ChemicalBook >> CAS DataBase List >>MK-4827 (tosylate)
MK-4827 (tosylate)
- CAS No.
- 1038915-73-9
- Chemical Name:
- MK-4827 (tosylate)
- Synonyms
- Niraparib Tosylate;Niraparib TOS;Niraparib TsOH;MK-4827 (tosylate);Niraparib Tosilate;Niraparib(MK-4827) tosylate;MK-4827(Niraparib) tosylate;niraparib p-toluenesulfonate;MK-4827, Niraparib TsOH salt;Niraparib Tosylate (MK-4827)
- CBNumber:
- CB52682012
- Molecular Formula:
- C26H28N4O4S
- Molecular Weight:
- 492.58992
- MDL Number:
- MFCD28167748
- MOL File:
- 1038915-73-9.mol
Last updated:2024-05-18 08:51:57
| Melting point | >142oC (dec.) |
|---|---|
| storage temp. | -20°C Freezer |
| solubility | Methanol (Slightly) |
| form | Solid |
| color | Off-White to Pale Yellow |
| InChIKey | LCPFHXWLJMNKNC-XOIICWPPNA-N |
| SMILES | S(C1C=CC(C)=CC=1)(O)(=O)=O.C(C1=CC=CC2=CN(C3C=CC([C@H]4CNCCC4)=CC=3)N=C12)(=O)N |&1:23,r| |
| FDA UNII | 75KE12AY9U |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
MK-4827 (tosylate) price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20842 | MK-4827 (tosylate) ≥98% | 1038915-73-9 | 5mg | $46 | 2024-03-01 | Buy |
| Cayman Chemical | 20842 | MK-4827 (tosylate) ≥98% | 1038915-73-9 | 50 mg | $253 | 2024-03-01 | Buy |
| Cayman Chemical | 20842 | MK-4827 (tosylate) ≥98% | 1038915-73-9 | 1mg | $32 | 2023-01-06 | Buy |
| Cayman Chemical | 20842 | MK-4827 (tosylate) ≥98% | 1038915-73-9 | 10mg | $83 | 2024-03-01 | Buy |
| Cayman Chemical | 20842 | MK-4827 (tosylate) ≥98% | 1038915-73-9 | 25mg | $149 | 2024-03-01 | Buy |
MK-4827 (tosylate) Chemical Properties,Uses,Production
Description
Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively; with significant activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP, and Tank1. Niraparib tosylate leads to inhibition of repair of DNA damage, activates apoptosis, and shows anti-tumor activity.
Uses
Niraparib is a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.
in vitro
In a whole-cell assay, Niraparib (MK-4827) tosylate hydrate inhibits PARP activity with EC50=4 nM and EC90=45 nM. Niraparib tosylate hydrate inhibits the proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10-100 nM range. Niraparib tosylate hydrate displays excellent PARP 1 and 2 inhibition with IC50=3.8 and 2.1 nM, respectively, and in a whole-cell assay. Niraparib tosylate hydrate inhibits PARP within 15 minutes of treatment, reaching about 85% inhibition in the A549 cells at 1 h and about 55% inhibition at 1 h for the H1299 cells.
MK-4827 (tosylate) Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 136)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Hope Pharmaceutical Co., Ltd. | +86-010-67886402 +8613611125266 | market@hopelife.cn | China | 71 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 952 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 | sales@tianpharm.com | CHINA | 304 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Beijing Yibai Biotechnology Co., Ltd | 0086-182-6772-3597 | sales04@yibaibiotech.com | CHINA | 419 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| WinWin Chemical CO., Limited | +86-0577-64498589 +8615325081899 | sales@win-winchemical.com | China | 14145 | 58 |
Related articles
- MK-4827 (tosylate)
- To validate that MK-4827 (Niraparib) inhibits PARP in these cell lines, A549 and H1299 cells are treated with 1 μM MK-4827 for....
- Aug 26，2019
View Lastest Price from MK-4827 (tosylate) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-05-27 | MK-4827 (tosylate)
1038915-73-9
|
US $20.00 / kg | 1kg | 98% | 2000kg | hebei hongtan Biotechnology Co., Ltd | |
 |
2024-05-10 | MK-4827 (tosylate)
1038915-73-9
|
US $0.10-0.30 / kg | 1kg | 99% | 20n tons | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2022-09-23 | Niraparib tosylate
2191-20-5
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- MK-4827 (tosylate)
1038915-73-9
- US $20.00 / kg
- 98%
- hebei hongtan Biotechnology Co., Ltd
-
- MK-4827 (tosylate)
1038915-73-9
- US $0.10-0.30 / kg
- 99%
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- Niraparib tosylate
2191-20-5
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
1038915-73-9(MK-4827 (tosylate))Related Search:
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1038915-73-9
C19H20N4OC7H8O3S