Apoptolidin
- CAS No.
- 194874-06-1
- Chemical Name:
- Apoptolidin
- Synonyms
- FU 40A;Apoptolidin;Apoptolidin A Ready Made Solution;L-glycero-α-D-galacto-2-Nonulopyranose, O-2,6-dideoxy-3-O-methyl-β-D-arabino-hexopyranosyl-(1→4)-O-2,6-dideoxy-3-C-methyl-α-L-arabino-hexopyranosyl-(1→8)-3,5,7-trideoxy-1-C-[(2S,4S,5S,8E,10E,12R,13R,14E,16E,18E)-12-[(6-deoxy-4-O-methyl-α-L-glucopyranosyl)oxy]-5-hydroxy-4-methoxy-9,13,15,17,19-pentam...
- CBNumber:
- CB61093252
- Molecular Formula:
- C58H96O21
- Molecular Weight:
- 1129.38
- MDL Number:
- MFCD09752711
- MOL File:
- 194874-06-1.mol
- MSDS File:
- SDS
| Melting point | 128-130° |
|---|---|
| alpha | 21D -5.2° (c = 1.0 in methanol) |
| Boiling point | 1108.9±65.0 °C(Predicted) |
| Density | 1.25±0.1 g/cm3(Predicted) |
| Flash point | 87℃ |
| storage temp. | -20°C |
| solubility | Soluble in DMSO, DMF, ethanol, or methanol. |
| pka | 11.71±0.70(Predicted) |
| form | DMSO solution |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, ethanol or methanol may be stored at -20°C for up to 3 months. |
| FDA UNII | SAO6WVQ23I |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P330-P302+P352-P321-P305+P351+P338-P332+P313-P362+P364-P337+P313-P501 | |||||||||
| RIDADR | NA 1993 / PGIII | |||||||||
| WGK Germany | 2 | |||||||||
| NFPA 704 |
|
Apoptolidin price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0907 | Apoptolidin A Ready Made Solution 1?mg/mL in DMSO | 194874-06-1 | 500μl | $971 | 2024-03-01 | Buy |
| Cayman Chemical | 19435 | Apoptolidin ≥95% | 194874-06-1 | 100μg | $263 | 2024-03-01 | Buy |
| Cayman Chemical | 19435 | Apoptolidin ≥95% | 194874-06-1 | 500μg | $1043 | 2024-03-01 | Buy |
| TRC | A729048 | Apoptolidin | 194874-06-1 | 250μg | $430 | 2021-12-16 | Buy |
| TRC | A729048 | Apoptolidin | 194874-06-1 | 100μg | $215 | 2021-12-16 | Buy |
Apoptolidin Chemical Properties,Uses,Production
Description
Apoptolidin (194874-06-1) is a powerful inducer of apoptosis in a variety of cancer cell lines.1?Is believed to act via inhibition of F0F1-ATPase2?but correlation studies indicate that a second mechanism may be the actual mode of action3.? Cell permeable.
Uses
Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene (IC50 = 11 ng/ml). Apoptolidin is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines. Although the apoptotic activity of apoptolidin correlates with F0F1-ATPase inhibition, recent evidence suggests the existence of a secondary biological target or more complex mode of action.
References
1) Kim et al. (1997), Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp.; J. Antibiot. (Tokyo), 50 628 2) Salomon et al. (2001), Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase; Chem. Biol., 8 71 3) Wender et al. (2006), Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues; Org. Lett., 8 589
Apoptolidin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55954 | 58 |
| Meng Cheng Technology (Shanghai) Co., LTD | 400-820-6829 | sales@mitachieve.com | China | 8864 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903882 13626641628 | jiangnan@huidabiotech.com | China | 3656 | 58 |