Butopamine
- CAS No.
- 66734-12-1
- Chemical Name:
- Butopamine
- Synonyms
- LY-131126;Butopamine;Compound LY-131126;4-[(R)-3-[[(R)-2-(4-Hydroxyphenyl)-2-hydroxyethyl]amino]butyl]phenol;(R)-4-Hydroxy-α-[[(R)-3-(4-hydroxyphenyl)-1-methylpropylamino]methyl]benzyl alcohol;Benzenemethanol, 4-hydroxy-α-[[[(1R)-3-(4-hydroxyphenyl)-1-methylpropyl]amino]methyl]-, (αR)-
- CBNumber:
- CB31178198
- Molecular Formula:
- C18H23NO3
- Molecular Weight:
- 301.38
- MDL Number:
- MFCD00867138
- MOL File:
- 66734-12-1.mol
| Boiling point | 520.5±50.0 °C(Predicted) |
|---|---|
| Density | 1.189±0.06 g/cm3(Predicted) |
| pka | 9.97±0.26(Predicted) |
| FDA UNII | ZX7907IE2H |
Butopamine Chemical Properties,Uses,Production
Originator
Butopamine,ZYF Pharm Chemical
Definition
ChEBI: A 4-(1-hydroxy-2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)phenol in which both stereocentres have R configuration. It is the most active of the four diastereoisomers that make up the animal feed additive ractopamine.
Manufacturing Process
A solution of 32.8 g (0.2 m) of methyl 2-(4-hydroxyphenyl)ethyl ketone and
42.6 g (0.2 m) of 1-(4-hydroxyphenyl)-2-aminoethanol in 380 ml of ethanol containing 3.8 g of 5% palladium on carbon was stirred for 16 h at 60°C
under hydrogen at 55 psi. The reaction mixture was then filtered, and the
filtrate was diluted by addition of 350 ml of water. The aqueous mixture was
concentrated to a volume of about 400 ml, and then washed with
dichloromethane.
The aqueous mixture was acidified by addition of 50 ml of conc. hydrochloric
acid. After standing at room temperature for 2 h, the aqueous acid mixture
was filtered and the filter cake was washed with 40 ml of ice water and dried
at 50°C in vacuum to provide 47.0 g of 1-(4-hydroxyphenyl-2-
propylamino]ethanol hydrochloride, melting point 124-129°C.
The 1-(4-hydroxyphenyl)-2-[1-methyl-3-(4-hydroxyphenyl)propylamino]
ethanol was obtained by treatment of 1-(4-hydroxyphenyl-2-
propylamino]ethanol hydrochloride with sodium hydroxide.
Therapeutic Function
Cardiotonic
Butopamine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Butopamine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
| Supplier | Advantage |
|---|---|
| Hangzhou MolCore BioPharmatech Co.,Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |