platyphylline
- CAS No.
- 480-78-4
- Chemical Name:
- platyphylline
- Synonyms
- Platifillin;Platiphyllin;Platiphillin;Platyphyllin;platyphylline;Einecs 207-558-6;66641-38-1 (Hydrochloride);PLATYPHYLLINI HYDROTARTRAS;12-Hydroxy-1,2-dihydrosenecionan-11,16-dione;(1R)-1,2-Dihydro-12-hydroxysenecionan-11,16-dione
- CBNumber:
- CB3914285
- Molecular Formula:
- C18H27NO5
- Molecular Weight:
- 337.41
- MDL Number:
- MFCD01699075
- MOL File:
- 480-78-4.mol
- MSDS File:
- SDS
| Melting point | 129° |
|---|---|
| alpha | D20 -56.4° (c = 0.7 in chloroform) |
| Boiling point | 539.6±50.0 °C(Predicted) |
| Density | 1.22±0.1 g/cm3(Predicted) |
| pka | 12.83±0.40(Predicted) |
| EWG's Food Scores | 1 |
| FDA UNII | A91172AJBY |
platyphylline price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 059765 | 12-Hydroxy-1,2-dihydrosenecionan-11,16-dione | 480-78-4 | 500mg | $199 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0016155 | PLATYPHYLLINE 95.00% | 480-78-4 | 1G | $232.05 | 2021-12-16 | Buy |
| Matrix Scientific | 059765 | 12-Hydroxy-1,2-dihydrosenecionan-11,16-dione | 480-78-4 | 1g | $306 | 2021-12-16 | Buy |
| Matrix Scientific | 059765 | 12-Hydroxy-1,2-dihydrosenecionan-11,16-dione | 480-78-4 | 5g | $1071 | 2021-12-16 | Buy |
| Arctom | CFN00403 | Platyphylline ≥98% | 480-78-4 | 5mg | $468 | 2021-12-16 | Buy |
platyphylline Chemical Properties,Uses,Production
Description
A hepatotoxic alkaloid, the base has been isolated from Senecio adnatus D.C., S. hygrophilus Dyer & Sm. and S. piatyphyllus D.C. The alkaloid is only sparingly soluble in petroleum ether or hot H20, more so in Me2CO, EtOH, C6H6 or Et20 and readily soluble in CHCI3. It is laevorotatory with [α]D - 45.09° (CHCI3). The perchlorate occurs as colourless prisms from H20, m.p. 222-3°C (dec.); the picrolonate, dark yellow needles, m.p. 205-6°C (dec.); aurichloride, m.p. 200-loC (dec.) and the methiodide, m.p. 216-7°C; [α]D - 31.27° (EtOH). The alkaloid contains one hydroxyl group but no methoxyl or methylimino groups. On hydrolysis it furnishes platynecine, CSH1S0 2N, m.p. 148°C; [α]D - 56.8° (CHCI3) and platynecic acid, ClOH140 4 , m.p. l54-5°C which is identical with senecic acid lactone.
Uses
12-Hydroxy-1,2-dihydrosenecionan-11,16-dione is a pyrrolizidine alkaloid which can be found in various Senecio species. It can be useful in the generation and characterization of monoclonal antibodies against the pyrrolizidine alkaloid retrorsine .
Definition
ChEBI: Platyphylline is a macrolide.
References
Orekhov, Tiedebel., Ber., 68,653 (1935)
Orekhov, Konovalova, Tiedebel., ibid, 68, 1886 (1935)
Orekhov, Tiedebel., J. Gen. Chern. USSR, 8,273 (1938)
de Waal., Onderstepoort J., 15,251 (1940)
Koekemoer, Warren., J. Chern. Soc., 63 (1955)
platyphylline Preparation Products And Raw materials
Raw materials
Preparation Products
platyphylline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; | info@afinechem.com | China | 15377 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9020 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50002 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 15185 | 58 |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 7059 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55936 | 58 |
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