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Flumexadol

CAS No.
30914-89-7
Chemical Name:
Flumexadol
Synonyms
1841CERM;CERM-1841;Flumexadol;2-(α,α,α-Trifluoro-m-tolyl)morpholine;2-[3-(Trifluoromethyl)phenyl]morpholine;Morpholine, 2-[3-(trifluoromethyl)phenyl]-
CBNumber:
CB51178778
Molecular Formula:
C11H12F3NO
Molecular Weight:
231.21
MDL Number:
MOL File:
30914-89-7.mol
MSDS File:
SDS
Last updated:2024-07-02 08:55:09

Flumexadol Properties

Boiling point 132 °C(Press: 10 Torr)
Density 1.2081 (estimate)
storage temp. Store at -20°C
solubility DMSO: 100 mg/mL (432.51 mM)
pka 8.41±0.40(Predicted)
form Liquid
color Colorless to light yellow
FDA UNII V9783UEL0F

Flumexadol price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC T900660 2-[3-(Trifluoromethyl)phenyl]morpholine 30914-89-7 10mg $45 2021-12-16 Buy
ChemScene CS-0109485 Flumexadol 98.87% 30914-89-7 10mg $115 2021-12-16 Buy
American Custom Chemicals Corporation HCH0126047 2-[3-(TRIFLUOROMETHYL)PHENYL]-MORPHOLINE 95.00% 30914-89-7 1G $787.5 2021-12-16 Buy
American Custom Chemicals Corporation HCH0126047 2-[3-(TRIFLUOROMETHYL)PHENYL]-MORPHOLINE 95.00% 30914-89-7 2.5G $1663.02 2021-12-16 Buy
American Custom Chemicals Corporation HCH0126047 2-[3-(TRIFLUOROMETHYL)PHENYL]-MORPHOLINE 95.00% 30914-89-7 5G $2223.51 2021-12-16 Buy
Product number Packaging Price Buy
T900660 10mg $45 Buy
CS-0109485 10mg $115 Buy
HCH0126047 1G $787.5 Buy
HCH0126047 2.5G $1663.02 Buy
HCH0126047 5G $2223.51 Buy

Flumexadol Chemical Properties,Uses,Production

Biological Activity

Flumexadol is an orally active non-narcotic analgesic. It is a selective and affinity agonist of the 5-HT2C receptor with a Ki of 25 nM for the (+)-enantiomer of Flumexadol, 40-fold more selective than the 5-HT2A receptor.

in vivo

In rats and dogs dosed with 14 C-Flumexadol (CERM1841), the 14 C is excreted in the urine. The 14 C eliminated in the faeces of dog is significantly higher than for rat. Conjugated metabolites, mostly glucuronides, accounted for the greater part of the urinary radioactivity in both species. Biotransformation products are predominantly acids in both species, follows by significant amounts of basic metabolites, with very little neutral substances. The major urinary metabolite in rats is 3-trifluoromethylbenzoic acid and 3-trifluoromethylhipuric acid. In the dog it is 3-trifluoromethylmandelic acid in addition to the benzoic acid and its conjugate. The basic products identified in the urine of both species are unchanged drug and 1-amino-2-hydroxy-2-(3-trifluoromethylphenyl)ethane, with the first predominating.

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target

5-HT 2C Receptor

25 nM (Ki)

Flumexadol Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 20)Suppliers
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Hubei Jusheng Technology Co.,Ltd.
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TargetMol Chemicals Inc.
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Career Henan Chemica Co
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Aladdin Scientific
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Jiangsu yize medical technology co. LTD 18550739526 23903480@qq.com China 5840 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5132 58
Block Chemical Technology (Shanghai) Co., LTD 021-20432219 13918097649 li_jinfei@acblock-lab.com China 9964 58
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Flumexadol 1841CERM 2-(α,α,α-Trifluoro-m-tolyl)morpholine 2-[3-(Trifluoromethyl)phenyl]morpholine CERM-1841 Morpholine, 2-[3-(trifluoromethyl)phenyl]- 30914-89-7