ChemicalBook >> CAS DataBase List >>(-)-TRAMADOL

(-)-TRAMADOL

CAS No.
181289-59-8
Chemical Name:
(-)-TRAMADOL
Synonyms
(-)-2-[(DIMETHYLAMINO)METHYL]-1-(3-METHOXYPHENYL)CYCLOHEXANOL;Cyclohexanol, 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-, (1S,2R)-
CBNumber:
CB3293436
Molecular Formula:
C16H25NO2
Molecular Weight:
263.38
MDL Number:
MFCD03701238
MOL File:
181289-59-8.mol
Last updated:2023-05-04 17:34:35

(-)-TRAMADOL Properties

Boiling point 388.1±22.0 °C(Predicted)
Density 1.047±0.06 g/cm3(Predicted)
pka 14.47±0.40(Predicted)
FDA UNII OM3T42Z3HV

(-)-TRAMADOL Chemical Properties,Uses,Production

Definition

ChEBI: (S,S)-tramadol is a 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol in which both stereocentres have S-configuration; the (S,S)-enantiomer of the racemic opioid analgesic tramadol, it exhibits ten-fold lower analgesic potency than the (R,R)-enantiomer. It has a role as a delta-opioid receptor agonist, a kappa-opioid receptor agonist, a mu-opioid receptor agonist, an adrenergic uptake inhibitor, an antitussive, a capsaicin receptor antagonist, a muscarinic antagonist, a nicotinic antagonist, a NMDA receptor antagonist, an opioid analgesic, a serotonergic antagonist and a serotonin uptake inhibitor. It is a conjugate base of a (S,S)-tramadol(1+). It is an enantiomer of a (R,R)-tramadol.

(-)-TRAMADOL Preparation Products And Raw materials

Raw materials

Preparation Products

(-)-2-[(DIMETHYLAMINO)METHYL]-1-(3-METHOXYPHENYL)CYCLOHEXANOL Cyclohexanol, 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-, (1S,2R)- 181289-59-8