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(1R,2S,3S)-Aprepitant

(1R,2S,3S)-Aprepitant structure

CAS No.: 172822-28-5

Chemical Name:: (1R,2S,3S)-Aprepitant

Synonyms: SM001F;(2S,3S,1’R)-Aprepitant;Aretetan Impurity-(RSS);Aprepitant (R,S,S)-Isomer;Aprepitant Impurity - (RSS);(R,S,S)-Enantiomer Aprepitant;Aprepitant Impurity 6(R,S,S-Isomer);Aprepitant Intermediate Impurity -(RSS);Aprepitant impurity 7/(1R,2S,3S)-Aprepitant;5-([(2S,3S)-2-((R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluoro phenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one

CBNumber:: CB23146512

Molecular Formula:: C23H21F7N4O3

Molecular Weight:: 534.43

MDL Number:

MOL File:: 172822-28-5.mol

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(1R,2S,3S)-Aprepitant Properties

Density	1.51±0.1 g/cm3(Predicted)
pka	8.06±0.20(Predicted)

(1R,2S,3S)-Aprepitant price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	A729770	(2S,3S,1’R)-Aprepitant	172822-28-5	25mg	$2365	2021-12-16	Buy

Product number	Packaging	Price	Buy
A729770	25mg	$2365	Buy

(1R,2S,3S)-Aprepitant Chemical Properties,Uses,Production

Uses

(2S,3S,1’R)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic. (2S,3S,1’R)-Aprepitant is also a useful synthetic intermediate in the synthesis of morpholine tachykinin receptor antagonist prodrugs.

(1R,2S,3S)-Aprepitant Preparation Products And Raw materials

Raw materials

Preparation Products

(1R,2S,3S)-Aprepitant Suppliers

Global( 38)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23556	58
CR Corporation Lomited		fred.wen@crcorporation.cn	CHINA	12069	58
China National Standard Pharmaceutical Corporation Limited	+8615391658522	overseasales@yongstandards.com	China	11927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
S.Z. PhyStandard Bio-Tech. Co., Ltd.	0755-4000505016 13380397412	3001272453@qq.com	China	4968	50
ChemStrong Scientific Co.,Ltd	0755-0755-66853366 13670046396	sales@chem-strong.com	China	17993	56
Shanghai Kewel Chemical Co., Ltd.	021-64609169 18901607656	greensnown@163.com	China	9911	50
Nanjing XiZe Biotechnology CO., Ltd.	025-58362220 15250997978	1511893459@qq.com	China	7725	55

Supplier	Advantage
Standardpharm Co. Ltd.	58
BOC Sciences	58
ANHUI WITOP BIOTECH CO., LTD	58
CR Corporation Lomited	58
China National Standard Pharmaceutical Corporation Limited	58
Amadis Chemical Company Limited	58
S.Z. PhyStandard Bio-Tech. Co., Ltd.	50
ChemStrong Scientific Co.,Ltd	56
Shanghai Kewel Chemical Co., Ltd.	50
Nanjing XiZe Biotechnology CO., Ltd.	55

172822-28-5((1R,2S,3S)-Aprepitant)Related Search:

Aprepitant 5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Benzyl dihydrogen phosphate (2R,3R)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride

Aprepitant Impurity 19 [2R-[2aR*),3a]-2-[1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine Fosaprepitant Impurity 6 Aprepitant ent-Aprepitant

(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine Aprepitant 1,1,1-Trimethoxy-2-chloroethane Aprepitant Defluoro Aprepitant

Aprepitant Impurity B HCl Aprepitant Impurity 11 HCl Aprepitant Impurity 2

1of4

Aretetan Impurity-(RSS) 5-([(2S,3S)-2-((R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluoro phenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one 3H-1,2,4-Triazol-3-one, 5-[[2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-, [2S-[2α(S*),3β]]- (9CI) SM001F (2S,3S,1’R)-Aprepitant Aprepitant Impurity - (RSS) Aprepitant Intermediate Impurity -(RSS) Aprepitant impurity 7/(1R,2S,3S)-Aprepitant Aprepitant Impurity 6(R,S,S-Isomer) (R,S,S)-Enantiomer Aprepitant Aprepitant (R,S,S)-Isomer 3H-1,2,4-Triazol-3-one, 5-[[(2S,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro- 172822-28-5