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EGFR inhibitor

EGFR inhibitor structure

CAS No.: 879127-07-8

Chemical Name:: EGFR inhibitor

Synonyms: EGFR-IN-12;EGFR inhibitor;EGFR inhibitor 324674;EGFR inhibitor(YUN27078);EGFR Inhibitor [879127-07-8];EGFR Inhibitor [879127-07-8] - EGFR Inhibitor 324674;N-(3-((6-((3-(Trifluoromethyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)cyclopropanecarboxamide;CyclopropanecarboxaMide, N-[3-[[6-[[3-(trifluoroMethyl)phenyl]aMino]-4-pyriMidinyl]aMino]phenyl]-;EGFR,EGFRIN12,autophosphorylation,anti-proliferation,4,6-disubstituted,antitumor,kinases,Epidermal growth factor receptor,inhibit,EGFR IN 12,AKT,pyrimidine,ErbB-1,Apoptosis,Inhibitor,HER1,Tyrosine

CBNumber:: CB32597567

Molecular Formula:: C21H18F3N5O

Molecular Weight:: 413.4

MDL Number:

MOL File:: 879127-07-8.mol

MSDS File:: SDS

Last updated:2023-05-21 10:59:17

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EGFR inhibitor Properties

Boiling point	605.9±55.0 °C(Predicted)
Density	1.456±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	insoluble in H2O; insoluble in EtOH; ≥60.7 mg/mL in DMSO
form	crystalline solid
pka	14.50±0.70(Predicted)
NCI Dictionary of Cancer Terms	EGFR inhibitor

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

EGFR inhibitor price More Price(15)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	324674	EGFR Inhibitor - CAS 879127-07-8 - Calbiochem	879127-07-8	1MG	$159	2024-03-01	Buy
Cayman Chemical	15363	EGFR Inhibitor ≥98%	879127-07-8	1mg	$93	2024-03-01	Buy
Cayman Chemical	15363	EGFR Inhibitor ≥98%	879127-07-8	5mg	$275	2024-03-01	Buy
Cayman Chemical	15363	EGFR Inhibitor ≥98%	879127-07-8	25mg	$957	2024-03-01	Buy
TRC	E440158	EGFRInhibitor	879127-07-8	1mg	$115	2021-12-16	Buy

Product number	Packaging	Price	Buy
324674	1MG	$159	Buy
15363	1mg	$93	Buy
15363	5mg	$275	Buy
15363	25mg	$957	Buy
E440158	1mg	$115	Buy

EGFR inhibitor Chemical Properties,Uses,Production

Uses

EGFR Inhibitor is a highly selective, cell-permeable EGFR inhibitor.

Biological Activity

egfr inhibitor is a cell permeable, pyrimidine compound that selectively inhibits the egfr kinase with ic50 value of 21 nm [1].egfr is a transmembrane protein, and is a receptor for members of epidermal growth factor family. the binding of egfr with its ligands induces receptor dimerization and tyrosine autophosphorylation, and leads to cell proliferation. the overactivity of egfr tyrosine kinases is associated with a number of cancers, inhibition of egfr can downregulate antiapoptotic proteins such as surviving and upregulate proapoptotic proteins such as bim. thus, egfr inhibitor can induce cell apoptosis, resulting in anti-tumor effectivity [2].egfr inhibitor inhibited egfr kinase in vitro and blocks receptor autophosphorylation in cells. egfr inhibitor also inhibited l858r and l861q egfr mutants with ic50 values of 63 and 4 nm, respectively [1].

References

1. q. zhang, y. liu, f. gao, et al. discovery of egfr selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library. journal of the american chemical society 128(7), 2182-2183 (2006). 2. f. ciardiello, g. tortora. egfr antagonists in cancer treatment. new england journal of medicine 358(11), 1160-1174 (2008).

EGFR inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

EGFR inhibitor Suppliers

Global( 52)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2784	58
SPIRO PHARMA		eric_feng1954@126.com	China	9254	55

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Career Henan Chemica Co	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
VDM Biochemicals	64
AdooQ BioScience, LLC	58
SPIRO PHARMA	55

EGFR inhibitor Spectrum

EGFR inhibitor(879127-07-8)¹HNMR

EGFR inhibitor CyclopropanecarboxaMide, N-[3-[[6-[[3-(trifluoroMethyl)phenyl]aMino]-4-pyriMidinyl]aMino]phenyl]- EGFR Inhibitor [879127-07-8] EGFR-IN-12 EGFR inhibitor 324674 EGFR inhibitor(YUN27078) EGFR Inhibitor [879127-07-8] - EGFR Inhibitor 324674 N-(3-((6-((3-(Trifluoromethyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)cyclopropanecarboxamide EGFR,EGFRIN12,autophosphorylation,anti-proliferation,4,6-disubstituted,antitumor,kinases,Epidermal growth factor receptor,inhibit,EGFR IN 12,AKT,pyrimidine,ErbB-1,Apoptosis,Inhibitor,HER1,Tyrosine 879127-07-8 A EGFR tyrosine kinase inhibitor.