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5-Hydroxy-3,4-dihydroquinolin-2(1H)-one

5-Hydroxy-3,4-dihydroquinolin-2(1H)-one structure

CAS No.: 30389-33-4

Chemical Name:: 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one

Synonyms: 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one;5-Hydroxy-3,4-dihydrocarbostyryl;Carteolol EP Impurity B;5-HYDROXY-3;Carteolol int;Carteolol Impurity 2;Carteolol Intermediate;Aripiprazole impurity 7;Aripiprazole Impurity 14;Brexpiprazole Impurity 70

CBNumber:: CB4259600

Molecular Formula:: C9H9NO2

Molecular Weight:: 163.17

MDL Number:: MFCD01862194

MOL File:: 30389-33-4.mol

Last updated:2024-03-05 14:28:28

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5-Hydroxy-3,4-dihydroquinolin-2(1H)-one Properties

Melting point	225-227°C
Boiling point	381.2±42.0 °C(Predicted)
Density	1.282±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	9.63±0.20(Predicted)
color	White to Off-White
CAS DataBase Reference	30389-33-4(CAS DataBase Reference)
FDA UNII	BH76UU379C

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332-H315-H319-H335
Precautionary statements	P271-P260-P280
Hazard Codes	Xi
HS Code	2933499090

5-Hydroxy-3,4-dihydroquinolin-2(1H)-one price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D5669	3,4-Dihydro-5-hydroxy-1H-quinolin-2-one	30389-33-4	1G	$56	2024-03-01	Buy
TCI Chemical	D5669	3,4-Dihydro-5-hydroxy-1H-quinolin-2-one	30389-33-4	5G	$278	2024-03-01	Buy
TRC	H941410	5-Hydroxy-3,4-dihydro-2(1H)-quinolinone	30389-33-4	5g	$425	2021-12-16	Buy
SynQuest Laboratories	4H20-1-17	3,4-Dihydro-5-hydroxy-1H-quinolin-2-one	30389-33-4	250mg	$133	2021-12-16	Buy
Ark Pharm	P000281586	5-Hydroxy-3,4-dihydroquinolin-2(1H)-one 97%	30389-33-4	25g	$390	2021-12-16	Buy

Product number	Packaging	Price	Buy
D5669	1G	$56	Buy
D5669	5G	$278	Buy
H941410	5g	$425	Buy
4H20-1-17	250mg	$133	Buy
P000281586	25g	$390	Buy

5-Hydroxy-3,4-dihydroquinolin-2(1H)-one Chemical Properties,Uses,Production

Chemical Properties

Off-white Solid

Uses

Carteolol (C184450) metabolite.

Definition

ChEBI: 5-hydroxy-3,4-dihydro-2(1h)-quinolinone is a quinolone and a hydroxyquinoline.

Synthesis

To a 100 ml three-necked flask were added 3,4,7,8-tetrahydro-2,5 (1 H, 6Η) -quinoline dione (0.02 mol) and cyclohexane (25 ml). After stirring to dissolve in the ice bath for 10min, slowly add a dropwise N-bromosuccinimide (0.03mol) in cyclohexane (5ml), and reflux for 3h at the end of the dropwise addition. After completion of the reaction by TLC, cool down to room temperature. Water was added (the amount was 0.7 times the volume of the reactant), and the mixture was allowed to stand with stirring. The aqueous layer was extracted with ethyl acetate (1 × the volume of the aqueous layer 4 times), and the organic layers were combined. Anhydrous sulfuric acid Calcium was dried and filtered, the filtrate was evaporated to remove the solvent, and the residue was dried to give an off-white solid as a 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one (Yield 92.7percent).

5-Hydroxy-3,4-dihydroquinolin-2(1H)-one synthesis

Synthesis of 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one from 4,6,7,8-TETRAHYDRO-1H,3H-QUINOLINE-2,5-DIONE

5-Hydroxy-3,4-dihydroquinolin-2(1H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

5-HYDROXY-2(1H)-QUINOLINONE

5-Hydroxy-3,4-dihydroquinolin-2(1H)-one Suppliers

Global( 208)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
HangZhou RunYan Pharma Technology Co.,LTD.	+86-88660901 +86-18112526015	sales@runyanpharma.com	China	326	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15957	58
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9341	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2966	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58

Supplier	Advantage
HangZhou RunYan Pharma Technology Co.,LTD.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Hangzhou FandaChem Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Jinan Finer Chemical Co., Ltd	58
Accela ChemBio Inc.	58
Hubei xin bonus chemical co. LTD	58

View Lastest Price from 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-05-10	5-HYDROXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE 30389-33-4	US $65.00-650.00 / KG	1KG	0.99	20 tons	Zibo Hangyu Biotechnology Development Co., Ltd
2023-03-13	5-Hydroxy-3,4-dihydroquinolin-2(1H)-one 30389-33-4	US $0.00 / kg	1kg	99% HPLC	1000kg	HangZhou RunYan Pharma Technology Co.,LTD.
2020-04-25	5-HYDROXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE 30389-33-4	US $0.10 / KG	1KG	99.0%	1000 tons	Shaanxi Dideu Medichem Co. Ltd

5-HYDROXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE
30389-33-4
US $65.00-650.00 / KG
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

5-Hydroxy-3,4-dihydroquinolin-2(1H)-one
30389-33-4
US $0.00 / kg
99% HPLC
HangZhou RunYan Pharma Technology Co.,LTD.

5-HYDROXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE
30389-33-4
US $0.10 / KG
99.0%
Shaanxi Dideu Medichem Co. Ltd

30389-33-4(5-Hydroxy-3,4-dihydroquinolin-2(1H)-one)Related Search:

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1of4

3,4-DIHYDRO-5-HYDROXY-2(1H)-QUINOLINONE 5-HYDROXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE 5-HYDROXY-3,4-DIHYDRO-2(1H)-QUINOLINONE 3,4-Dihydro-5-hydroxycarbostyril 5-HYDROXY-3,4-DIHYDRO-2-QUINOLINE 5-Hydroxy-2(1H)-3,4-dihydroquinolinone 3,4-Dihydro-5-hydroxy-1H-quinolin-2-one 5-Hydroxy-3,4-dihydrocarbostyril 3,4-Dihydro-5-hydroxyquinolin-2(1H)-one 5-Hydroxy-1,2,3,4-tetrahydroquinoline-2-one 5-hydroxy-1,2,3,4-tetrahydro-2-quinolinone 5-hydroxy-1,2,3,4-tetrahydroquinolin-2-one 2(1H)-Quinolinone, 3,4-dihydro-5-hydroxy- Carteolol HCl EP Impurity B Carbostyril,3,4-dihydro-5-hydroxy- (8CI) Aripiprazole Impurity 14 Carteolol Intermediate 5-Hydroxy-3,4-dihydroquinolin-2(1H) Carteolol Impurity 2 Aripiprazole impurities1768 5-hydroxy-3,4-dihydro-1-h-quinoline 5-HYDROXY-3 4-DIHYDRO-1H-QUINOLIN-2-ONE 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one(For export only) 5-Hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline Carteolol Hydrochloride impurity B Aripiprazole impurity 7 Brexpiprazole Impurity 70 Carteolol int 5-Hydroxy-3,4-dihydrocarbostyryl 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one Carteolol EP Impurity B Carteolol EP Impurity B（Aripiprazole Impurity 26） 5-Hydroxy-3,4-dihydro-2(1H)-quinolinone (5-HQ) 5-Hydroxy-3,4-dihydro-2(1h)- quinolinone, 98% (Custom work) 30389-33-4 pharmacetical Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals API