ChemicalBook >> CAS DataBase List >>Imipenem-Cilastatin sodium hydrate
Imipenem-Cilastatin sodium hydrate
- CAS No.
- 92309-29-0
- Chemical Name:
- Imipenem-Cilastatin sodium hydrate
- Synonyms
- Thienam;Primaxin;Tienam 500;Mk 787-mk 791 mixture;Mk 0787-mk 0791 mixture;85960-17-4 (Hydrochloride salt);Imipenem-Cilastatin sodium hydrate;Imipenem-Cilastatin sodium hydrate USP/EP/BP;IMipeneM and Cilastatin SodiuM with SodiuM Bicarbonate;TIANFU-CHEM CAS:92309-29-0 Imipenem-Cilastatin sodium hydrate
- CBNumber:
- CB31261281
- Molecular Formula:
- C28H43N5O9S2
- Molecular Weight:
- 657.8
- MDL Number:
- MOL File:
- 92309-29-0.mol
Imipenem-Cilastatin sodium hydrate Chemical Properties,Uses,Production
Clinical Use
Antibacterial agent
Drug interactions
Potentially hazardous interactions with other drugs
Antiepileptics: reduced valproate concentration -
avoid.
Antivirals: convulsions reported with concomitant
administration of ganciclovir and valganciclovir.
Ciclosporin: variable reports of increase / no change
in ciclosporin levels, and of neurotoxicity.
Metabolism
When administered alone, imipenem is metabolised in the kidneys by dehydropeptidase-I, an enzyme in the brush border of the renal tubules, to inactive, nephrotoxic metabolites, with only about 5 to 40 or 45% of a dose excreted in the urine as unchanged active drug. Cilastin inhibits the metabolism of imipenem. When given with cilastatin about 70% of an intravenous dose of imipenem is recovered unchanged in the urine within 10 hours. Cilastatin is also excreted mainly in the urine, the majority as unchanged drug and about 12% as N-acetyl cilastatin. Less than 1% of imipenem is excreted via the bile in the faeces.
Imipenem-Cilastatin sodium hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 57)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15956 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9126 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; | info@afinechem.com | China | 15377 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 +86-13986145403 | info@fortunachem.com | China | 6004 | 58 |
| Hebei Duling International Trade Co. LTD | +8618712993135 | sales01@hbduling.cn | China | 15738 | 58 |
View Lastest Price from Imipenem-Cilastatin sodium hydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-09-29 | Imipenem-Cilastatin sodium hydrate
92309-29-0
|
US $0.00 / KG/Tin | 5KG | Imipenem≥400μg/mg，Cilastatin(C16H26N2O5S) ≥400μg/mg;USP | 100KGS | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2019-08-08 | Imipenem-Cilastatin sodium hydrate
92309-29-0
|
US $3.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- Imipenem-Cilastatin sodium hydrate
92309-29-0
- US $0.00 / KG/Tin
- Imipenem≥400μg/mg，Cilastatin(C16H26N2O5S) ≥400μg/mg;USP
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Imipenem-Cilastatin sodium hydrate
92309-29-0
- US $3.00 / KG
- 99%
- Career Henan Chemical Co
92309-29-0(Imipenem-Cilastatin sodium hydrate)Related Search:
Primaxin
Thienam
Tienam 500
IMipeneM and Cilastatin SodiuM with SodiuM Bicarbonate
7-[(2S)-2-amino-2-carboxy-ethyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopro panecarbonyl]amino]hept-2-enoic acid: (5R)-3-[2-(aminomethylideneamino )ethylsulfanyl]-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene -2-carboxylic acid
Imipenem-Cilastatin sodium hydrate
Sodium (Z)-7-[(2R)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoate (5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate
1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 6-((1R)-1-hydroxyethyl)-3-((2-((iminomethyl)amino)ethyl)thio)-7-oxo-, (5R,6S)-, mixt. with (2Z)-7-(((2R)-2-amino-2-carboxyethyl)thio)-2-((((1S)-2,2-dimethylcyclopropyl)carbonyl)amino)-2-heptenoic acid
1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-3-((2-((iminomethyl)amino)ethyl)thio)-7-oxo-, (5R-(5alpha,6alpha(R*)))-, mixt. with (R-(R*,S*-(Z)))-7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-2-heptanoic acid
85960-17-4 (Hydrochloride salt)
Mk 0787-mk 0791 mixture
Mk 787-mk 791 mixture
Imipenem-Cilastatin sodium hydrate USP/EP/BP
TIANFU-CHEM CAS:92309-29-0 Imipenem-Cilastatin sodium hydrate
(Z)-7-[(2R)-2-amino-2-carboxyethyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoicacid,(5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylicaci
92309-29-0
C28H43N5O9S2
C12H17N3O4SC16H25N2NaO5SH2O