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CU-CPT-9a

CAS No.
2162962-69-6
Chemical Name:
CU-CPT-9a
Synonyms
CPD1577;CU-CPT-9a;TLR8 inhibitor;cas 2162962-69-6;TLR8-specific antagonist 1;4-(4-hydroxy-3-methylphenyl)quinolin-7-ol;CU-CPT-9A;CAS 2162962-69-6;TLR8 INHIBITOR;2-Methyl-4-(7-hydroxy-4-quinolinyl)phenol;7-Quinolinol, 4-(4-hydroxy-3-methylphenyl)-;inhibit,Toll-like Receptor (TLR),CU-CPT9b,Inhibitor,CUCPT9b,CU CPT9b
CBNumber:
CB33369600
Molecular Formula:
C16H13NO2
Molecular Weight:
251.28
MDL Number:
MOL File:
2162962-69-6.mol
Last updated:2023-06-08 09:03:00

CU-CPT-9a Properties

Boiling point 452.6±45.0 °C(Predicted)
Density 1.287±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
form A crystalline solid
pka 8.46±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
NFPA 704
0
2 0

CU-CPT-9a price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 28723 CU-CPT9b 2162962-69-6 5mg $116 2024-03-01 Buy
Cayman Chemical 28723 CU-CPT9b 2162962-69-6 25mg $494 2024-03-01 Buy
Cayman Chemical 28723 CU-CPT9b 2162962-69-6 1mg $32 2024-03-01 Buy
Cayman Chemical 28723 CU-CPT9b 2162962-69-6 10mg $214 2024-03-01 Buy
Tocris 6479 CUCPT9a ≥98%(HPLC) 2162962-69-6 5 $171 2021-12-16 Buy
Product number Packaging Price Buy
28723 5mg $116 Buy
28723 25mg $494 Buy
28723 1mg $32 Buy
28723 10mg $214 Buy
6479 5 $171 Buy

CU-CPT-9a Chemical Properties,Uses,Production

Description

CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF-ĸB induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM.

Uses

CU-CPT9a is a potent TLR8 inhibitor (IC50 = 0.5 nM and Kd = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.

CU-CPT-9a Preparation Products And Raw materials

Raw materials

Preparation Products

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ATK CHEMICAL COMPANY LIMITED
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Aladdin Scientific
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Amadis Chemical Company Limited
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CPD1577 CU-CPT-9a 2-Methyl-4-(7-hydroxy-4-quinolinyl)phenol cas 2162962-69-6 CU-CPT-9A;CAS 2162962-69-6;TLR8 INHIBITOR TLR8 inhibitor TLR8-specific antagonist 1 4-(4-hydroxy-3-methylphenyl)quinolin-7-ol 7-Quinolinol, 4-(4-hydroxy-3-methylphenyl)- inhibit,Toll-like Receptor (TLR),CU-CPT9b,Inhibitor,CUCPT9b,CU CPT9b 2162962-69-6