FLLL31
- CAS No.
- 52328-97-9
- Chemical Name:
- FLLL31
- Synonyms
- FLLL31;FLLL31 >=98% (HPLC);Tetramethylcurcumin;FLLL31;FLLL-31;FLLL 31;(E,E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione;(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione;(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethylhepta-1,6-diene-3,5-dione;1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethyl-, (1E,6E)-;pancreatic,FLLL-31,domain,FLLL 31,Apoptosis,Inhibitor,STAT,Tetramethylcurcumin,cancer,kinase,Curcumin,Janus,Src,anti-inflammatory,FLLL31,breast,inhibit,homology-2
- CBNumber:
- CB22731058
- Molecular Formula:
- C25H28O6
- Molecular Weight:
- 424.49
- MDL Number:
- MFCD19443859
- MOL File:
- 52328-97-9.mol
FLLL31 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | F9057 | FLLL31 ≥98% (HPLC) | 52328-97-9 | 5mg | $134 | 2024-03-01 | Buy |
| Sigma-Aldrich | F9057 | FLLL31 ≥98% (HPLC) | 52328-97-9 | 25mg | $436 | 2024-03-01 | Buy |
| Usbiological | 301048 | Tetramethylcurcumin | 52328-97-9 | 20mg | $665 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb259527 | Tetramethylcurcumin 98% | 52328-97-9 | 20mg | $596.7 | 2021-12-16 | Buy |
| ChemScene | CS-0022792 | Tetramethylcurcumin | 52328-97-9 | 5mg | $235 | 2021-12-16 | Buy |
FLLL31 Chemical Properties,Uses,Production
Biological Activity
Tetramethylcurcumin (FLLL31) is derived from curcumin and specifically inhibits phosphorylation of STAT3 by selectively binding to Janus kinase 2 and the STAT3 Src homology 2 domain. Tetramethylcurcumin has anti-inflammatory and anticancer effects.
in vitro
Tetramethylcurcumin (FLLL31; 2.5 and 5 μM; for 24 hours) downregulas STAT3 phosphorylation and DNA-binding activity in MDA-MB-231 breast and PANC-1 pancreatic cancer cells.
Tetramethylcurcumin inhibits cell viability , cell invasion. Tetramethylcurcumin is an effective inhibitor of STAT3 phosphorylation, DNA-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines.
target
| STAT3
|
FLLL31 Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 19949 | 58 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 021-61312847 13636370518 | shyysw007@163.com | China | 4941 | 60 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3989 | 66 |
| Bide Pharmatech Ltd. | 400-1647117 15221909166 | product02@bidepharm.com | China | 41438 | 60 |
| Shanghai Yongye Biotechnology Co., Ltd. | 86-021-61559134 15921386130 | 3423497944@qq.com | China | 8147 | 55 |