AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE
![AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE Structure](CAS/GIF/106566-58-9.gif)
- CAS No.
- 106566-58-9
- Chemical Name:
- AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE
- Synonyms
- AS 101;RT-011323;CTK8E8213;CTK8E8213;RT-011323;Interleukin Related;AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE;AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE;RPE,NFκB,AS 101,Caspase,Inhibitor,inhibit,AS-101,diseases,immunomodulatory,Ossirene,autoimmune,malignancies,tellurium,IL-6,IL-8,p65,Interleukin Related,STAT3,phosphorylation
- CBNumber:
- CB3838356
- Molecular Formula:
- C2H4Cl3O2Te.H4N
- Molecular Weight:
- 312.049
- MDL Number:
- MFCD01682758
- MOL File:
- 106566-58-9.mol
- MSDS File:
- SDS
| storage temp. | Inert atmosphere,Room Temperature |
|---|---|
| solubility | Soluble in DMSO |
| form | solid |
| color | White crystalline |
| FDA UNII | 708681952A |
AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21443 | AS-101 ≥95% | 106566-58-9 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 21443 | AS-101 ≥95% | 106566-58-9 | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 21443 | AS-101 ≥95% | 106566-58-9 | 10mg | $153 | 2024-03-01 | Buy |
| Tocris | 2446 | AS101 | 106566-58-9 | 50 | $616 | 2021-12-16 | Buy |
| Tocris | 2446 | AS101 | 106566-58-9 | 10 | $147 | 2021-12-16 | Buy |
AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE Chemical Properties,Uses,Production
Uses
AS 101 inhibits AKT activity in leukemic cells and has bee shown to favorably affect renal pathologies in various animal models. AS 101 inhibition of the AKT downstream pathway by AS101 has clinical potential in alleviating the progression of diabetic nephropathy.
Biological Activity
Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1 α , IL-2 and TNF- α release.
References
[1] kalechman y, sredni b, weinstein t, et al. production of the novel mesangial autocrine growth factors gdnf and il-10 is regulated by the immunomodulator as101[j]. journal of the american society of nephrology, 2003, 14(3): 620-630.
[2] kalechman y, gafter u, weinstein t, et al. inhibition of interleukin-10 by the immunomodulator as101 reduces mesangial cell proliferation in experimental mesangioproliferative glomerulonephritis association with dephosphorylation of stat3[j]. journal of biological chemistry, 2004, 279(23): 24724-24732.
[3] sredni b, caspi r r, klein a, et al. a new immunomodulating compound (as-101) with potential therapeutic application[j]. nature, 1987, 330(6144): 173-176.
[4] sredni b, albeck m, tichler t, et al. bone marrow-sparing and prevention of alopecia by as101 in non-small-cell lung cancer patients treated with carboplatin and etoposide[j]. journal of clinical oncology, 1995, 13(9): 2342-2353.
[5] kalechman y, gafter u, gal r, et al. anti-il-10 therapeutic strategy using the immunomodulator as101 in protecting mice from sepsis-induced death: dependence on timing of immunomodulating intervention[j]. the journal of immunology, 2002, 169(1): 384-392.
AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE Preparation Products And Raw materials
Raw materials
Preparation Products
AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50002 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66099280 17798518460 | cfzhang@aikonchem.com | China | 19918 | 55 |