ChemicalBook >> CAS DataBase List >>Z-FL-COCHO
Z-FL-COCHO
- CAS No.
- 1373215-15-6
- Chemical Name:
- Z-FL-COCHO
- Synonyms
- Z-FL-COCHO;LY 3000328;CATHEPSIN S INHIBITOR;LY3000328，Cathepsin S inhibitor;CATHEPSIN S INHIBITOR ;LY-3000328;LY3000328;Cathepsin,LY3000328,LY 3000328,Inhibitor,LY-3000328,inhibit;(3R,4S)-4-(4-fluorobenzamido)-6-(4-(oxetan-3-yl)piperazin-1-yl)chroman-3-yl methylcarbamate;((3R,4S)-4-((4-FLUOROBENZOYL)AMINO)-6-(4-(OXETAN-3-YL)PIPERAZIN-1-YL)CHROMAN-3-YL)N-METHYLCARBAMATE;N-[(3R,4S)-3,4-Dihydro-3-[[(methylamino)carbonyl]oxy]-6-[4-(3-oxetanyl)-1-piperazinyl]-2H-1-benzopyran-4-yl]-4-fluorobenzamide;Benzamide, N-[(3R,4S)-3,4-dihydro-3-[[(methylamino)carbonyl]oxy]-6-[4-(3-oxetanyl)-1-piperazinyl]-2H-1-benzopyran-4-yl]-4-fluoro-
- CBNumber:
- CB5175767
- Molecular Formula:
- C25H29FN4O5
- Molecular Weight:
- 484.52
- MDL Number:
- MFCD04974155
- MOL File:
- Mol file
- MSDS File:
- SDS
Last updated:2023-09-20 16:43:00
| Boiling point | 701.6±60.0 °C(Predicted) |
|---|---|
| Density | 1.38±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≥24.25 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| form | Powder |
| pka | 12.50±0.46(Predicted) |
| FDA UNII | 1210T8CX6K |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| HS Code | 2934999090 | |||||||||
| NFPA 704 |
|
Z-FL-COCHO price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29729 | LY3000328 | 1373215-15-6 | 500μg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 29729 | LY3000328 | 1373215-15-6 | 10mg | $632 | 2024-03-01 | Buy |
| Cayman Chemical | 29729 | LY3000328 | 1373215-15-6 | 1mg | $152 | 2024-03-01 | Buy |
| Cayman Chemical | 29729 | LY3000328 | 1373215-15-6 | 5mg | $356 | 2024-03-01 | Buy |
| TRC | L468955 | LY3000328 | 1373215-15-6 | 2.5mg | $525 | 2021-12-16 | Buy |
Z-FL-COCHO Chemical Properties,Uses,Production
Description
LY3000328 is a potent cathepsin S inhibitor (IC50 = 7.7 nM for the human enzyme). It is selective for cathepsin S over cathepsin L, K, B, and V (IC50s = >10,000, >10,000, 4,390, and 21,500 nM, respectively). LY3000328 (1-30 mg/kg) reduces aortic diameter in a mouse model of calcium chloride-induced abdominal aortic aneurysm.
Uses
LY 3000328 is a cathepsin S inhibitor for treatment of abdominal aortic aneurysm. Further provides methods for treating plaque instability, atherosclerosis, or autoimmune disorders such as rheumatoid arthritis, psoriasis, and lupus comprising administering a therapeutically effective amount of a disclosed compound.
target
cathepsin S
References
[1] wiener jj, sun s, thurmond rl. recent advances in the design of cathepsin s inhibitors. curr top med chem. 2010;10(7):717-32.
[2] lee-dutra a, wiener dk, sun s. cathepsin s inhibitors: 2004-2010. expert opin ther pat. 2011;21(3):311-37.
Z-FL-COCHO Preparation Products And Raw materials
Raw materials
Preparation Products
Z-FL-COCHO Suppliers
Global( 57)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9333 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| EnliPharma Technology Co., Ltd | 0551-66399836 18955197623 | sales@enlipharma.com | China | 1874 | 55 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3423 | 58 |
View Lastest Price from Z-FL-COCHO manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | Cathepsin S inhibitor
1373215-15-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Cathepsin S inhibitor
1373215-15-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Cathepsin S inhibitor
1373215-15-6
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Cathepsin S inhibitor
1373215-15-6
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
Z-FL-COCHO
((3R,4S)-4-((4-FLUOROBENZOYL)AMINO)-6-(4-(OXETAN-3-YL)PIPERAZIN-1-YL)CHROMAN-3-YL)N-METHYLCARBAMATE
CATHEPSIN S INHIBITOR
N-[(3R,4S)-3,4-Dihydro-3-[[(methylamino)carbonyl]oxy]-6-[4-(3-oxetanyl)-1-piperazinyl]-2H-1-benzopyran-4-yl]-4-fluorobenzamide
LY 3000328
Benzamide, N-[(3R,4S)-3,4-dihydro-3-[[(methylamino)carbonyl]oxy]-6-[4-(3-oxetanyl)-1-piperazinyl]-2H-1-benzopyran-4-yl]-4-fluoro-
(3R,4S)-4-(4-fluorobenzamido)-6-(4-(oxetan-3-yl)piperazin-1-yl)chroman-3-yl methylcarbamate
CATHEPSIN S INHIBITOR ;LY-3000328;LY3000328
LY3000328，Cathepsin S inhibitor
Cathepsin,LY3000328,LY 3000328,Inhibitor,LY-3000328,inhibit
1373215-15-6
C25H29FN4O5