6-ForMylindolo[3,2-b]carbazole
![6-ForMylindolo[3,2-b]carbazole Structure](CAS/GIF/172922-91-7.gif)
- CAS No.
- 172922-91-7
- Chemical Name:
- 6-ForMylindolo[3,2-b]carbazole
- Synonyms
- FICZ;6-FORMYLINDOLO A CARBAZOLE;6-FORMYLINDOLO [3,2-B] CARBAZOLE;6-Formylindolo[3,2-b]carbazole (FICZ);Indolo[3,2-b]carbazole-6-carbaldehyde;5H,11H-indolo[3,2-b]carbazole-6-carbaldehyde;5,11-dihydroindolo[3,2-b]carbazole-6-carbaldehyde;5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde;inhibit,Inhibitor,Aryl Hydrocarbon Receptor,AhR,FICZ;Indolo[3,2-b]carbazole-6-carboxaldehyde, 5,11-dihydro-
- CBNumber:
- CB5312397
- Molecular Formula:
- C19H12N2O
- Molecular Weight:
- 284.31
- MDL Number:
- MFCD09879259
- MOL File:
- 172922-91-7.mol
- MSDS File:
- SDS
| Boiling point | 630.3±35.0 °C(Predicted) |
|---|---|
| Density | 1.463±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 10 mg/ml). |
| pka | 15.66±0.30(Predicted) |
| form | powder |
| color | yellow to orange |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| WGK Germany | 1 | |||||||||
| NFPA 704 |
|
6-ForMylindolo[3,2-b]carbazole price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1489 | FICZ ≥95% (HPLC) | 172922-91-7 | 1MG | $131 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1489 | FICZ ≥95% (HPLC) | 172922-91-7 | 5MG | $530 | 2023-06-20 | Buy |
| Cayman Chemical | 19529 | 6-Formylindolo[3,2-b]carbazole ≥95% | 172922-91-7 | 500μg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 19529 | 6-Formylindolo[3,2-b]carbazole ≥95% | 172922-91-7 | 1mg | $115 | 2024-03-01 | Buy |
| Cayman Chemical | 19529 | 6-Formylindolo[3,2-b]carbazole ≥95% | 172922-91-7 | 5mg | $448 | 2024-03-01 | Buy |
6-ForMylindolo[3,2-b]carbazole Chemical Properties,Uses,Production
Description
6-Formylindolo(3,2-b)carbazole (FICZ) (172922-91-7) is a very potent (Kd?= 0.07 nM) endogenous ligand for the aryl hydrocarbon receptor (AhR).1,2
Uses
6-Formylindolo[3,2-b]carbazole is a tryptophan photoproduct, suppresses pulmonary eosinophilia and Th2-type cytokine production in a mouse model of ovalbumin-induced allergic asthma.
Biochem/physiol Actions
FICZ is a potent high affinity ligand of the aryl hydrocarbon receptor (AhR), which is a ligand-activated transcription factor that activates the expression of aromatic hydrocarbon metabolizing enzyme genes such as the CYP1A1 gene and has also been shown to have multiple additional roles in cell-cycle regulation, development and maturation of many tissues, control of inflammation, and immune response. FICZ is a photoproduct of tryptophan and is believed to be an endogenous AhR ligand. It is extremely potent, with a Kd value of 0.07 nM.
storage
Store at -20°C
References
1) Rannung?et al. (1987)?Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances; J. Biol. Chem.,?262?15422 .2) Wincent?et al. (2009)?The Suggested Physiologic Aryl Hydrocarbon Receptor Activator and Cytochrome P4501 Substrate 6-Formylindolo[3,2-b}carbazole is Present in Humans; J. Biol. Chem.,?284?2690
6-ForMylindolo[3,2-b]carbazole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21149 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Sichuan Biosynce Pharmatech Co., Ltd. | +8619950309693 | diane@biosynce.com | China | 4874 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |