FOSMIDOMYCIN, SODIUM SALT
- CAS No.
- 66508-37-0
- Chemical Name:
- FOSMIDOMYCIN, SODIUM SALT
- Synonyms
- FR31564;fosmidomycin;phosphonamycin;antibioticfr31564;FR-31564, SODIUM SALT;Fosmidomycinesodiumsalt;FOSMIDOMYCIN, SODIUM SALT;Fosmidomycin sodium salt (Synonyms: FR-31564);sodiuM hydrogen(3-(N-hydroxyforMaMido)propyl)phosphonate;[3-(Formylhydroxyamino)propyl]phosphonic acid sodium salt
- CBNumber:
- CB2493341
- Molecular Formula:
- C4H11NNaO5P
- Molecular Weight:
- 207.1
- MDL Number:
- MFCD27986862
- MOL File:
- 66508-37-0.mol
- MSDS File:
- SDS
| Melting point | 189-191°C |
|---|---|
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly) |
| form | Solid |
| color | White to Beige |
| Stability | Hygroscopic |
| EWG's Food Scores | 1 |
| FDA UNII | IYI1EW66CX |
SAFETY
Risk and Safety Statements
| Hazard Codes | C |
|---|---|
| Risk Statements | 34 |
| Safety Statements | 26-27-36/37/39-45 |
FOSMIDOMYCIN, SODIUM SALT price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16000 | Fosmidomycin (sodium salt) ≥95% | 66508-37-0 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 16000 | Fosmidomycin (sodium salt) ≥95% | 66508-37-0 | 5mg | $172 | 2024-03-01 | Buy |
| Cayman Chemical | 16000 | Fosmidomycin (sodium salt) ≥95% | 66508-37-0 | 10mg | $321 | 2024-03-01 | Buy |
| Cayman Chemical | 16000 | Fosmidomycin (sodium salt) ≥95% | 66508-37-0 | 25mg | $680 | 2024-03-01 | Buy |
| TRC | F728500 | FosmidomycinSodiumSalt | 66508-37-0 | 50mg | $900 | 2021-12-16 | Buy |
FOSMIDOMYCIN, SODIUM SALT Chemical Properties,Uses,Production
Chemical Properties
White Powder
Uses
An antibiotic
Uses
The antibiotics Fosmidomycin and FR900098 are members of a unique class of phosphonic acid natural products that inhibit the nonmevalonate pathway for isoprenoid biosynthesis. Both are potent antibacterial and antimalarial compounds.
Biological Activity
fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (dxp) [1]. fosmidomycin is an antibiotic originally isolated from bacteria of the genus streptomyces.1-deoxy-d-xylulose 5-phosphate reductoisomerase is an enzyme that interconverts dxp and 2-c-methyl-d-erythritol 4-phosphate (mep) [2].fosmidomycin was active against both gram-negative and gram-positive bacteria and the human malarial parasite p. falciparum with the ic50 of 290-370 nm[3]. fosmidomycin inhibited 1-deoxy-d-xylulose 5-phosphate reductoisomerase in an alternative nonmevalonate pathway for terpenoid biosynthesis with ic50 of 8.2 nm [1]. fosmidomycin has been shown to possess activity against plasmodium falciparum in vitro and in the mouse model. in patients with acute uncomplicated plasmodium falciparum malaria, oral administration of 1,200 mg fosmidomycin every 8 h for 7 days was effective in curing uncomplicated plasmodiumfalciparum malaria in humans [4]. fosmidomycin was an effective and safe antimalarial drug [4]. the treatment was well tolerated and showed a fast parasite and fever clearance [4].
References
[1] kuzuyama t, shimizu t, takahashi s, et al. fosmidomycin, a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis[j]. tetrahedron letters, 1998, 39(43): 7913-7916.
[2] takahashi s, kuzuyama t, watanabe h, et al. a 1-deoxy-d-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-c-methyl-d-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis[j]. proceedings of the national academy of sciences, 1998, 95(17): 9879-9884.
[3] jomaa h, wiesner j, sanderbrand s, et al. inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs[j]. science, 1999, 285(5433): 1573-1576.
[4] lell b, ruangweerayut r, wiesner j, et al. fosmidomycin, a novel chemotherapeutic agent for malaria[j]. antimicrobial agents and chemotherapy, 2003, 47(2): 735-738.
FOSMIDOMYCIN, SODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
FOSMIDOMYCIN, SODIUM SALT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 | 13119157289@163.com | China | 2971 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12990 | 57 |
View Lastest Price from FOSMIDOMYCIN, SODIUM SALT manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-02 | Fosmidomycin Sodium Salt
66508-37-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2019-12-26 | FOSMIDOMYCIN, SODIUM SALT
66508-37-0
|
US $1.00 / g | 1g | ≥98% | g/kg/Ton | Career Henan Chemical Co |
-
- Fosmidomycin Sodium Salt
66508-37-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- FOSMIDOMYCIN, SODIUM SALT
66508-37-0
- US $1.00 / g
- ≥98%
- Career Henan Chemical Co