4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine
![4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine Structure](CAS/GIF/346688-38-8.gif)
- CAS No.
- 346688-38-8
- Chemical Name:
- 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine
- Synonyms
- ACR 16;Huntexil;ASP 2314;FR 310826;Pridopidine;Acr16 compound;4-(3-Methylsulfonylphenyl)-1-propylpiperidine;4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine;4-(3-Methanesulfonyl-phenyl)-1-propyl-piperidine;Piperidine, 4-(3-(methylsulfonyl)phenyl)-1-propyl-
- CBNumber:
- CB31175814
- Molecular Formula:
- C15H23NO2S
- Molecular Weight:
- 281.41
- MDL Number:
- MFCD09835586
- MOL File:
- 346688-38-8.mol
- MSDS File:
- SDS
| Melting point | 73-750C |
|---|---|
| Boiling point | 434.2±45.0 °C(Predicted) |
| Density | 1.092±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO (up to 10 mg/ml). |
| pka | 9.09±0.10(Predicted) |
| form | solid |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| FDA UNII | HD4TW8S2VK |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H361d |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M326195 | 4-(3-Methylsulfonylphenyl)-1-propylpiperidine | 346688-38-8 | 5mg | $175 | 2021-12-16 | Buy |
| TRC | M326195 | 4-(3-Methylsulfonylphenyl)-1-propylpiperidine | 346688-38-8 | 25mg | $790 | 2021-12-16 | Buy |
| ChemScene | CS-0002733 | Pridopidine 99.77% | 346688-38-8 | 5mg | $140 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0011418 | 4-[3-(METHYLSULFONYL)PHENYL]-1-PROPYLPIPERIDINE 95.00% | 346688-38-8 | 5MG | $774.4 | 2021-12-16 | Buy |
| ChemScene | CS-0002733 | Pridopidine 99.77% | 346688-38-8 | 25mg | $540 | 2021-12-16 | Buy |
4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine Chemical Properties,Uses,Production
Description
Pridopidine (346688-38-8) is being studied as a potential treatment for Huntington’s disease, Parkinson’s disease, and schizophrenia based on its locomotor stabilizing and antipsychotic-like effects.1,2?It was, unusually, able to reverse both hypo- and hyperdopaminergia depending on local dopamine concentrations without inducing catalepsy. This was originally attributed to functional dopamine D2 antagonism with fast on/off kinetics (“dopamine stabilizer”).3?More recent studies have attributed pridopidine’s effects to its being a more potent sigma-1 ligand than a D2 ligand.4,5?Displays neuroprotective/restorative effects6,7?and ameliorates central features of amyotrophic lateral sclerosis pathology8?in a sigma-1-mediated manner
Chemical Properties
4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine is Off-White Solid
Uses
4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine is a new modulator of dopamine neurotransmission. Dopamine is a neurotransmitter in the brain. Drugs that act at central dopamine receptors are commonly used in the treatment of neurologic and psychiatric disorders.
storage
Store at -20°C
References
1) Pettersson (2010),?Synthesis and Evaluation of a Set of 4-Phenylpiperidines and 4-Phenylpiperazines as D2 Receptor Ligands and the Discovery of the Dopaminergic Stabilizer 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine (Huntexil, Pridopidine, ACR16);?J.Med.Chem.?53?2510 2)?The dopamine stabilizers (S)-(-)-(3-methanesulfonylphenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonylphenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potential for motor side effects in the rat;?J.Pharmacol.Exp.Ther.?318?810 3) Dyhring?et al.?(2010)?The dopaminergic stabilizers pridopidine (ACR16) and (-)-OSU6162 display dopamine D(2) receptor antagonism and fast receptor dissociation properties;?Eur.J.Pharmacol.?628?19 4) Sahlholm (2015)?Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses;?Psychopharmacology (Berl)?232?3443 5)?Sahlholm?et al.?(2013),?The dopamine stabilizers ACR16 and (-)-OSU6162 display nanomolar affinities at the?s-1 receptor;?Mol.Psychiatry?18?12 6) Francardo?et al.?(2019),?Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson’s Disease;?Neurotherapeutics?16?465 7) Ryskamp,?et al.?(2017),?The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease;?Neurobiol.Dis.?97(Pt A)?46 8) Ionescu?et al.?(2019),?Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model;?Cell Death Dis.?10?210
4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
| Jiangsu yize medical technology co. LTD | 18550739526 | 3394205705@qq.com | China | 1908 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Yangzhou Siyu Chemical Co.,Ltd. | 0514-87325867 | sales@siyuchem.com | China | 370 | 55 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6010 | 61 |