OMadacycline (tosylate)
- CAS No.
- 1075240-43-5
- Chemical Name:
- OMadacycline (tosylate)
- Synonyms
- QTH11;Omycycline;Omacycline Mesylate;Tyrosine Impurity 22;Omadacyeline tosylate;Omadacycline tosylater;OMadacycline (tosylate);Omacycline p-toluene sulfonate;Omadacycline p-Toluenesulfonate;Omachycline p-toluene sulfonate
- CBNumber:
- CB22685931
- Molecular Formula:
- C36H48N4O10S
- Molecular Weight:
- 728.86
- MDL Number:
- MFCD28167752
- MOL File:
- 1075240-43-5.mol
| storage temp. | 4°C, protect from light |
|---|---|
| solubility | Soluble in DMSO |
| InChIKey | SETFNHZTVGTBHC-MPRIKUDSNA-N |
| SMILES | S(C1C=CC(C)=CC=1)(O)(=O)=O.O[C@@]12C(C(C(=O)N)=C(O)[C@@H](N(C)C)[C@]1([H])C[C@]1([H])CC3=C(C=C(CNCC(C)(C)C)C(O)=C3C(=O)C1=C2O)N(C)C)=O |&1:12,20,24,27,r| |
| FDA UNII | 5658Y89YCD |
OMadacycline (tosylate) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-2465 | Omadacycline(tosylate) 99.37% | 1075240-43-5 | 50mg | $1800 | 2021-12-16 | Buy |
| ChemScene | CS-2465 | Omadacycline(tosylate) 99.37% | 1075240-43-5 | 5mg | $312 | 2021-12-16 | Buy |
| ChemScene | CS-2465 | Omadacycline(tosylate) 99.37% | 1075240-43-5 | 10mg | $540 | 2021-12-16 | Buy |
| Crysdot | CD31004645 | Omadacyclinetosylate 98+% | 1075240-43-5 | 50mg | $631 | 2021-12-16 | Buy |
| Crysdot | CD31004645 | Omadacyclinetosylate 98+% | 1075240-43-5 | 5mg | $182 | 2021-12-16 | Buy |
OMadacycline (tosylate) Chemical Properties,Uses,Production
Description
Omadacycline tosylate is a semisynthetic tetracycline-class antibacterial agent, which has been designated by some as a “new-generation tetracycline” or “the first in a new class of aminomethylcyclines.” Omadacycline has been structurally modified to provide effectiveness against certain strains of bacteria that have mechanisms to resist the action of older tetracyclines. The new agent binds to the 30S ribosomal unit, blocks bacterial protein synthesis, and is generally bacteriostatic[1]. Omadacycline tosylate has broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline tosylate has been studied in acute bacterial skin and skin structure infections, community-acquired pneumonia and urinary tract infections.
Uses
OMadacycline (tosylate) is a new type of 9-aminomethylcycline drug, which is a semi-synthetic compound obtained by modifying chemical groups on the basis of minocycline. The modification can help omacycline overcome bacterial resistance. Pharmacological properties, expand the antibacterial spectrum, and improve the pharmacokinetic properties.
Biological Activity
OMadacycline (tosylate) is an aminecycline antibiotic with antibacterial activity against Gram-positive and negative aerobic bacteria and some anaerobic bacteria.
Mode of action
(1) OMadacycline (tosylate) specifically binds to the A site of the 30S subunit of the bacterial ribosome, inhibits the normal binding of aminoacyl-tRNA to this site, terminates the elongation of the peptide chain, and blocks the synthesis of proteins to produce a bacteriostatic effect.
(2) The electron-donating group (dimethylamino) of the modified group of it can improve the activity and help to overcome the bacterial efflux pump resistance mechanism.
(3) The aminomethyl modification of it can make it overcome the bacterial ribosome protection mechanism (caused by the ribosome protection protein gene TetO) and enhance oral bioavailability.
(4) But it cannot resist the effect of Tet(X) modification enzyme.
References
[1] DANIEL A. HUSSAR; Elias B C. Omadacycline tosylate, Sarecycline hydrochloride, Rifamycin sodium, and Moxidectin[J]. Journal of the American Pharmacists Association, 2019. DOI:10.1016/j.japh.2019.07.016.
OMadacycline (tosylate) Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ENBRIDGE PHARMTECH CO., LTD. | +8613812269233 | tinayang@enbridgepharm.com | China | 303 | 58 |
| Biopole Pharmatech Co., Ltd. | +8615151475053 | biopole@163.com | China | 37 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; | info@afinechem.com | China | 15377 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9635 | 58 |
| Guangzhou TongYi biochemistry technology Co.,LTD | +8613073028829 | mack@tongyon.com | China | 2996 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
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View Lastest Price from OMadacycline (tosylate) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-02-06 | Omadacycline Tosylate
1075240-43-5
|
US $0.00 / g | 1g | 0.99 | 100kg | Biopole Pharmatech Co., Ltd. |
-
- Omadacycline Tosylate
1075240-43-5
- US $0.00 / g
- 0.99
- Biopole Pharmatech Co., Ltd.