Roquinimex
- CAS No.
- 84088-42-6
- Chemical Name:
- Roquinimex
- Synonyms
- FCF89;LS-2616;CS-1231;LINOMIDE;ABR212616;ROQUINIMEX;PNU 212616;Roquinimex(Linomide);N,1-Dimethyl-N-phenyl-2-oxo-4-hydroxy-1,2-dihydroquinoline-3-carboxamide;1,2-Dihydro-4-hydroxy-1,N-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide
- CBNumber:
- CB2391777
- Molecular Formula:
- C18H16N2O3
- Molecular Weight:
- 308.33
- MDL Number:
- MFCD00866331
- MOL File:
- 84088-42-6.mol
| Melting point | 200-204° |
|---|---|
| Boiling point | 436.2±45.0 °C(Predicted) |
| Density | 1.357±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: 11 mg/mL |
| pka | 4.50±1.00(Predicted) |
| form | solid |
| Merck | 14,8259 |
| FDA UNII | 372T2944C0 |
| NCI Drug Dictionary | Linomide |
| ATC code | L03AX02 |
Roquinimex price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | L0270 | Linomide >98.0%(HPLC) | 84088-42-6 | 10mg | $170 | 2024-03-01 | Buy |
| Alfa Aesar | J65453 | Linomide | 84088-42-6 | 10mg | $174.65 | 2024-03-01 | Buy |
| Cayman Chemical | 30206 | Roquinimex | 84088-42-6 | 5mg | $89 | 2024-03-01 | Buy |
| Cayman Chemical | 30206 | Roquinimex | 84088-42-6 | 100mg | $700 | 2024-03-01 | Buy |
| Cayman Chemical | 30206 | Roquinimex | 84088-42-6 | 10mg | $168 | 2024-03-01 | Buy |
Roquinimex Chemical Properties,Uses,Production
Description
Roquinimex is an immunomodulator with diverse biological activities. In vivo, roquinimex (80 mg/kg) increases the number of myocardial MHC class II-expressing cells, the ratio of cytotoxic to helper T cells, and survival and decreases necrotic lesion area in a mouse model of murine coxsackievirus B3-induced myocarditis. It induces IFN-γ production, reduces TNF-α and IL-1β production, prevents the development of proteinuria, and ameliorates nephritis in a mouse model of chronic graft versus host disease (GVHD). Roquinimex (300 mg/kg) decreases colonic myeloperoxidase (MPO) activity and mucosal damage in a mouse model of colitis induced by dextran sulfate (DSS; ). It also decreases tumor weight and tumor blood flow in a von Hippel-Lindau (VHL) type 2a paraganglioma mouse xenograft model.
Uses
An immunomodulator with antitumour properties. Inhibits T-cell apoptosis in vivo; also inhibits angiogenesis in rats
Uses
Biological response modifier; immunomodulator.
Definition
ChEBI: 4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide is an aromatic amide.
Biological Activity
Immunomodulator with stimulatory and antitumor properties. Inhibits in vivo apoptosis of T-cells and inhibits angiogenesis in rats in vivo .
Roquinimex Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24539 | 81 |