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NDI-010976

NDI-010976 structure

CAS No.: 1434635-54-7

Chemical Name:: NDI-010976

Synonyms: ND-630;GS0976;CS-2609;CS-2632;CPDB5078;EOS-61252;NDI-010976;Firsocostat;GS0976,ND-630;ND-630（GS0976）

CBNumber:: CB73133386

Molecular Formula:: C28H31N3O8S

Molecular Weight:: 569.63

MDL Number:: MFCD28963986

MOL File:: 1434635-54-7.mol

Last updated:2023-05-21 10:59:17

Request For Quotation

NDI-010976 Properties

Boiling point	779.0±70.0 °C(Predicted)
Density	1.42±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:75.0(Max Conc. mg/mL);131.66(Max Conc. mM) DMF:10.0(Max Conc. mg/mL);17.56(Max Conc. mM) Ethanol:3.0(Max Conc. mg/mL);5.27(Max Conc. mM)
form	A crystalline solid
pka	3.66±0.10(Predicted)
FDA UNII	XE10NJQ95M

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P280-P305+P351+P338

NDI-010976 price More Price(13)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	23961	ND-630 ≥98%	1434635-54-7	1mg	$364	2024-03-01	Buy
Cayman Chemical	23961	ND-630 ≥98%	1434635-54-7	5mg	$1181	2024-03-01	Buy
AK Scientific	9222DU	Firsocostat	1434635-54-7	5mg	$1412	2021-12-16	Buy
ChemScene	CS-6509	Firsocostat 99.48%	1434635-54-7	10mg	$450	2021-12-16	Buy
American Custom Chemicals Corporation	INB0005695	(R)-2-(1-(2-(2-METHOXYPHENYL)-2-((TETRAHYDRO-2H-PYRAN-4-YL)OXY)ETHYL)-5-METHYL-6-(OXAZOL-2-YL)-2,4-DIOXO-1,2-DIHYDROTHIENO[2,3-D]PYRIMIDIN-3(4H)-YL)-2-METHYLPROPANOIC ACID 95.00%	1434635-54-7	5MG	$497.67	2021-12-16	Buy

Product number	Packaging	Price	Buy
23961	1mg	$364	Buy
23961	5mg	$1181	Buy
9222DU	5mg	$1412	Buy
CS-6509	10mg	$450	Buy
INB0005695	5MG	$497.67	Buy

NDI-010976 Chemical Properties,Uses,Production

Description

ND-630 is an allosteric inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits ACC1 and ACC2 activity (IC₅₀s = 2.1 and 6.1 nM, respectively, for the human enzymes). It is selective for ACC over 101 enzymes, receptors, growth factors, transporters, and ion channels up to a concentration of 10 μM. ND-630 prevents dimerization of ACC by interacting within the phosphopeptide-acceptor and dimerization site. It reduces fatty acid synthesis (EC₅₀s = 66 and 9 nM in 10% FBS and serum-free media, respectively) and increases fatty acid oxidation in HepG2 cells. ND-630 reduces hepatic steatosis in a rat model of diet-induced obesity and in Zucker diabetic rats. It also improves insulin secretion stimulated by glucose and reduces hemoglobin A1c levels by 0.9% in Zucker diabetic rats.

Uses

Firsocostat or ND-630 (CAS# 1434635-54-7) is an inhibitor of acetyl-coA carboxylase and may favorably affect the morbidity and mortality associated with obesity, diabetes, and fatty liver disease from reduced hepatic steatosis, improved insulin sensitivity, and modulation of dyslipidemia.

NDI-010976 Preparation Products And Raw materials

Raw materials

Preparation Products

NDI-010976 Suppliers

Global( 95)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	marketing1@neostarunited.com	China	8348	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Chemia Biotechnology（Shanghai） Co., Ltd	+8613816753574	info@chemia-pharm.com	CHINA	311	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9634	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
CR Corporation Lomited		fred.wen@crcorporation.cn	CHINA	12069	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Chemia Biotechnology（Shanghai） Co., Ltd	58
Finetech Industry Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
CR Corporation Lomited	58

View Lastest Price from NDI-010976 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2022-01-14	NDI-010976 1434635-54-7	US $0.00 / KG	1KG	97.4%	100 tons	Honest Joy Holdings Limited
	2019-07-06	NDI-010976 1434635-54-7	US $7.00 / KG	1KG	99%	100kG	Career Henan Chemical Co

NDI-010976
1434635-54-7
US $0.00 / KG
97.4%
Honest Joy Holdings Limited

NDI-010976
1434635-54-7
US $7.00 / KG
99%
Career Henan Chemical Co

1434635-54-7(NDI-010976)Related Search:

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1of2

NDI-010976 (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoicacid ND-630 (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanoic acid EOS-61252 GS0976 CPDB5078 (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3- GS0976,ND-630 1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid ND-630,NDI-010976 Firsocostat Firsocostat(ND-630,GS-0976) CS-2609 CS-2632 ND 630; ND630;GS-0976;GS 0976;GS0976;FIRSOCOSTAT Firsocostat (GS-0976,NDI-010976,ND-630) ND630;FIRSOCOSTAT Firsocostat (ND-630 Thieno[2,3-d]pyrimidine-3(2H)-acetic acid, 1,4-dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxo- ND-630（GS0976） Firsocostat (GS-0976) 1434635-54-7 API