFCD00216855
- MOL File:
- 16689-14-8.mol
- MSDS File:
- SDS
| storage temp. | −20°C |
|---|---|
| solubility | Soluble in DMSO (up to 35 mg/ml) or in Water (up to 40 mg/ml) |
| form | solid |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month. |
| FDA UNII | 48TF27RT8L |
LEU-LEU METHYL ESTER HYDROBROMIDE price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L7393 | Leu-Leu methyl ester hydrobromide ≥97% (TLC) | 16689-14-8 | 500mg | $342 | 2024-03-01 | Buy |
| Chem-Impex | 08813 | Leu-Leu-OMe·HBr,97%(TLC) 97%(TLC) | 16689-14-8 | 5G | $409.64 | 2021-12-16 | Buy |
| Chem-Impex | 08813 | Leu-Leu-OMe·HBr,97%(TLC) 97%(TLC) | 16689-14-8 | 250MG | $53.2 | 2021-12-16 | Buy |
| Chem-Impex | 08813 | Leu-Leu-OMe·HBr,≥97%(TLC) ≥97%(TLC) | 16689-14-8 | 1G | $105.12 | 2021-12-16 | Buy |
| Crysdot | CD22004403 | (S)-Methyl2-((S)-2-amino-4-methylpentanamido)-4-methylpentanoatehydrobromide 95+% | 16689-14-8 | 5g | $436 | 2021-12-16 | Buy |
LEU-LEU METHYL ESTER HYDROBROMIDE Chemical Properties,Uses,Production
Description
Leu-Leu-OMe (16689-14-8) is a lysosomal damaging agent (lysosomotropic). It is condensed into a membranolytic polymer via the transpeptidase action of cathepsin C within lysosomes.1,2 May be used to induce a lysosomal damage model in cells.3,4? LLOMe-induced lysosomal damage elicits ubiquitin puncta formation on lysosomes.1 Induces apoptosis in human mast cells via lysosome destabilization leaving fibroblasts and HEK-293 cells largely resistant.5 Induces lysophagy.4
Uses
H-Leu-Leu-OMe·HBr is a useful research chemical compound used in the preparation of octapeptide derivatives and intermediates.
References
1) Maejima et al. (2013), Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury; EMBO J., 32 2336 2) Fujita et al. (2013), Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin; J. Cell Biol., 203 115 3) Chauhan et al. (2016), TRIMS and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-directed Autophagy in Endomembrane Damage Homeostasis; Dev. Cell, 39 13 4) Otomo and Yoshimori (2017), Lysophagy: A Method for Monitoring Lysosomal Rupture Followed by Autophagy-Dependent Recovery; Methods Mol. Biol. 1594 141 5) Melo et al. (2011), Lysosomal membrane permeabilization induces cell death in human mast cells; Scand. J. Immunol., 74 354
LEU-LEU METHYL ESTER HYDROBROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
LEU-LEU METHYL ESTER HYDROBROMIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15956 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Nanjing TGpeptide | +86-13347807150 +86-13347807150 | support@tgpeptide.com | China | 3279 | 58 |
| Zhejiang Hangyu API Co., Ltd | +8617531972939 | anna@api-made.com | China | 2944 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-021-64543801 13764082696 | 2355241799@qq.com | China | 42982 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |