ChemicalBook >> CAS DataBase List >>6-(Bromomethyl)-2,4-pteridinediamine hydrobromide
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide
- CAS No.
- 52853-40-4
- Chemical Name:
- 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide
- Synonyms
- 6-(Bromomethyl)-2,4-diaminopteridine Hydrobromide;2,4-pteridinediaMine, 6-(broMoMethyl)-, hydrobroMide;Nsc253943;Methotrexate Impurity 15;Methotrexate Impurity 16;Methotrexate Impurity 17 HBr;6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR;2, 4-diaMino-6-(broMoMethyl)-pteridine HCL;6-Bromomethyl-pteridine-2,4-diamine hydrobromide;2,4-Diamino-6-(bromomethyl)pteridine Hydrobromide
- CBNumber:
- CB51010881
- Molecular Formula:
- C7H8Br2N6
- Molecular Weight:
- 335.99
- MDL Number:
- MFCD09833976
- MOL File:
- 52853-40-4.mol
Last updated:2023-09-14 17:34:31
| Melting point | >195°C (dec.) |
|---|---|
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Light Brown to Brown |
| InChI | InChI=1S/C7H7BrN6.BrH/c8-1-3-2-11-6-4(12-3)5(9)13-7(10)14-6;/h2H,1H2,(H4,9,10,11,13,14);1H |
| InChIKey | KMQIBGKVZDBGAH-UHFFFAOYSA-N |
| SMILES | NC1=NC(N)=NC2=NC=C(CBr)N=C12.Br |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B685475 | 6-(Bromomethyl)-2,4-pteridinediamineHydrobromide(TechnicalGrade) | 52853-40-4 | 5g | $155 | 2021-12-16 | Buy |
| AK Scientific | Z3606 | 6-Bromomethyl-pteridine-2,4-diamineHBr | 52853-40-4 | 10g | $200 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB19250 | 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide (technical grade) | 52853-40-4 | 50g | $250 | 2021-12-16 | Buy |
| Matrix Scientific | 093056 | 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide tech. | 52853-40-4 | 250mg | $21 | 2021-12-16 | Buy |
| Matrix Scientific | 093056 | 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide tech. | 52853-40-4 | 50050g | $33 | 2021-12-16 | Buy |
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Chemical Properties,Uses,Production
Description
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide is a potent inhibitor of the enzyme nitroaldolase (EC 1.2.1.22) and has been shown to inhibit cell growth in murine leukemia cells. This reaction is mediated by the addition of bromide to isobutyl esters, leading to a benzyl ester intermediate which undergoes an electrophilic attack on nitroaldolase. The mechanism of action for this drug involves the inhibition of membrane transport and chloride ion influx, which are necessary for the proliferation of tumor cells. 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide also inhibits DNA synthesis through its effects on thymidylate synthase, preventing nucleotide production from thymine and dihydrofolate reductase activity.
Chemical Properties
Light Brown Solid
Uses
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide can be used as organic synthesis intermediate and pharmaceutical intermediate.
Application
6-(Bromomethyl)-2,4-pteridinediamine Hydrobromide (Technical Grade) is a useful research chemical used in the preparation of novel methotrexate derivatives as antirheumatic agents as well as the preparation of pteridine reductase inhibitors.
Synthesis of 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide from 2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
Global( 156)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15957 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8615821988213 | info@longyupharma.com | China | 2531 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1320 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
View Lastest Price from 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-09-29 | 6-(Bromomethyl)-2,4-pteridinediamine Hydrobromide
52853-40-4
|
US $0.00-0.00 / Kg/Drum | 1KG | 90%min | 100KGS | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2019-07-06 | 6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR
52853-40-4
|
US $1.00 / KG | 1KG | 98% | 1tons | Career Henan Chemical Co |
-
- 6-(Bromomethyl)-2,4-pteridinediamine Hydrobromide
52853-40-4
- US $0.00-0.00 / Kg/Drum
- 90%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR
52853-40-4
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
52853-40-4(6-(Bromomethyl)-2,4-pteridinediamine hydrobromide)Related Search:
2, 4-diaMino-6-(broMoMethyl)-pteridine HCL
2,4-diamino-6-(bromomethyl)pteridine(for methotrexate)
6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR
2,4-Diamino-6-(bromomethyl)pteridine Hydrobromide
2,4-PteridinediaMine, 6-(broMoMethyl)-, MonohydrobroMide
6-(BroMoMethyl)-2,4-pteridinediaMine HydrobroMide (Technical Grade)
Nsc253943
6-Bromomethyl-pteridine-2,4-diamine hydrobromide
2,4-PteridinediaMine, 6-(broMoMethyl)-, hydrobroMide (1:1)
6-(Bromomethyl)-2,4-pteridinediamine hydrochloride
6-(Bromomethyl)pteridine-2,4-diamine hydrobromide (1:1)
Methotrexate Impurity 15
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide, tech grade
Methotrexate Impurity 16
6-Bromomethyl-pteridine-2,4-diamine hbrQ: What is
6-Bromomethyl-pteridine-2,4-diamine hbr Q: What is the CAS Number of
6-Bromomethyl-pteridine-2,4-diamine hbr Q: What is the storage condition of
6-Bromomethyl-pteridine-2,4-diamine hbr Q: What are the applications of
6-Bromomethyl-pteridine-2,4-diamine hbr
2,4-pteridinediaMine, 6-(broMoMethyl)-, hydrobroMide
6-(Bromomethyl)-2,4-diaminopteridine Hydrobromide
Methotrexate Impurity 17 HBr
6-(bromomethyl)-2,4-Pteridinediamine hydrobromide (1:1)
52853-40-4
C7H72N6HBr
C7H8Br2N6
BrHC7H7BrN6
C7H7BrN6BrH
Aromatics
Bases & Related Reagents
Inhibitors
Nucleotides
Aromatics Compounds