Triethyl citrate
- CAS No.
- 77-93-0
- Chemical Name:
- Triethyl citrate
- Synonyms
- TEC;Citroflex 2;ETHYL CITRATE;citroflex2;Crodamol TC;Hydagen C.A.T;triethyl ester;triethyl 2-hydroxypropane-1,2,3-tricarboxylate;2-Hydroxy-1,2,3-propanetricarboxylic acid, triethyl ester;nsc8907
- CBNumber:
- CB5854363
- Molecular Formula:
- C12H20O7
- Molecular Weight:
- 276.28
- MDL Number:
- MFCD00009201
- MOL File:
- 77-93-0.mol
- MSDS File:
- SDS
| Melting point | -55 °C |
|---|---|
| Boiling point | 235 °C/150 mmHg (lit.) |
| Density | 1.14 g/mL at 25 °C (lit.) |
| vapor density | 9.7 (vs air) |
| vapor pressure | 1 mm Hg ( 107 °C) |
| refractive index |
n |
| FEMA | 3083 | TRIETHYL CITRATE |
| Flash point | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | H2O: soluble |
| pka | 11.57±0.29(Predicted) |
| form | Liquid |
| color | Clear |
| Odor | odorless |
| Water Solubility | 5.7 g/100 mL (25 ºC) |
| FreezingPoint | -55℃ |
| Merck | 14,2326 |
| JECFA Number | 629 |
| BRN | 1801199 |
| InChIKey | DOOTYTYQINUNNV-UHFFFAOYSA-N |
| LogP | 1.267 (est) |
| CAS DataBase Reference | 77-93-0(CAS DataBase Reference) |
| FDA 21 CFR | 184.1911; 175.300; 175.320; 181.27 |
| Substances Added to Food (formerly EAFUS) | TRIETHYL CITRATE |
| SCOGS (Select Committee on GRAS Substances) | Triethyl citrate |
| EWG's Food Scores | 1 |
| FDA UNII | 8Z96QXD6UM |
| NIST Chemistry Reference | Ethyl citrate(77-93-0) |
| EPA Substance Registry System | Triethyl citrate (77-93-0) |
Triethyl citrate price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W308307 | Triethyl citrate ≥99%, FCC, FG | 77-93-0 | 1kg | $110 | 2024-03-01 | Buy |
| Sigma-Aldrich | W308307 | Triethyl citrate ≥99%, FCC, FG | 77-93-0 | 10Kg | $525 | 2024-03-01 | Buy |
| Sigma-Aldrich | W308307 | Triethyl citrate ≥99%, FCC, FG | 77-93-0 | 25kg | $925 | 2024-03-01 | Buy |
| Sigma-Aldrich | W308302 | Triethyl citrate natural, ≥99%, FG | 77-93-0 | 1kg | $122 | 2024-03-01 | Buy |
| Sigma-Aldrich | W308302 | Triethyl citrate natural, ≥99%, FG | 77-93-0 | 5kg | $411 | 2024-03-01 | Buy |
Triethyl citrate Chemical Properties,Uses,Production
Toxicity
AD10~20mg/kg (FAO/WHO, 2001). GRAS (FDA, §182.1911, 2000). LD505900 mg/kg (rat, oral).
Description
Triethyl citrate is the triester of citric acid and ethyl alcohol.
Triethyl citrate is used as a flavoring agent in foods, as a high boiling solvent and plasticizer for vinyl resins and cellulose acetates, as a plasticizer in the pharmaceutical industry for coating. Triethyl citrate is used as a natural active ingredient and flavor component with excellent deodorizing and skin care properties in cosmetic and personal care products. Triethyl citrate is also used as a plasticizer and humectant for cigarette filters. Furthermore, triethyl citrate is used s a food additive for stabilizing foams, specifically as a whipping enhancer for organic egg whites during processing.
References
[1] RH Dave (2016) Overview of pharmaceutical excipients used in tablets and capsules, Drug Topics (online). Advanstar.
[2] http://www.who.int/en/
[3] http://www.in-cosmetics.com
[4] http://www.chemicalland21.com
[5] https://www.ams.usda.gov/sites/default/files/media/Triethyl%20Citrate%20report%202014.pdf
Chemical Properties
Triethyl citrate is a clear, viscous, odorless, and practically colorless, hygroscopic liquid.
Chemical Properties
Colorless, mobile liquid; bitter taste. Solubility in water 6.5 g/100 cc; solubility in oil 0.8 g/100 cc. Combustible.
Chemical Properties
Triethyl citrate is odorless, but has a bitter taste.
Occurrence
Reported found in Morello cherry, sour cherry and red currant. Also reported found in raw cabbage and white wine.
Uses
Triethyl Citrate, is a colorless, odorless liquid used as a food additive to stabilize foams, especially as whipping aid for egg white. It is also used in pharmaceutical coatings and plastics. This compound is a contaminant of emerging concern (CECs).
Uses
Pharmaceutic aid (plasticizer).
Uses
Triethyl Citrate is a sequestrant that is an oily liquid, slightly solu- ble in water. it is found in lemon drinks.
Production Methods
Triethyl citrate is prepared by the esterification of citric acid and ethanol in the presence of a catalyst.
Definition
ChEBI: Triethyl citrate is a carbonyl compound.
Preparation
By esterification of ethyl alcohol with citric acid.
General Description
Triethyl citrate is a safe direct food additive.
Pharmaceutical Applications
Triethyl citrate and the related esters acetyltriethyl citrate, tributyl
citrate, and acetyltributyl citrate are used to plasticize polymers in
formulated pharmaceutical coatings. The coating applications
include capsules, tablets, beads, and granules for taste masking,
immediate release, sustained-release, and enteric formulations.
Triethyl citrate is also used as a direct food additive for flavoring,
for solvency, and as a surface active agent.
Safety Profile
Moderately toxic by intraperitoneal route. Mildly toxic by ingestion and inhalation. Combustible liquid when exposed to heat or flame. To fight fire, use dry chemical, CO2. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS and CITRIC ACID.
Safety
Triethyl citrate is used in oral pharmaceutical formulations and as a
direct food additive. It is generally regarded as a nontoxic and
nonirritant material. However, ingestion of large quantities may be
harmful.
LD50 (mouse, IP): 1.75 g/kg
LD50 (rat, IP): 4 g/kg
LD50 (rat, oral): 5.9 g/kg
LD50 (rat, SC): 6.6 g/kg
storage
Triethyl citrate should be stored in a closed container in a cool, dry location. When stored in accordance with these conditions, triethyl citrate is a stable product.
Incompatibilities
Triethyl citrate is incompatible with strong alkalis and oxidizing materials.
Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in the Canadian List of Acceptable Nonmedicinal Ingredients.
Triethyl citrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangxi Alpha Hi-tech Pharmaceutical Co., Ltd | 510-85010237 | overseamarketing@alphahi-tech.com | CHINA | 41 | 58 |
| Weifang Wehibest Supply Chain Co.,Ltd | +8613583620690 | hotspotbiotech@163.com | China | 926 | 58 |
| Hebei Yime New Material Technology Co., Ltd. | +86-66697723 +86-17703311139 | admin@china-yime.com | China | 563 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Hebei Jingbo New Material Technology Co., Ltd | +8619931165850 | hbjbtech@163.com | China | 1000 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 16799 | 58 |
| Hebei Saisier Technology Co., LTD | +86-18400010335 +86-13102810335 | admin@hbsaisier.cn | China | 931 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | sarah@tnjone.com | China | 1072 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 1351 | 58 |
| Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 | clara@hbshengyang.com | China | 703 | 58 |
Related articles
- The synthesis of triethyl citrate
- Triethyl citrate is a plasticizer of adhesive and sealant, with molecular formula of c12h20o7. It has strong solubility and go....
- Jun 27，2022
View Lastest Price from Triethyl citrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-05-11 | Triethyl citrate
77-93-0
|
US $10.00 / kg | 1kg | 99% | 5000 | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2024-05-11 | Triethyl citrate
77-93-0
|
US $18.00-18.00 / kg | 1kg | 99.9 | 5000 | Hebei Shengyang Water Conservancy Engineering Co., Ltd. | |
 |
2024-05-11 | Triethyl citrate
77-93-0
|
US $0.00-0.00 / kg | 1kg | 99% | 500000kg | Hebei Kingfiner Technology Development Co.Ltd |
-
- Triethyl citrate
77-93-0
- US $10.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- Triethyl citrate
77-93-0
- US $18.00-18.00 / kg
- 99.9
- Hebei Shengyang Water Conservancy Engineering Co., Ltd.
-
- Triethyl citrate
77-93-0
- US $0.00-0.00 / kg
- 99%
- Hebei Kingfiner Technology Development Co.Ltd