Adavivint
- CAS No.
- 1467093-03-3
- Chemical Name:
- Adavivint
- Synonyms
- CPD1633;SM04690;Adavivint;Lorecivivint;SM-04690;SM 04690;SM04690;Wnt,SM 04690,Adavivint,SM04690,Lorecivivint,SM-04690,inhibit,Inhibitor;N-(5-(3-(7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide;Butanamide, N-[5-[3-[7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-1H-indazol-5-yl]-3-pyridinyl]-3-methyl-
- CBNumber:
- CB23137556
- Molecular Formula:
- C29H24FN7O
- Molecular Weight:
- 505.55
- MDL Number:
- MFCD30489411
- MOL File:
- 1467093-03-3.mol
| Density | 1.365±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO:27.5(Max Conc. mg/mL);54.4(Max Conc. mM) |
| pka | 7.75±0.40(Predicted) |
| FDA UNII | 42EK42WHI5 |
Adavivint price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0031495 | Adavivint 99.12% | 1467093-03-3 | 5mg | $100 | 2021-12-16 | Buy |
| ChemScene | CS-0031495 | Adavivint 99.12% | 1467093-03-3 | 10mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-0031495 | Adavivint 99.12% | 1467093-03-3 | 25mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-0031495 | Adavivint 99.12% | 1467093-03-3 | 100mg | $750 | 2021-12-16 | Buy |
| ChemScene | CS-0031495 | Adavivint 99.12% | 1467093-03-3 | 50mg | $450 | 2021-12-16 | Buy |
Adavivint Chemical Properties,Uses,Production
Uses
Adavivint is an intra-articular potential disease-modifying osteoarthritis drug.
Biological Activity
Adavivint (SM04690) is a potent canonical Wnt signaling pathway inhibitor with EC50 of 19.5 nM for TCF/LEF reporter gene. It was more potent than other known Wnt inhibitors in multiple cellular experiments.
in vitro
Treatment of bone marrow-derived human mesenchymal stem cells (CD29+, CD44+ CD166+ CD105+ CD45-) with SM04690 induced a concentration-dependent decrease in Wnt pathway gene expression (ASCL1, LEF1, TCF7L2, TCF7 , C-262 MYC and AXIN2). Selective activation of Wnt signaling pathway with Wnt3a or GSK3β inhibitor CHIR-99021, in IEC6 (intestinal stem cells sensitive to Wnt activation), M04690 can inhibit the expression of AXIN2 and LGR5; in hMSCs, inhibit the expression of AXIN2, TCF7 and LEF1 Express. It has minimal effects on non-canonical Wnt signaling and BMP signaling. In vitro, SM04690 protects chondrocytes from metabolic breakdown.
in vivo
Intra-articular injection of Adavivint promotes cartilage growth and improves joint health in a rat model of knee osteoarthritis. In vivo, it reduces cartilage breakdown.
target
| Target | Value | ||||
| Wnt () |
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| R&D Scientific Inc. | +12266000236 | sales@rdscientific.com | Canada | 1316 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4604 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3423 | 58 |