BETA-ACETYLDIGOXIN
- CAS No.
- 5355-48-6
- Chemical Name:
- BETA-ACETYLDIGOXIN
- Synonyms
- Digotab;digoridb;Cardioreg;novodigal;Cor-puren;B-ACETYLDIGOXIN;β-Acetyl Digoxin;2-Acetyl Digoxin;16’-acetyldigoxin;ACETYLDIGOXIN, B-
- CBNumber:
- CB4328012
- Molecular Formula:
- C43H66O15
- Molecular Weight:
- 822.98
- MDL Number:
- MFCD00242932
- MOL File:
- 5355-48-6.mol
- MSDS File:
- SDS
| Melting point | 271-273°C |
|---|---|
| alpha | D20 +30.4° (c = 1.2 in alc) |
| Boiling point | 681.03°C (rough estimate) |
| Density | 1.1139 (rough estimate) |
| refractive index | 1.5940 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | Practically insoluble in water, sparingly soluble in methylene chloride, slightly soluble in ethanol (96 per cent). |
| pka | 13.41±0.70(Predicted) |
| FDA UNII | P7K44M64CW |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300+H330 |
| Precautionary statements | P260-P301+P330+P331+P310-P304+P340+P310-P403+P233 |
| RIDADR | 3249 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
BETA-ACETYLDIGOXIN price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0000642 | β-Acetyldigoxin for peak identification European Pharmacopoeia (EP) Reference Standard | 5355-48-6 | y0000642 | $150 | 2024-03-01 | Buy |
| Sigma-Aldrich | Y0000565 | β-Acetyldigoxin European Pharmacopoeia (EP) Reference Standard | 5355-48-6 | y0000565 | $220 | 2024-03-01 | Buy |
| Usbiological | 296661 | b-Acetyl digoxin | 5355-48-6 | 1mg | $595 | 2021-12-16 | Buy |
| TRC | A173665 | β-AcetylDigoxin | 5355-48-6 | 5mg | $1005 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | SHG0000423 | BETA-ACETYL DIGOXIN 95.00% | 5355-48-6 | 10MG | $1963.5 | 2021-12-16 | Buy |
BETA-ACETYLDIGOXIN Chemical Properties,Uses,Production
Chemical Properties
White Solid
Originator
Novodigal ,Asta Medica Arzneimittel
Uses
Digoxin derivative, a cardiotonic glycosides
Definition
ChEBI: Acetyldigoxin is a cardenolide glycoside.
Manufacturing Process
Dried crude product of the partial acetylation of digoxin (42 g) prepared from
digitalis - is dissolved under reflux in acetone (480 ml) and n-hexane (2400
ml) is added to the solution with stirring. Fine crystals, which begin to
separate immediately, are left at room temperature for 5 hours, then they are
filtered with suction, washed with n-hexane and dried in vacuum at 40°C,
yielding 32 g of crude β-acetyldigoxin (product 1). Product 1 (31 g) is
dissolved under reflux in chloroform (500 ml) and toluene (2500 ml) is added
thereto with stirring. The crystals, which separate after standing for 6 hours at
room temperature, are filtered, washed with toluene and ether and dried in
vacuum yielding 29 g of β-acetyldigoxin (product 2). MP: 249°-251°C.
The filtrate, which results from the separation of product 1, is evaparated to
dryness in vacuum. The residue, which mainly contains unreacted digoxin, is
purified by recrystallization from pyridine/ether/water (3.5:5:40) and
repeatedly acetylated. It can then be recycled to produce more β-
acetyldigoxin. The filtrate resulting from the separation of product 2 is
evaporated to dryness. The resulting residue contains the di- and polyacetyl
derivatives of digoxin, which are deacetylated to digoxin in a known manner and later is returned to a further acetylation process and can then be recycled
to produce more β-acetyldigoxin.
Beta-Acetyldigoxin may be prepared from digoxin, acetic acid and
dicyclohexylcarbodiimide using the last one as a condensing agent.
Therapeutic Function
Cardiotonic
BETA-ACETYLDIGOXIN Preparation Products And Raw materials
BETA-ACETYLDIGOXIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28149 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; | info@afinechem.com | China | 15377 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50002 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-83725681-603 | China | 4505 | 50 |
View Lastest Price from BETA-ACETYLDIGOXIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-09-08 | BETA-ACETYLDIGOXIN
5355-48-6
|
US $0.00-0.00 / KG | 1KG | 98% | 1tone | Henan Aochuang Chemical Co.,Ltd. |
-
- BETA-ACETYLDIGOXIN
5355-48-6
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.