Melanotan-1

Melanotan-1 Properties

Density	1.46±0.1 g/cm3(Predicted)
RTECS	OS1830200
storage temp.	−20°C
form	Solid
pka	4.43±0.10(Predicted)
Water Solubility	Soluble to 0.60 mg/ml in sterile water
Sequence	Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
InChIKey	UAHFGYDRQSXQEB-LEBBXHLNSA-N
CAS DataBase Reference	75921-69-6(CAS DataBase Reference)
FDA UNII	QW68W3J66U
NCI Drug Dictionary	afamelanotide
ATC code	D02BB02

SAFETY

Risk and Safety Statements

WGK Germany	3

Melanotan-1 price More Price(14)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	M8764	[Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt ≥95% (HPLC)	75921-69-6	1mg	$145.8	2024-03-01	Buy
Alfa Aesar	J66191	[Nle⁴, D-Phe⁷] alpha-Melanocyte Stimulating Hormone amide trifluoroacetate salt	75921-69-6	1mg	$161	2024-03-01	Buy
Tocris	3013	[Nle4,D-phe7]-alpha-MSH	75921-69-6	1	$184	2021-12-16	Buy
Usbiological	256004	[Nle4,D-Phe7]-α-MSH	75921-69-6	1mg	$432	2021-12-16	Buy
Biosynth Carbosynth	FM39599	Melanotan 1	75921-69-6	5mg	$456	2021-12-16	Buy

Product number	Packaging	Price	Buy
M8764	1mg	$145.8	Buy
J66191	1mg	$161	Buy
3013	1	$184	Buy
256004	1mg	$432	Buy
FM39599	5mg	$456	Buy

Melanotan-1 Chemical Properties,Uses,Production

Features

Afamelanotide is a potent, linear synthetic analog of the naturally occurring peptide hormone α-melanocyte-stimulating hormone (α-MSH).Modified to have a stronger binding affinity to melanocortin- 1 receptor (MC1R) and a smaller disassociation constant, afamelanotide has a longer half-life and subsequently exerts longer pharmacologic activity than its parent hormone.

Uses

Melanotan 1 is a highly potent melanotropin with extended biological activity and resistance to enzymatic degredation by serum enzymes. [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt has been used to detect its effect on O2 consumption and CO2 production in C57BL/6 mice. It is also used to determine its effect on leptin secretion in the primary cultures of differentiated adipocytes.

Definition

ChEBI: Afamelanotide is a polypeptide comprising of 13 amino acids which is an analogue of alpha-melanocyte stimulating hormone. It is approved as a dermatologic drug for the prevention of phototoxicity in adult patients with erythropoietic protoporphyria. It has a role as a dermatologic drug.

Origin

Melanotan 1, an alpha MSH analog (Nle4DPhe7-Melanocyte-Stimulating Hormone), is a potent melanocortin developed in the 1980s. Melanotan 2 is a shorter cyclic variant of Melanotan 1 produced in the 1990s. Melanotan 2 was found to increase skin pigmentation at lower cumulative doses than Melanotan 1. However, in clinical trials it was found to have more side effects including nausea somnolence and penile erections[1].

References

[1] Robert T Dorr. “Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers.” Archives of dermatology 140 7 (2004): 827–35.

General Description

[Nle4, D-Phe7]-α-melanocyte stimulating hormone is a potent analogue of α;-melanocyte-stimulating hormone (α -MSH). αMSH is a tridecapeptide, mostly produced by the cells in the brain, pituitary and in circulation.

Biochem/physiol Actions

[Nle4, D-Phe7]-α-melanocyte stimulating hormone is 100 times more potent than α-MSH in stimulating melanoma tyrosinase, which is a rate limiting enzyme in melanin biosynthesis and is 26 times as potent as α-MSH in S91adenylate cyclase assay. α –MSH has an essential role to play in melanin production in animals. It also regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases.

Side effects

The TGA has previously warned consumers against the use of Melanotan-I and Melanotan-II for tanning and weight loss. Side-effects include darkened skin, increased moles and freckles, nausea, vomiting, loss of appetite, flushing of the face, involuntary stretching and yawning, and spontaneous erections.

storage

Store at -20°C

Melanotan-1 Preparation Products And Raw materials

Raw materials

Preparation Products

Melanotan-1 Suppliers

Global( 244)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com	China	19949	58
Hebei Xinsheng New Material Technology Co., LTD.	+86-16632316109	xinshengkeji@xsmaterial.com	China	1100	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
zhuzhou dingcheng meihei comestic co.,ltd	+undefined18873369619	dingchengbusiness8@163.com	China	242	58
Hebei Xunou new energy Technology Co., LTD	+undefined17531957005	xunou8@hbxunou.com	China	36	58
Shanghai Chinqesen Biotechnology Co., Ltd.	+86-16628886292 +86-19521323435	sales2@qschem-pharma.com	China	46	58
Dorne Chemical Technology co. LTD	+86-13583358881 +86-18560316533	Ethan@dornechem.com	China	296	58
Shanghai Yunao International Trade Co., Ltd	+8617621705551	asdf@shanghaihg.cn	China	265	58
Wuhan senwayer century chemical Co.,Ltd	+undefined-27-86652399 +undefined13627115097	market02@senwayer.com	China	882	58
Henan Tengmao Chemical Technology Co. LTD	+8615238638457	salesvip2@hntmhg.com	China	415	58

Supplier	Advantage
ZHEJIANG JIUZHOU CHEM CO., LTD	58
Hebei Xinsheng New Material Technology Co., LTD.	58
BOC Sciences	58
zhuzhou dingcheng meihei comestic co.,ltd	58
Hebei Xunou new energy Technology Co., LTD	58
Shanghai Chinqesen Biotechnology Co., Ltd.	58
Dorne Chemical Technology co. LTD	58
Shanghai Yunao International Trade Co., Ltd	58
Wuhan senwayer century chemical Co.,Ltd	58
Henan Tengmao Chemical Technology Co. LTD	58

View Lastest Price from Melanotan-1 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-05-21	Melanotan 1 75921-69-6	US $1.00 / g	1g	99%	100kg	Dorne Chemical Technology co. LTD
2024-05-21	Melanotan 1 75921-69-6	US $30.00 / box	1box	98%	2000box	hebei hongtan Biotechnology Co., Ltd
2024-05-21	Melanotan 1(MT-1) 75921-69-6	US $0.00-0.00 / Box	1Box	99	50000KG/month	Shanghai Affida new material science and technology center

Melanotan 1
75921-69-6
US $1.00 / g
99%
Dorne Chemical Technology co. LTD

Melanotan 1
75921-69-6
US $30.00 / box
98%
hebei hongtan Biotechnology Co., Ltd

Melanotan 1(MT-1)
75921-69-6
US $0.00-0.00 / Box
99
Shanghai Affida new material science and technology center

75921-69-6(Melanotan-1 )Related Search:

D-Phenylalanine Diethylstilbestrol Melanotan Ⅱ Actate,MelanotanⅡAcetate,Melanotan-II(MT-II),Melanotan II acetate salt,Mt-Ii(Melanotan),Melanotan 2,Melanotan Ц,MELANOTAN II ALPHA-MSH Melanotan II）,MT-I (a MSH)

ALPHA-MSH Melanotan,alpha-MSH Melanotan II acetate AC-LYS-PRO-VAL-NH2 MELANOTAN II, MT-Ⅱ

Melanotan 1 [Nle4, D-Phe7]alfa-MSH, Melanotan I MELANOTAN II TRIFLUOROACETATE SALT Melanotan Ⅱ MelanotanⅠ(α-MSH)

Melanotan I acetate AC-SYS(NLE)EH(D-PHE)RWGKPVK(BIOTIN)-AMIDE

1of4

[NLE4,D-PHE]ALPHA-MELANOCYTE STIMULATING HORMONE (NLE4,D-PHE7)-ALPHA-MSH [Nle4,D-Phe7]α-MSH Ac-L-Ser-L-Tyr-L-Ser-L-Nle-L-Glu-L-His-D-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2 N-Ac-L-Ser-L-Tyr-L-Ser-L-Nle-L-Glu-L-His-D-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2 [Nle4,DPhe7] a-MSH, amide [Nle4,DPhe7] a-MSH, amide:Melanotan Ⅰ [Nle4, D-Phe7]-α-MSH, amide [Nle4]-α-MSH, amide (Nle4,D-Phe7)-α-MSH AfaMelanotide, NDP-MSH, Melanotan 1, CUV1647 (Nle4,D-Phe7)-a-MSH AfaMelanotide, NDP-MSH, Melanotan 1, CUV1647 NLE4, D-PHE7 .ALPHA.-MSH, NDP-MSH, MELANOTAN I Melanotan Ⅰ Acetate [Nle4, D-Phe7] α-MSH NDP-MSH Melanotan Ⅰ [Nle4,D-Phe7] α -MSH NDP-MSH Melanotan I alpha-melanotropin, [Nle3,D-Phe7], trifluoroacetate Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 acetate salt a-Melanotropin (swine),4-L-norleucine-7-D-phenylalanine- Afamelanotide acetate [NLE4, D-PHE7]-ALPHA-MSH, AMIDE [NLE4,D-PHE7]-ALPHA-MELANOCYTE-STIMULATING HORMONE [NLE4,DPHE7] ALPHA-MELANOCYTE STIMULATING HORMONE, AMIDE NDP-MSHAC-SER-TYR-SER-NLE-GLU-HIS-D-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH2 NDP-MSH Melanotan ① Acetate [NLE4, DPHE7] A-MSH, AMIDE; MELANOTAN Ⅰ Melanotan Ⅰ MELANOTAN I AC-SYS-NLE-EHFRWGKPV-NH2 AC-SER-TYR-SER-NLE-GLU-HIS-D-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH2 NLE-4-D-PHE-7-A-MELANOCYTE*STIMULATING H ORMONE [Nle4,D-Phe7]-MSHNDP-MSH [Nle4,D-Phe7] a-Melanocyte stimulating hormone,amide [nle4, d-phe7]-α-melanocyte stimulating hormone trifluoroacetate salt MSH, 4-Nle-7-Phe-alpha- Melanotan I Acetate MelanotanⅠ(α-MSH) 4-Nle-7-phe-alpha-msh 4-Norleucyl-7-phenylalanine-alpha-msh Melanotan-1 Melanotropin Melanotan II(10mg) /Mt-2 for Tanning Melanotan 2 CAS NO.75921-69-6 CAS NO.75921-69-6 Afamelanotide [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone (MSH), amide [Nle4, D-Phe7]-α-Melanocyte stimulating hormone trifluoroacetate salt, ≥95% (HPLC) N-Acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-a-glutamyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide α-Melanotropin (swine), 4-L-norleucine-7-D-phenylalanine- Melanotan-1 USP/EP/BP 4-L-norleucine-7-D-phenylalanine-α-Melanotropin (Nle4,D-Phe7)-α-MSH Melanotan 1 (MT1) acetate MT I （Melanotan-1） MT-I (Melanotan I) Melanotan I (MT1) acetate [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt Melanotan I (Afamelanotide CUV1647) α-Melanotropin (swine), 4-L-norleucine-7-D-phenylalanine-