ANILERIDINE HYDROCHLORIDE CII (250 MG)
- CAS No.
- 126-12-5
- Chemical Name:
- ANILERIDINE HYDROCHLORIDE CII (250 MG)
- Synonyms
- mk89;aldine;apodol;D02942;Leritine (tn);leritinedihydrochloride;anileridinedihydrochloride;Anileridine hydrochloride (usp);ANILERIDINE HYDROCHLORIDE CII (250 MG);Anileridine Hydrochloride CII (1036008)
- CBNumber:
- CB3501629
- Molecular Formula:
- C22H30Cl2N2O2
- Molecular Weight:
- 425.3918
- MDL Number:
- MOL File:
- 126-12-5.mol
| Melting point | 280-287° (dec) |
|---|---|
| FDA UNII | 915Q054DLC |
SAFETY
Risk and Safety Statements
| RIDADR | 1544 |
|---|---|
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 2933330000 |
| Toxicity | mouse,LD50,intraperitoneal,80mg/kg (80mg/kg),Journal of Pharmacology and Experimental Therapeutics. Vol. 119, Pg. 26, 1957. |
ANILERIDINE HYDROCHLORIDE CII (250 MG) Chemical Properties,Uses,Production
Originator
Leritine HCl,Merck Sharp and Dohme,US,1958
Uses
Analgesic (narcotic).
Definition
ChEBI: Anileridine dihydrochloride is a hydrochloride salt prepared from anileridine and 2 equivalents of hydrogen chloride. It has a role as an opioid analgesic. It contains an anileridine(2+).
Manufacturing Process
A mixture of 7.8 grams (0.05 mol) of β-(p-aminophenyl)ethyl chloride
hydrochloride, 12.5 grams (0.025 mol) of 4-phenyl-4-carboethoxypiperidine
carbonate, 10.5 grams (0.125 mol) sodium bicarbonate, and 100 cc of
anhydrous ethanol are mixed, stirred and heated under reflux for a period of
approximately 40 hours and then concentrated in vacuum to dryness. The
residual material is triturated with 50 cc of water, decanted, washed by
decantation with an additional 50 cc of water, and then dried in vacuum to
give N-[β-(p-aminophenyl)ethyl]-4-phenyl-4-carboethoxypiperidine.
The N-[β-(p-aminophenyl)ethyl]-4-phenyl-4-carboethoxypiperidine is dissolved
in 50 cc of hot anhydrous ethanol, an excess (about 20 cc) of 20% alcoholic
hydrochloric acid solution is added; upon scratching the side of the container
crystals form. One hundred cubic centimeters of ether are then added to the
mixture, the ethereal mixture is cooled, and the crystalline material which
precipitates is recovered by filtration, washed with ether, and dried to give
12.7 grams of N-[β-(p-aminophenyl)ethyl]-4-phenyl-4-carboethoxypiperidine
dihydrochloride which can be further purified by recrystallization from ethanol
or methanal to give substantially pure material; MP 275-277°C.
brand name
Leritine (Merck).
Therapeutic Function
Narcotic analgesic