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SINOVA SL-02580

SINOVA SL-02580 Structure
SINOVA SL-02580 structure
CAS No.
357263-13-9
Chemical Name:
SINOVA SL-02580
Synonyms
CS-1404;BMS-806;BMS 806;DCC-2036;SINOVA SL-02580;BMS 806;BMS-806;BMS-806 (BMS 378806);BMS-378806 BMS378806;BMS-806; BMS 378806; BMS 806; BMS378806; BMS806;BMS 378806,BMS 806,Human immunodeficiency virus,inhibit,HIV,BMS-378806,BMS806,Inhibitor
CBNumber:
CB2818106
Molecular Formula:
C22H22N4O4
Molecular Weight:
406.43
MDL Number:
MFCD09026945
MOL File:
357263-13-9.mol
MSDS File:
SDS
Last updated:2023-05-21 10:59:17
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SINOVA SL-02580 Properties

Melting point 236 °C
Density 1.328
storage temp. Store at -20°C
solubility insoluble in H2O; insoluble in EtOH; ≥20.2 mg/mL in DMSO
form solid
pka 11.99±0.40(Predicted)
FDA UNII IMN5E6PLUK

SINOVA SL-02580 price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 18525 BMS-806 ≥98% 357263-13-9 1mg $44 2024-03-01 Buy
Cayman Chemical 18525 BMS-806 ≥98% 357263-13-9 5mg $193 2024-03-01 Buy
Cayman Chemical 18525 BMS-806 ≥98% 357263-13-9 10mg $341 2024-03-01 Buy
TRC B595905 BMS806 357263-13-9 25mg $1010 2021-12-16 Buy
ApexBio Technology B1533 BMS-378806 357263-13-9 100mg $1029 2021-12-16 Buy
Product number Packaging Price Buy
18525 1mg $44 Buy
18525 5mg $193 Buy
18525 10mg $341 Buy
B595905 25mg $1010 Buy
B1533 100mg $1029 Buy

SINOVA SL-02580 Chemical Properties,Uses,Production

Description

BMS-806 is a small molecule that inhibits the first step of HIV-1 infection by blocking the binding of host cell CD4 with viral gp120 protein. It binds the exterior envelope glycoprotein gp120 (Kd= 21.1 nM; Ki = 24.9 nM), blocking the conformational change that occurs with CD4 binding and preventing fusion of the viral and target cell membranes. BMS-806 is specific to HIV-1 irrespective of chemokine receptor preference, with no activity against HIV-2, SIV, or a panel of additional viruses.

Uses

BMS 806 is a small molecular inhibitor of HIV-1 virus which blocks the interaction between gp120 and CD4 cells.

target

CD4-gp120 interactions

References

[1] wang t1, zhang z, wallace ob, deshpande m, fang h, yang z, zadjura lm, tweedie dl, huang s, zhao f, ranadive s, robinson bs, gong yf, ricarrdi k, spicer tp, deminie c, rose r, wang hg, blair ws, shi py, lin pf, colonno rj, meanwell na. discovery of 4-benzoyl-1-[(4-methoxy-1h- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (r)-methylpiperazine (bms-378806): a novel hiv-1 attachment inhibitor that interferes with cd4-gp120 interactions. j med chem. 2003 sep 25;46(20):4236-9.

SINOVA SL-02580 synthesis

271-63-6
357263-13-9
Synthesis of SINOVA SL-02580 from 7-Azaindole

SINOVA SL-02580 Preparation Products And Raw materials

Raw materials

1,2-Ethanedione, 1-[(2R)-4-benzoyl-2-methyl-1-piperazinyl]-2-(1H-pyrrolo[2,3-b]pyridin-3-yl)- 4-BENZOYL-2-METHYL-1-[(7-OXIDO-1H-PYRROLO[2,3-B] PYRIDIN-3-YL)OXOACETYL]-PIPERAZINE METHYL 7-AZAINDOLE-3-GLYOXYLATE (R)-(-)-2-Methylpiperazine (R)-2-METHYL-4-BENZOYLPIPERAZINE
Methyl benzoate 7-Azaindole

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Preparation Products

SINOVA SL-02580 Suppliers

Global( 67)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 6011 61
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 China 1494 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7553 61
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Chembest Research Laboratories Limited 61
NCE Biomedical Co.,Ltd. 55
Haoyuan Chemexpress Co., Ltd. 61

View Lastest Price from SINOVA SL-02580 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SINOVA SL-02580 pictures 2019-12-26 SINOVA SL-02580
357263-13-9
 US $1.00 / g 1g ≥98% g/kg/Ton Career Henan Chemical Co

357263-13-9(SINOVA SL-02580)Related Search:

Benzylamine 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol Tenofovir disoproxil fumarate BMS707035 Avagacestat (BMS-708163)
AC480 (BMS-599626) BMS-754807 7-AZAINDOLE-3-CARBOXALDEHYDE SINOVA SL-02580 1-((R)-4-BENZOYL-2-METHYL-PIPERAZIN-1-YL)-2-(4-METHOXY-7-OXY-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-ETHANE-1,2-DIONE
Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI) 4-HYDROXY-7-AZAINDOLE (R)-2-METHYL-4-BENZOYLPIPERAZINE 4-METHOXY-7-AZAINDOLE

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SINOVA SL-02580 DCC-2036 BMS 806 BMS-806 BMS-806 (BMS 378806) 1-[(2R)-4-Benzoyl-2-methyl-1-piperazinyl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-1,2-ethanedione (R)-1-(4-benzoyl-2-methylpiperazin-1-yl)-2-(4-methoxy-7H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione BMS 806;BMS-806 CS-1404 BMS-806; BMS 378806; BMS 806; BMS378806; BMS806 BMS-378806 BMS378806 BMS 378806,BMS 806,Human immunodeficiency virus,inhibit,HIV,BMS-378806,BMS806,Inhibitor 1,2-Ethanedione, 1-[(2R)-4-benzoyl-2-methyl-1-piperazinyl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)- 357263-13-9 Inhibitors