ChemicalBook >> CAS DataBase List >>ABBV-744
ABBV-744
- CAS No.
- 2138861-99-9
- Chemical Name:
- ABBV-744
- Synonyms
- CS-2875;CPD1639;ABBV-744;ABBV-744 (ABBV744);ABBV-744; ABBV 744; ABBV744;2138861-99-9;N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-h ydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-1H,6H, 7H-pyrrolo[2,3-c]pyridine-2-carboxamide;N-Ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-hydroxy-1-methylethyl)phenyl]-6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide;1H-Pyrrolo[2,3-c]pyridine-2-carboxamide, N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-hydroxy-1-methylethyl)phenyl]-6,7-dihydro-6-methyl-7-oxo-;ABBV 744,Inhibitor,Antitumor,Selective,Oral,inhibit,Potent,Epigenetic Reader Domain,Drug-like,Human immunodeficiency virus,LNCaP,CYP3A4,ABBV-744,HIV
- CBNumber:
- CB53381028
- Molecular Formula:
- C28H30FN3O4
- Molecular Weight:
- 491.55
- MDL Number:
- MFCD31657409
- MOL File:
- 2138861-99-9.mol
Last updated:2023-06-08 09:03:02
| Boiling point | 663.7±55.0 °C(Predicted) |
|---|---|
| Density | 1.262±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMSO:33.57(Max Conc. mg/mL);68.29(Max Conc. mM) DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.51(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);61.03(Max Conc. mM) |
| form | A crystalline solid |
| pka | 13.77±0.40(Predicted) |
| FDA UNII | 9MX546E2SF |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| NFPA 704 |
|
ABBV-744 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0043318 | ABBV-744 99.48% | 2138861-99-9 | 5mg | $120 | 2021-12-16 | Buy |
| ChemScene | CS-0043318 | ABBV-744 99.48% | 2138861-99-9 | 10mg | $190 | 2021-12-16 | Buy |
| ChemScene | CS-0043318 | ABBV-744 99.48% | 2138861-99-9 | 25mg | $390 | 2021-12-16 | Buy |
| ChemScene | CS-0043318 | ABBV-744 99.48% | 2138861-99-9 | 50mg | $550 | 2021-12-16 | Buy |
| DC Chemicals | DC11452 | ABBV-744 >98% | 2138861-99-9 | 100mg | $600 | 2021-12-16 | Buy |
ABBV-744 Chemical Properties,Uses,Production
Uses
ABBV 744 is a bromodomain and extra-??terminal (BET) inhibitor used as a combination therapy for cancer treatment.
Biological Activity
ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2, BRD3 and BRD4. It can be further studied for the treatment of acute myeloid leukemia and cancer.
in vitro
ABBV-744 is a potent BDII inhibitor that inhibits BRD2/3/4. The binding preference for BDII is more than 250 times that for BDI, with favorable drug-like properties. It is also an inhibitor of the androgen receptor transduction pathway.
in vivo
The maximum tolerated dose of ABBV-744 induces tumor growth inhibition in AML and prostate cancer xenograft models.
target
| Target | Value | ||||
| BDII () |
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39009 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4691 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | 0519-85788828 13775037613 | sales@chemrenpharm.com | China | 3574 | 58 |
2138861-99-9(ABBV-744)Related Search:
ABBV-744
CPD1639
CS-2875
ABBV-744; ABBV 744; ABBV744;2138861-99-9
N-Ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-hydroxy-1-methylethyl)phenyl]-6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide
1H-Pyrrolo[2,3-c]pyridine-2-carboxamide, N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-hydroxy-1-methylethyl)phenyl]-6,7-dihydro-6-methyl-7-oxo-
N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-h ydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-1H,6H, 7H-pyrrolo[2,3-c]pyridine-2-carboxamide
ABBV 744,Inhibitor,Antitumor,Selective,Oral,inhibit,Potent,Epigenetic Reader Domain,Drug-like,Human immunodeficiency virus,LNCaP,CYP3A4,ABBV-744,HIV
ABBV-744 (ABBV744)
2138861-99-9