Muzolimine
- CAS No.
- 55294-15-0
- Chemical Name:
- Muzolimine
- Synonyms
- Edrul;Muzolimine;BAY-g-2821;Muzolimina;Muzoliminum;3-Amino-1-(3,4-dichloro-α-methylbenzyl)-2-pyrazolin-5-one;3-amino-1-(1-(3,4-dichlorophenyl)ethyl)-1H-pyrazol-5(4H)-one;3H-Pyrazol-3-one, 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-2,4-dihydro-
- CBNumber:
- CB2875411
- Molecular Formula:
- C11H11Cl2N3O
- Molecular Weight:
- 272.13
- MDL Number:
- MFCD00867325
- MOL File:
- 55294-15-0.mol
Melting point | 127-129° |
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Boiling point | 401.4±55.0 °C(Predicted) |
Density | 1.5374 (rough estimate) |
refractive index | 1.5500 (estimate) |
pka | 3.30±0.50(Predicted) |
FDA UNII | 07Z36289ZX |
ATC code | C03CD01 |
SAFETY
Risk and Safety Statements
Toxicity | LD50 in mice, rats, dogs, rabbits (mg/kg): 1794, 1559, 2000, 1250 orally (Lorke, Mürmann) |
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Muzolimine Chemical Properties,Uses,Production
Description
Muzolimine is a structurally novel, pyrazolone diuretic with a high-ceiling profile. It is somewhat slower in onset than furosemide, but has a more prolonged effect, similar to the thiazides. Muzolimine has been shown to be effective in edema of cardiac, hepatic and renal origin. It also appears to be effective as an antihypertensive agent.
Originator
Bayer (W. Germany)
Uses
Diuretic; antihypertensive.
Definition
ChEBI: Muzolimine is a dichlorobenzene.
Manufacturing Process
41 g of α-methyl-3,4-dichlorobenzylhydrazine, dissolved in absolute ethanol, were added dropwise to a solution of 31.8 g of β-amino-β-ethoxyacrylic acid ethyl ester and 1.5 g of p-toluenesulfonic acid in 150 ml of ethanol at room temperature under nitrogen gas. After stirring for 2 hours and standing overnight, the reaction solution was concentrated as far as possible on a rotary evaporator. The residue which remained was dissolved in 2 N sodium hydroxide solution. Any unconverted starting products or by-products were extracted with ether. The aqueous phase was then brought to pH 5 with acetic acid. The oil thereby produced was taken up in methylene chloride and the organic phase was dried over Na2SO4. After evaporating off the solvent, the reaction product crystallized out. It was recrystallized from methanol; melting point 127°C to 129°C; yield 21 g (38.5% of theory).
brand name
EDRUL
Therapeutic Function
Diuretic
World Health Organization (WHO)
Reports of neurological adverse effects, including paraesthesiae and paralyses, associated with prolonged use of high dosages of muzolimine, were received shortly after its introduction in 1984.
Muzolimine Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 992 | 58 |
Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9020 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Hangzhou Synstar pharmaceutical Technology CO.,Ltd | 0571-85361029 | synstar518@163.com | China | 1991 | 58 |
BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |