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SPIROXATRINE

SPIROXATRINE structure

CAS No.: 1054-88-2

Chemical Name:: SPIROXATRINE

Synonyms: R 5188;SPIROXATRINE;Spiroxatrine (R 5188);SPIROXATRINE (R 5188) SELECTIVE SEROTONI N 5;8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one;8-[(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4,5]DECAN-4-ONE;1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-;8-((2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one;(+/-)-8-[(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHYL]-1-PHENYL-1,3,8-TRIAZA-SPIRO[4,5]DECAN-4-ONE;R 5188, (±)-8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triaza-spiro[4,5]decan-4-one

CBNumber:: CB4157162

Molecular Formula:: C22H25N3O3

Molecular Weight:: 379.45

MDL Number:: MFCD00055134

MOL File:: 1054-88-2.mol

Last updated:2023-05-18 11:31:11

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SPIROXATRINE Properties

Melting point	215.8-218.0 °C
Boiling point	602.8±55.0 °C(Predicted)
Density	1.32±0.1 g/cm3(Predicted)
storage temp.	Store at RT
solubility	0.1 M HCl: moderately soluble
pka	15.03±0.20(Predicted)
form	powder
color	white
FDA UNII	DR0QR50ALL

SAFETY

Risk and Safety Statements

WGK Germany	3

SPIROXATRINE price More Price(8)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Tocris	0631	Spiroxatrine	1054-88-2	10	$145	2021-12-16	Buy
Tocris	0631	Spiroxatrine	1054-88-2	50	$593	2021-12-16	Buy
TRC	S683503	Spiroxatrine(R5188)	1054-88-2	10mg	$105	2021-12-16	Buy
Usbiological	466452	Spiroxatrine	1054-88-2	10mg	$382	2021-12-16	Buy
Usbiological	256729	Spiroxatrine	1054-88-2	10mg	$389	2021-12-16	Buy

Product number	Packaging	Price	Buy
0631	10	$145	Buy
0631	50	$593	Buy
S683503	10mg	$105	Buy
466452	10mg	$382	Buy
256729	10mg	$389	Buy

SPIROXATRINE Chemical Properties,Uses,Production

Uses

Spiroxatrine (R 5188) is a SR-1A antagonist.

Definition

ChEBI: 8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one is a member of imidazolidines.

Biological Activity

5-HT 1A antagonist. More active and selective than spiperone. Also a very potent α 2C adrenergic receptor antagonist.

SPIROXATRINE Preparation Products And Raw materials

Raw materials

Preparation Products

SPIROXATRINE Suppliers

Global( 41)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21149	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
BOC Sciences	--	info@bocsci.com	USA	0	65
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44894	58
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8618	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840	psaitong@jm-bio.com	China	29778	58

Supplier	Advantage
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
TargetMol Chemicals Inc.	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Aladdin Scientific	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
EMMX Biotechnology LLC	60
BOC Sciences	65
Energy Chemical	58
Changzhou Furuisi Biotechnology Co., Ltd	58
Beijing Jin Ming Biotechnology Co., Ltd.	58

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SPIROXATRINE R 5188 (+/-)-8-[(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHYL]-1-PHENYL-1,3,8-TRIAZA-SPIRO[4,5]DECAN-4-ONE 8-[(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4,5]DECAN-4-ONE SPIROXATRINE (R 5188) SELECTIVE SEROTONI N 5 R 5188, (±)-8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triaza-spiro[4,5]decan-4-one Spiroxatrine (R 5188) 8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one 1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl- 8-((2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one 1054-88-2 Serotonin receptor