DEMETHOXYCURCUMIN
- CAS No.
- 22608-11-3
- Chemical Name:
- DEMETHOXYCURCUMIN
- Synonyms
- emethoxycurcumin;Demethoxycurcumin;Curcumin Desmethoxy;DEMETHOXYCURCUMIN(SH);MonodeMethoxycurcuMin;Z/E-Desmethoxycurcumin;Demethoxycurcumin (AS);(2E)-DeMethoxy CurcuMin;(E,E)-demethoxycurcumin;(1E,6E)-Demethoxycurcumin
- CBNumber:
- CB0960423
- Molecular Formula:
- C20H18O5
- Molecular Weight:
- 338.35
- MDL Number:
- MFCD03427310
- MOL File:
- 22608-11-3.mol
- MSDS File:
- SDS
| Melting point | 166～170℃ |
|---|---|
| Boiling point | 571.4±50.0 °C(Predicted) |
| Density | 1.282±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥10mg/mL |
| form | powder |
| pka | 8.31±0.46(Predicted) |
| color | orange |
| LogP | 3.113 (est) |
| EWG's Food Scores | 1 |
| FDA UNII | W2F8059T80 |
DEMETHOXYCURCUMIN price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D7696 | Demethoxycurcumin ≥98% (HPLC) | 22608-11-3 | 5mg | $100.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | 90593 | Demethoxycurcumin analytical standard | 22608-11-3 | 10mg | $387 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1173100 | Desmethoxycurcumin UnitedStatesPharmacopeia(USP)ReferenceStandard | 22608-11-3 | 30mg | $394 | 2024-03-01 | Buy |
| Cayman Chemical | 10961 | Demethoxycurcumin ≥98% | 22608-11-3 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 10961 | Demethoxycurcumin ≥98% | 22608-11-3 | 5mg | $100 | 2024-03-01 | Buy |
DEMETHOXYCURCUMIN Chemical Properties,Uses,Production
Uses
The demethoxy derivative of Curcumin (C838500) that regulates anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. It attenuates the Wnt/β-catenin pathway through do wn-regulation of the transcriptional coactivator p300.
Uses
Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin. More stable than curcumin in physiological media, DMC suppresses proliferation in cancer cells at 50-100 μM. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits lipopolysaccharide induction of iNOS.
Definition
ChEBI: Demethoxycurcumin is a beta-diketone that is curcumin in which one of the methoxy groups is replaced by hydrogen. It is found in Curcuma zedoaria and Etlingera elatior. It has a role as a metabolite, an antineoplastic agent and an anti-inflammatory agent. It is a polyphenol, a beta-diketone, an enone and a diarylheptanoid.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biochem/physiol Actions
Demethoxycurcumin (DMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. DMC inhibits LPS-induced nitric oxide (NO) production, and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. DMC also inhibits NF-kB dependent iNOS, TNFα and IL-1β expression in LPS-treated rat microglial cells. DMC suppresses expression of MMPs and ICAM-1 in MDA-MB-231 human breast cancer cells by inhibition of NF-kB.
DEMETHOXYCURCUMIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8348 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
View Lastest Price from DEMETHOXYCURCUMIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-24 | Demethoxycurcumin
22608-11-3
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2021-07-02 | DEMETHOXYCURCUMIN
22608-11-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2019-07-06 | DEMETHOXYCURCUMIN
22608-11-3
|
US $1.00 / kg | 1g | 99% | 100KG | Career Henan Chemical Co |
-
- Demethoxycurcumin
22608-11-3
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- DEMETHOXYCURCUMIN
22608-11-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- DEMETHOXYCURCUMIN
22608-11-3
- US $1.00 / kg
- 99%
- Career Henan Chemical Co