ChemicalBook >> CAS DataBase List >>3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE
3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE
- CAS No.
- 335165-68-9
- Chemical Name:
- 3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE
- Synonyms
- BAX CHANNEL BLOCKER;Bax channel blocke;)-3-(piperazin-1-yL;Baxchannelblocker2HCl;1-(3,6-Dibromo-9H-carbazoL;Bax channel blocker(BAI-1);BAI1 (Bax channel blocker);9H-Carbazole-9-ethanol, 3,6-dibromo-α-(1-piperazinylmethyl)-;1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol;"(+/-)-1-(3,6-dibromocarbazol-9-yl)-3-piperazin-1-ylpropan-2-ol"
- CBNumber:
- CB6143286
- Molecular Formula:
- C19H21Br2N3O
- Molecular Weight:
- 467.2
- MDL Number:
- MFCD00276492
- MOL File:
- 335165-68-9.mol
Last updated:2023-05-18 11:31:05
| Boiling point | 388.1±42.0 °C(Predicted) |
|---|---|
| Density | 1.71±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | ≥28.2 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O |
| form | solid |
| pka | 14.48±0.20(Predicted) |
| color | White |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J64257 | Bax Channel Blocker | 335165-69-0 | 10mg | $151 | 2021-12-16 | Buy |
| Tocris | 2160 | Bax Channel Blocker ≥98%(HPLC) | 335165-68-9 | 10 | $195 | 2021-12-16 | Buy |
| Tocris | 2160 | Bax Channel Blocker ≥98%(HPLC) | 335165-68-9 | 50 | $818 | 2021-12-16 | Buy |
| Usbiological | 254714 | Bax channel blocker | 335165-68-9 | 10mg | $446 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001067 | BAX CHANNEL BLOCKER 95.00% | 335165-68-9 | 5MG | $498.81 | 2021-12-16 | Buy |
3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE Chemical Properties,Uses,Production
Uses
Bax channel blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome c release.
Biological Activity
Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC 50 = 0.52 μ M). Suggested to inhibit Bax channel formation/activity.
in vitro
bax channel blocker, a 3,6-dibromocarbazole derivative, was observed to inhibit cytochrome c releasing from mitochondria by bax channel modulation. the monohydroxy analogue bax channel blocker remained the unprecedented inhibition of bax-induced cytochrome c release at 10 μm. the ic50 value of bax channel blocker was determined to be 0.52 μm, indicating that bax channel blocker was a bax channel inhibitor as hypothesized. moreover, in the liposome assay, bax channel blocker showing significant inhibition (>65%) of cytochrome c release at 10 μm also demonstrated sub-micromolar ic50 value [1].
IC 50
0.52 μm in bax assay
References
[1] bombrun a,gerber p,casi g,terradillos o,antonsson b,halazy s. 3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via bax channel modulation. j med chem.2003 oct 9;46(21):4365-8.
Synthesis of 3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-
3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE Preparation Products And Raw materials
3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE Suppliers
Global( 73)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Sichuan Biosynce Pharmatech Co., Ltd. | +8619950309693 | diane@biosynce.com | China | 4874 | 58 |
335165-68-9(3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE)Related Search:
Carbazole-9-ethanol
3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE
5-Bromo-1-methyl-1H-indole
1-(4-[2-HYDROXY-3-(1,3,6-TRIBROMO-9H-CARBAZOL-9-YL)PROPYL]PIPERAZINO)-3-(1,3,6-TRIBROMO-9H-CARBAZOL-9-YL)PROPAN-2-OL DIHYDROCHLORIDE
3,6-Dibromo-9-ethylcarbazole
1of3
Baxchannelblocker2HCl
3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE
3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanoldihydrochloride
Bax channel blocke
Bax channel blocker(BAI-1)
1-(3,6-Dibromo-9H-carbazoL
9H-Carbazole-9-ethanol, 3,6-dibromo-α-(1-piperazinylmethyl)-
)-3-(piperazin-1-yL
1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol
BAI1 (Bax channel blocker)
"(+/-)-1-(3,6-dibromocarbazol-9-yl)-3-piperazin-1-ylpropan-2-ol"
BAX CHANNEL BLOCKER
Inhibitor,mitochondrial,cell,inhibit,BAI1,effector,BAI 1,critical,BAX,death,BAI-1,Bcl-2 Family,pathway,Apoptosis
335165-68-9
335165-69-9
C19H21Br2N3O2HCl
Caspases/Apoptosis
Apoptosis Inhibitors