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(1R,2S,3R)-Aprepitant

(1R,2S,3R)-Aprepitant structure

CAS No.: 1185502-97-9

Chemical Name:: (1R,2S,3R)-Aprepitant

Synonyms: (R,S,R)-Aprepitant;1R, 2S, 3R)-Aripitan;Aprepitant impurity 06;(2S,3R,1’R)-Aprepitant;Aprepitant (R,S,R)-Isomer;Aprepitant impurity 6/(1R,2S,3R)-Aprepitant;5-([(2S,3R)-2-((R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluoro phenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one;5-(((2S,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one;3H-1,2,4-Triazol-3-one, 5-[[(2S,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-;3-(((2S,3R)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one (Aprepitant impurity)

CBNumber:: CB53146508

Molecular Formula:: C23H21F7N4O3

Molecular Weight:: 534.43

MDL Number:: MFCD24386574

MOL File:: 1185502-97-9.mol

Last updated:2023-05-04 17:34:32

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(1R,2S,3R)-Aprepitant Properties

Density	1.51±0.1 g/cm3(Predicted)
pka	8.06±0.20(Predicted)

(1R,2S,3R)-Aprepitant price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	A729775	(2S,3R,1’R)-Aprepitant	1185502-97-9	1mg	$115	2021-12-16	Buy

Product number	Packaging	Price	Buy
A729775	1mg	$115	Buy

(1R,2S,3R)-Aprepitant Chemical Properties,Uses,Production

Uses

(2S,3R,1’R)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.

Definition

ChEBI: 5-[[(2S,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-1,2,4-triazol-3-one is a member of morpholines.

(1R,2S,3R)-Aprepitant Preparation Products And Raw materials

Raw materials

Preparation Products

(1R,2S,3R)-Aprepitant Suppliers

Global( 41)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
CR Corporation Lomited		fred.wen@crcorporation.cn	CHINA	12069	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19994	58
China National Standard Pharmaceutical Corporation Limited	+8615391658522	overseasales@yongstandards.com	China	11927	58
Adamas Reagent, Ltd.	400-6009262 16621234537	zhangsn@titansci.com	China	14113	59
S.Z. PhyStandard Bio-Tech. Co., Ltd.	0755-4000505016 13380397412	3001272453@qq.com	China	4967	50
ChemStrong Scientific Co.,Ltd	0755-0755-66853366 13670046396	sales@chem-strong.com	China	17993	56
Nanjing XiZe Biotechnology CO., Ltd.	025-58362220 15250997978	1511893459@qq.com	China	7725	55
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65

Supplier	Advantage
Standardpharm Co. Ltd.	58
BOC Sciences	58
CR Corporation Lomited	58
Labnetwork lnc.	58
China National Standard Pharmaceutical Corporation Limited	58
Adamas Reagent, Ltd.	59
S.Z. PhyStandard Bio-Tech. Co., Ltd.	50
ChemStrong Scientific Co.,Ltd	56
Nanjing XiZe Biotechnology CO., Ltd.	55
BOC Sciences	65

1185502-97-9((1R,2S,3R)-Aprepitant)Related Search:

Aprepitant-M3 Metabolite 1,1,1-Trimethoxy-2-chloroethane Aprepitant Impurity 19 Benzyl dihydrogen phosphate (2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine

Aprepitant Fosaprepitant dimeglumine 5-(hydroxymethyl)-1,2-dihydro-1,2,4-triazol-3-one Aprepitant Aprepitant

[2R-[2aR*),3a]-2-[1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine Aprepitant Aprepitant Defluoro Aprepitant Aprepitant Impurity B HCl

5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one Aprepitant Impurity 11 HCl Aprepitant Impurity 2

1of4

(R,S,R)-Aprepitant Aprepitant (R,S,R)-Isomer Aprepitant impurity 6/(1R,2S,3R)-Aprepitant 1R, 2S, 3R)-Aripitan 5-([(2S,3R)-2-((R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluoro phenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one 3H-1,2,4-Triazol-3-one, 5-[[(2S,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro- 5-(((2S,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (2S,3R,1’R)-Aprepitant Aprepitant impurity 06 3-(((2S,3R)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one (Aprepitant impurity) 1185502-97-9